公开(公告)号：US09040559B2

公开(公告)日：2015-05-26

申请号：US14450692

申请日：2014-08-04

Applicant: Novartis AG

Inventor： Bernard Cuenoud ,  Ian Bruce ,  Robin Alec Fairhurst ,  David Beattie

IPC: A61K31/395 ,  A61K31/4709 ,  C07C215/80 ,  C07C233/43 ,  C07C311/08 ,  C07D215/227 ,  C07D215/26 ,  C07D405/12 ,  A61K45/06

CPC classification number: A61K31/4709 ,  A61K45/06 ,  C07C215/80 ,  C07C233/43 ,  C07C311/08 ,  C07C2602/08 ,  C07D215/227 ,  C07D215/26 ,  C07D405/12

Abstract: Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.

Abstract translation: 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。

公开(公告)号：US10183025B2

公开(公告)日：2019-01-22

申请号：US15673155

申请日：2017-08-09

Applicant: Novartis AG

Inventor： David Beattie ,  Urs Baettig ,  Darren Mark Le Grand ,  Andrew Stuart Lister ,  Jeffrey McKenna ,  David William Pearce ,  David Andrew Sandham ,  Oliver Ross Steward ,  Christopher Thomson

IPC: A61K31/445 ,  A61K31/551 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/5377 ,  A61K31/5513 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D403/14 ,  C07D407/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/14 ,  C07D257/04 ,  A61K45/06 ,  A61K31/45 ,  A61K31/496 ,  A61K31/504 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D405/12 ,  C07D471/08

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

公开(公告)号：US09763957B2

公开(公告)日：2017-09-19

申请号：US14906161

申请日：2014-07-16

Applicant: Novartis AG

Inventor： David Beattie ,  Urs Baettig ,  Darren Mark Legrand ,  Andrew Stuart Lister ,  Jeffrey McKenna ,  David William Pearce ,  David Andrew Sandham ,  Oliver Ross Steward ,  Christopher Thomson

IPC: A61K31/445 ,  A61K31/551 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/5377 ,  A61K31/5513 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D403/14 ,  C07D407/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/14 ,  C07D257/04 ,  A61K45/06 ,  A61K31/45 ,  A61K31/496 ,  A61K31/504 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D405/12 ,  C07D471/08

CPC classification number: A61K31/551 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/445 ,  A61K31/45 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/504 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D257/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/08 ,  A61K2300/00

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.