公开(公告)号：US20180296837A1

公开(公告)日：2018-10-18

申请号：US16014822

申请日：2018-06-21

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Shu XIAO ,  Andrei PAKHOMOV ,  Karl H. SCHOENBACH

IPC: A61N1/36 ,  A61N5/02 ,  A61N2/00 ,  A61N1/40

CPC classification number: A61N1/36014 ,  A61N1/40 ,  A61N2/006 ,  A61N5/02

Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.

公开(公告)号：US20170319843A1

公开(公告)日：2017-11-09

申请号：US15654625

申请日：2017-07-19

Applicant: Eastern Virginia Medical School ,  Old Dominion University Research Foundation

Inventor： Stephen J. BEEBE ,  Karl H. SCHOENBACH

IPC: A61N1/04 ,  C12M1/42 ,  A61N1/32 ,  C12N15/87 ,  C12N13/00 ,  A61K48/00

CPC classification number: A61N1/0412 ,  A61K48/00 ,  A61N1/327 ,  C12M35/02 ,  C12N13/00 ,  C12N15/87

Abstract: A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.

公开(公告)号：US20180200510A1

公开(公告)日：2018-07-19

申请号：US15922758

申请日：2018-03-15

Applicant: Eastern Virginia Medical School ,  Old Dominion University Research Foundation

Inventor： Richard NUCCITELLI ,  Stephen J. BEEBE ,  Karl H. SCHOENBACH

IPC: A61N1/20 ,  A61N1/32

CPC classification number: A61N1/205 ,  A61N1/327

Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.

公开(公告)号：US20190038337A1

公开(公告)日：2019-02-07

申请号：US16057115

申请日：2018-08-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. SCHOENBACH ,  Richard HELLER ,  James CAMP ,  Stephen P. BEEBE ,  Shu XIAO ,  Amy DONATE

IPC: A61B18/12 ,  A61N5/06 ,  A61N1/32 ,  A61N1/40 ,  A61N5/00 ,  A61N5/02 ,  A61B18/00 ,  A61B18/24 ,  A61B18/20 ,  A61B18/18 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

公开(公告)号：US20160015971A1

公开(公告)日：2016-01-21

申请号：US14869286

申请日：2015-09-29

Applicant: Eastern Virginia Medical School ,  Old Dominion University Research Foundation

Inventor： Richard NUCCITELLI ,  Stephen J. BEEBE ,  Karl H. SCHOENBACH

IPC: A61N1/20

CPC classification number: A61N1/205 ,  A61N1/327

Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.

Abstract translation: 提供了通过施加纳秒脉冲电场（“nsPEF”）治疗实体皮肤肿瘤的新的无药物治疗方法。 在本发明的一个实施方案中，细胞是黑素瘤细胞，并且所应用的nsPEFs渗透到肿瘤细胞的内部并使肿瘤细胞核迅速收缩并且肿瘤血流停止。 这种新技术提供了高度定位的肿瘤细胞靶向，对上覆皮肤仅起微量的作用。