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公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译： 本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。 系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。 序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。 与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。
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2.发明授权
公开(公告)号：US5858708A
公开(公告)日：1999-01-12
申请号：US700607
申请日：1996-08-12
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/28 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/28 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/08 , C12N15/85
CPC分类号： C07K16/18 , C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides polynucleotides which identify and encode two novel human NSP-like proteins (NSPLP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NSPLP. The invention also provides for the use of substantially purified NSPLP, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of NSPLP. Additionally, the invention provides for the use of antisense molecules to NSPLP in pharmaceutical compositions for treatment of diseases associated with the expression of NSPLP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NSPLP or anti-NSPLP antibodies which specifically bind to NSPLP.
摘要翻译： 本发明提供鉴定和编码两种新型人NSP样蛋白（NSPLP）的多核苷酸。 本发明提供了包含编码NSPLP的核酸序列的基因工程表达载体和宿主细胞。 本发明还提供使用基本纯化的NSPLP，拮抗剂和药物组合物来治疗与NSPLP表达相关的疾病。 此外，本发明提供了用于治疗与NSPLP表达相关的疾病的药物组合物中NSPLP的反义分子的用途。 本发明还描述了使用包含多核苷酸，其片段或其互补体的诊断组合物的诊断测定法，其与编码特异性结合NSPLP的NSPLP或抗NSPLP抗体的多核苷酸的基因组序列或转录物杂交。
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公开(公告)号：US5843715A
公开(公告)日：1998-12-01
申请号：US701935
申请日：1996-08-23
CPC分类号： C12N9/6421 , C12Y304/25001 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode novel human proteasome subunit proteins. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PSUB. The invention also provides for the use of substantially purified PSUB, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of PSUB. Additionally, the invention provides for the use of antisense molecules to PSUB in pharmaceutical compositions for treatment of diseases associated with the expression of PSUB. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding PSUB or anti-PSUB antibodies which specifically bind to PSUB.
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公开(公告)号：US5874286A
公开(公告)日：1999-02-23
申请号：US715204
申请日：1996-09-17
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/85
摘要： The present invention provides novel human tumor proteins (collectively called TUPRO) and polynucleotides which identify and encode TUPRO. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TUPRO. The invention also provides pharmaceutical compositions containing TUPRO or antagonists to TUPRO, and in the use of these compositions for the treatment of diseases associated with the expression of TUPRO. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TUPRO for the treatment of diseases associated with the expression of TUPRO. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding TUPRO or anti-TUPRO antibodies which specifically bind to TUPRO.
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公开(公告)号：US5843714A
公开(公告)日：1998-12-01
申请号：US695736
申请日：1996-07-26
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12N15/11 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides polynucleotides which identify and encode a novel human proteolipid (PLHu). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PLHu. The invention also provides for the use of substantially purified PLHu and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of PLHu. Additionally, the invention provides for the use of antisense molecules to PLHu in the treatment of diseases associated with the expression of PLHu. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding PLHu and antibodies which specifically bind to the protein.
摘要翻译： 本发明提供鉴定和编码新的人类蛋白脂质（PLHu）的多核苷酸。 本发明提供了包含编码PLHu的核酸序列的基因工程表达载体和宿主细胞。 本发明还提供了在商业生产重组蛋白质中用于治疗与PLHu表达相关的疾病的基本上纯化的PLHu及其激动剂的用途。 另外，本发明提供了用于PLHu的反义分子用于治疗与PLHu表达相关的疾病的用途。 本发明还描述了利用包含与编码PLHu的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。
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公开(公告)号：US6043343A
公开(公告)日：2000-03-28
申请号：US162597
申请日：1998-09-29
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C07K14/47 , A61K38/17 , C07K16/30 , G01N33/53
摘要： The present invention provides novel human tumor proteins (collectively called TUPRO) and polynucleotides which identify and encode TUPRO. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TUPRO. The invention also provides pharmaceutical compositions containing TUPRO or antagonists to TUPRO, and in the use of these compositions for the treatment of diseases associated with the expression of TUPRO. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TUPRO for the treatment of diseases associated with the expression of TUPRO. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding TUPRO or anti-TUPRO antibodies which specifically bind to TUPRO.
摘要翻译： 本发明提供新型人肿瘤蛋白（统称为TUPRO）和识别和编码TUPRO的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码TUPRO的核酸序列的宿主细胞。 本发明还提供含有TUPRO或TUPRO拮抗剂的药物组合物，以及这些组合物用于治疗与TUPRO表达相关的疾病的药物组合物。 另外，本发明提供了将反义分子用于编码TUPRO的多核苷酸用于治疗与TUPRO表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其互补序列与编码特异性结合TUPRO的TUPRO或抗TUPRO抗体的多核苷酸的基因组序列或转录物进行杂交的诊断测定。
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公开(公告)号：US6018028A
公开(公告)日：2000-01-25
申请号：US134591
申请日：1998-08-13
CPC分类号： C12N9/6421 , C12Y304/25001 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode novel human proteasome subunit proteins. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PSUB. The invention also provides for the use of substantially purified PSUB, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of PSUB. Additionally, the invention provides for the use of antisense molecules to PSUB in pharmaceutical compositions for treatment of diseases associated with the expression of PSUB. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding PSUB or anti-PSUB antibodies which specifically bind to PSUB.
摘要翻译： 本发明提供鉴定和编码新的人蛋白酶体亚基蛋白的多核苷酸。 本发明提供了包含编码PSUB的核酸序列的基因工程表达载体和宿主细胞。 本发明还提供使用基本上纯化的PSUB，拮抗剂和药物组合物来治疗与PSUB表达相关的疾病。 另外，本发明提供了用于治疗与PSUB表达相关的疾病的药物组合物中PSUB的反义分子的用途。 本发明还描述了使用包含多核苷酸，其片段或其互补体的诊断组合物的诊断测定法，其与编码与PSUB特异性结合的PSUB或抗PSUB抗体的多核苷酸的基因组序列或转录物杂交。
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公开(公告)号：US5861495A
公开(公告)日：1999-01-19
申请号：US786606
申请日：1997-01-21
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides three zinc binding proteins (designated individually as ZB-1, ZB-2, and ZB-3, and collectively as ZB) and polynucleotides which identify and encode ZB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding ZB and a method for producing ZB. The invention also provides for use of ZB and agonists, antibodies, or antagonists specifically binding ZB, in the prevention and treatment of diseases associated with expression of ZB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding ZB for the treatment of diseases associated with the expression of ZB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding ZB.
摘要翻译： 本发明提供三种锌结合蛋白（分别命名为ZB-1，ZB-2和ZB-3，统称为ZB）和识别和编码ZB的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码ZB的核酸序列和生产ZB的方法。 本发明还提供使用ZB和特异性结合ZB的激动剂，抗体或拮抗剂在预防和治疗与ZB表达相关的疾病中的用途。 另外，本发明提供反义分子用于编码ZB的多核苷酸用于治疗与ZB表达有关的疾病。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合ZB的抗体的诊断测定法。
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公开(公告)号：US5792648A
公开(公告)日：1998-08-11
申请号：US690095
申请日：1996-07-31
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C07H21/04 , C12N15/63
CPC分类号： C07K14/7056 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human macrophage antigen (TMAH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding TMAH. The invention also provides for the use of substantially purified TMAH and its agonists, antibodies, antagonists or inhibitors in pharmaceutical compositions for treatment of diseases associated with expression of TMAH. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the genomic sequence or transcripts encoding TMAH and anti-TMAH antibodies which specifically bind to TMAH.
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公开(公告)号：US5734038A
公开(公告)日：1998-03-31
申请号：US700626
申请日：1996-08-16
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K45/08 , A61K48/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/00 , C07H21/04 , C12N1/20 , C12P21/06
摘要： The present invention provides polynucleotides which identify and encode a novel human Diazepam binding inhibitor/acyl-CoA binding protein (DBI/ACBP)-like protein (DBIH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding DBIH. The invention also provides for the use of substantially purified DBIH for drug delivery as well as for the production of recombinant proteins for the treatment of diseases associated with the expression of DBIH. Additionally, the invention provides for the use of antisense molecules to DBIH in the treatment of diseases associated with the expression of DBIH. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding DBIH and antibodies which specifically bind to the protein.
摘要翻译： 本发明提供鉴定并编码新的人地西泮结合抑制剂/酰基辅酶A结合蛋白（DBI / ACBP）样蛋白（DBIH）的多核苷酸。 本发明提供了包含编码DBIH的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供使用基本上纯化的DBIH用于药物递送以及用于产生用于治疗与DBIH表达相关的疾病的重组蛋白质。 另外，本发明提供了用于治疗与DBIH表达有关的疾病的DBIH反义分子的用途。 本发明还描述了利用包含与编码DBIH的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。
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