公开(公告)号：US12214037B2

公开(公告)日：2025-02-04

申请号：US17359211

申请日：2021-06-25

Applicant: The Trustees of the University of Pennsylvania ,  Novartis AG

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Jonathan Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: A61K39/00 ,  A61K39/395 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  A61K35/12 ,  A61K38/17 ,  A61P35/00 ,  C07H21/04 ,  C07K14/715 ,  C07K19/00 ,  C12N5/00 ,  C12N15/63

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US11084880B2

公开(公告)日：2021-08-10

申请号：US16197565

申请日：2018-11-21

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Jonathan Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: C07K16/28 ,  C07K14/705 ,  C07K19/00 ,  C07K14/725 ,  A61P35/00 ,  A61K39/395 ,  A61K35/12 ,  A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US20210002377A1

公开(公告)日：2021-01-07

申请号：US16884867

申请日：2020-05-27

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Saar Gill ,  David Jonathan Glass ,  Saad Kenderian ,  Andreas Loew ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  David L. Porter ,  Marco Ruella ,  Yongqiang Wang ,  Qilong Wu ,  Jiquan Zhang

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/24 ,  C12N5/0783

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.

公开(公告)号：US10435460B2

公开(公告)日：2019-10-08

申请号：US15829115

申请日：2017-12-01

Applicant: Novartis AG

Inventor： Johanna Abend ,  Zorica Dragic ,  Adam Lloyd Feire ,  Mark Knapp ,  Steven Kovacs ,  Elisabetta Traggiai ,  Lichun Wang ,  Yongqiang Wang ,  Danqing Wu ,  Qilong Wu ,  Fangmin Xu

IPC: A61K39/12 ,  A61K39/42 ,  C07K16/08 ,  A61K45/06 ,  A61K9/19

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20180312595A1

公开(公告)日：2018-11-01

申请号：US15726703

申请日：2017-10-06

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Saar Gill ,  David Jonathan Glass ,  Saad Kenderian ,  Andreas Loew ,  Joan Mannick ,  Michael Milone ,  Leon Murphy ,  David L. Porter ,  Marco Ruella ,  Yongqiang Wang ,  Qilong Wu ,  Jiquan Zhang

IPC: C07K16/28 ,  A61K39/00 ,  C12N5/0783 ,  C07K16/24

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.

公开(公告)号：US20230220090A1

公开(公告)日：2023-07-13

申请号：US18148807

申请日：2022-12-30

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Saar Gill ,  David Glass ,  Saad Kenderian ,  Andreas Loew ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  David L. Porter ,  Marco Ruella ,  Yongqiang Wang ,  Qilong Wu ,  Jiquan Zhang

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/24 ,  C12N5/0783

CPC classification number: C07K16/2866 ,  A61K39/001119 ,  C07K16/244 ,  C12N5/0636 ,  C07K2317/622 ,  C07K2319/33 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K2317/76 ,  C07K2317/73 ,  C07K2319/03 ,  A61K2039/507 ,  C07K2317/24

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.

公开(公告)号：US20230052970A1

公开(公告)日：2023-02-16

申请号：US17937488

申请日：2022-10-03

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Hilmar Erhard Ebersbach ,  David Glass ,  Thomas Huber ,  Julia Jascur ,  Carl H. June ,  Jihyun Lee ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Avery D. Posey ,  Huijuan Song ,  Yongqiang Wang ,  Lai Wei ,  Qilong Wu ,  Qiumei Yang ,  Jiquan Zhang

IPC: C07K16/28 ,  A61K35/17 ,  C07K16/30 ,  C07K14/705 ,  A61P35/02 ,  A61P35/00 ,  A61K48/00 ,  C07K14/725 ,  C12N15/86

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

公开(公告)号：US20220064316A1

公开(公告)日：2022-03-03

申请号：US17359211

申请日：2021-06-25

Applicant: The Trustees of the University of Pennsylvania ,  Novartis AG

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Jonathan Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: C07K16/28 ,  C07K14/725 ,  C07K19/00 ,  A61P35/00 ,  C07H21/04 ,  C07K14/715 ,  A61K39/395 ,  A61K38/17 ,  C12N5/00 ,  C12N15/63 ,  C07K14/705 ,  A61K35/12

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US12077571B2

公开(公告)日：2024-09-03

申请号：US18186064

申请日：2023-03-17

Applicant: Novartis AG

Inventor： Johanna Abend ,  Zorica Dragic ,  Adam Lloyd Feire ,  Mark Knapp ,  Steven Kovacs ,  Elisabetta Traggiai ,  Lichun Wang ,  Yongqiang Wang ,  Danqing Wu ,  Qilong Wu ,  Fangmin Xu

IPC: A61K45/06 ,  A61K9/19 ,  A61K39/42 ,  C07K16/08

CPC classification number: C07K16/084 ,  A61K9/19 ,  A61K39/42 ,  A61K45/06 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US11591404B2

公开(公告)日：2023-02-28

申请号：US16884867

申请日：2020-05-27

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Saar Gill ,  David Jonathan Glass ,  Saad Kenderian ,  Andreas Loew ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  David L. Porter ,  Marco Ruella ,  Yongqiang Wang ,  Qilong Wu ,  Jiquan Zhang

IPC: C07K16/28 ,  C07K16/24 ,  C12N5/0783 ,  A61K39/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.