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    Lead fixation means
    3.
    发明授权
    Lead fixation means 有权
    铅固定方式

    公开(公告)号：US08019437B2

    公开(公告)日：2011-09-13

    申请号：US10772989

    申请日：2004-02-05

    申请人： Paul A. Iaizzo ,  Timothy G. Laske

    发明人： Paul A. Iaizzo ,  Timothy G. Laske

    IPC分类号： A61N1/04

    CPC分类号： A61N1/057 ,  A61B5/042 ,  A61B5/6882 ,  A61B2018/00273

    摘要： A medical electrical lead includes a glue segment to adhere the lead to a treatment site. The glue segment, which may be disposed within a tip electrode of the lead, includes tissue adhesive which may encapsulated within a capsule.

    摘要翻译： 医用电引线包括将引线粘附到治疗部位的胶粘部分。 可以设置在引线的尖端电极内的胶合部分包括可以封装在胶囊内的组织粘合剂。

    Isolated perfused heart preparation and method of use
    4.
    发明授权
    Isolated perfused heart preparation and method of use 有权
    分离灌注心脏准备及使用方法

    公开(公告)号：US07045279B1

    公开(公告)日：2006-05-16

    申请号：US09419271

    申请日：1999-10-15

    申请人： Timothy G. Laske ,  Paul A. Iaizzo ,  Mark A. Hjelle ,  Josée Morissette ,  Dale A. Wahlstrom

    发明人： Timothy G. Laske ,  Paul A. Iaizzo ,  Mark A. Hjelle ,  Josée Morissette ,  Dale A. Wahlstrom

    IPC分类号： C12N5/00

    CPC分类号： A01N1/02 ,  A01N1/0247 ,  Y10T436/108331

    摘要： An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, cardiac implants and other medical devices intended to be used in or on a beating heart. The preparation may also be employed to investigate heart functions, in the presence or absence of such medical devices. In order to allow for visualization of heart structures and devices located within the chambers of the heart, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and the coronary vasculature. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the heart.

    摘要翻译： 一种分离的心脏制剂，其中保留了心脏所有四个腔室的基本上正常的泵送活性，允许使用该制剂与电极引线，导管，心脏植入物和旨在用于或在其上使用的其它医疗装置 一个跳动的心脏 在存在或不存在这样的医疗装置的情况下，该制剂也可用于研究心脏功能。 为了允许位于心脏腔室内的心脏结构和装置的可视化，清洁的灌注液（例如具有氧合作用的改良的克雷伯斯缓冲溶液）通过心脏和冠状动脉脉管系统的所有四个腔室循环。 制剂的准备和记录可以与在心脏或心脏上使用的装置的设计，开发和评估结合使用，以及用作调查和教学辅助以帮助医师和学生理解操作 心脏

    Percutaneous atrial and ventricular septal defect closure device
    5.
    发明授权
    Percutaneous atrial and ventricular septal defect closure device 有权
    经皮心房和室间隔缺损闭合装置

    公开(公告)号：US09445797B2

    公开(公告)日：2016-09-20

    申请号：US13614592

    申请日：2012-09-13

    申请人： Paul Rothstein ,  Paul A. Iaizzo

    发明人： Paul Rothstein ,  Paul A. Iaizzo

    IPC分类号： A61B17/08 ,  A61B17/00

    CPC分类号： A61B17/0057 ,  A61B2017/00575 ,  A61B2017/00584 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00623 ,  A61B2017/00867

    摘要： Medical devices for closing anatomical apertures, such as atrial or ventricular septal defects, are disclosed. The medical devices can include a plug body having a proximal end, a distal end, and a longitudinal axis. The plug body can include an exterior surface, an interior surface defining an interior lumen, and a seal which can be located within the interior lumen. The medical devices can also include at least one arm member extending through the plug body between the exterior surface and the interior surface of the plug body. In certain embodiments, the medical device can include a distal loop and a proximal loop extending through the plug body. In certain embodiments, the proximal loop can be smaller than the distal loop, such that a top end and a bottom end of the proximal loop can fit within a top end and a bottom end of the distal loop.

    摘要翻译： 公开了用于闭合解剖孔的医疗装置，例如心房或室间隔缺损。 医疗装置可以包括具有近端，远端和纵向轴线的塞体。 塞体可以包括外表面，限定内腔的内表面和可位于内腔内的密封件。 医疗装置还可以包括至少一个臂构件，其延伸穿过插塞主体在外表面和插塞本体的内表面之间。 在某些实施例中，医疗装置可以包括远端环和延伸穿过插塞本体的近端环。 在某些实施例中，近端环可以小于远端环，使得近端环的顶端和底端可以配合在远端环的顶端和底端内。

    Percutaneous Atrial and Ventricular Septal Defect Closure Device
    7.
    发明申请
    Percutaneous Atrial and Ventricular Septal Defect Closure Device 有权
    经皮心房和室间隔缺损闭合装置

    公开(公告)号：US20140074155A1

    公开(公告)日：2014-03-13

    申请号：US13614592

    申请日：2012-09-13

    申请人： Paul Rothstein ,  Paul A. Iaizzo

    发明人： Paul Rothstein ,  Paul A. Iaizzo

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B2017/00575 ,  A61B2017/00584 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00623 ,  A61B2017/00867

    摘要： Medical devices for closing anatomical apertures, such as atrial or ventricular septal defects, are disclosed. The medical devices can include a plug body having a proximal end, a distal end, and a longitudinal axis. The plug body can include an exterior surface, an interior surface defining an interior lumen, and a seal which can be located within the interior lumen. The medical devices can also include at least one arm member extending through the plug body between the exterior surface and the interior surface of the plug body. In certain embodiments, the medical device can include a distal loop and a proximal loop extending through the plug body. In certain embodiments, the proximal loop can be smaller than the distal loop, such that a top end and a bottom end of the proximal loop can fit within a top end and a bottom end of the distal loop.

    摘要翻译： 公开了用于闭合解剖孔的医疗装置，例如心房或室间隔缺损。 医疗装置可以包括具有近端，远端和纵向轴线的塞体。 塞体可以包括外表面，限定内腔的内表面和可位于内腔内的密封件。 医疗装置还可以包括至少一个臂构件，其延伸穿过插塞主体在外表面和插塞本体的内表面之间。 在某些实施例中，医疗装置可以包括远端环和延伸穿过插塞本体的近端环。 在某些实施例中，近端环可以小于远端环，使得近端环的顶端和底端可以配合在远端环的顶端和底端内。

    System and method for determining tissue contact of an implantable medical device within a body
    8.
    发明授权
    System and method for determining tissue contact of an implantable medical device within a body 有权
    用于确定体内可植入医疗装置的组织接触的系统和方法

    公开(公告)号：US06714806B2

    公开(公告)日：2004-03-30

    申请号：US09952869

    申请日：2001-09-14

    申请人： Paul A. Iaizzo ,  Timothy G. Laske ,  Woohyek Choi

    发明人： Paul A. Iaizzo ,  Timothy G. Laske ,  Woohyek Choi

    IPC分类号： A61B504

    CPC分类号： A61B5/053 ,  A61B5/05 ,  A61N1/056 ,  A61N1/0573

    摘要： An improved system for monitoring the status of an IMD such as a medical electrical lead during an implant procedure is provided. The system includes a signal generator for supplying a first signal such as a constant current or voltage to the IMD. A resulting voltage or current signal is generated, respectively, and may be sensed as an indication of the impedance of a portion of the body that is proximal to one or more electrodes carried by the lead. This impedance indication is converted to an audible signal having a frequency that is proportional to the amplitude of the impedance indication. The pitch of the audible signal therefore rises when measured impedance increases, and drops as the impedance decreases. These pitch changes allow a user to determine positional information associated with the IMD, including the degree of lead tissue contact and extent of fixation of a device to tissue.

    摘要翻译： 提供了一种改进的系统，用于在植入过程期间监视诸如医疗电线之类的IMD的状态。 该系统包括用于向IMD提供诸如恒定电流或电压的第一信号的信号发生器。 分别产生所得到的电压或电流信号，并且可以将其感测为身体接近于由引线承载的一个或多个电极的部分的阻抗的指示。 该阻抗指示被转换成具有与阻抗指示的幅度成比例的频率的可听信号。 因此，当测量的阻抗增加时，听觉信号的音调会上升，并随着阻抗的降低而下降。 这些间距变化允许用户确定与IMD相关联的位置信息，包括铅组织接触的程度和装置固定到组织的程度。

    Pacing method
    9.
    发明授权
    Pacing method 有权
    起搏方式

    公开(公告)号：US08332035B2

    公开(公告)日：2012-12-11

    申请号：US12435987

    申请日：2009-05-05

    申请人： Paul A. Iaizzo ,  Timothy G. Laske

    发明人： Paul A. Iaizzo ,  Timothy G. Laske

    IPC分类号： A61N1/362

    CPC分类号： A61N1/056 ,  A61N1/0573

    摘要： A method for delivering physiological pacing includes selecting an electrode implant site for sensing cardiac signals, which is in proximity to the heart's intrinsic conduction system, where pacing stimulation results in a rhythm breaking out at an intrinsic location, and selected in response to a ratio of sensed P-wave amplitude to sensed R-wave amplitude.

    摘要翻译： 用于递送生理起搏的方法包括选择用于感测心脏信号的电极植入部位，该心脏信号位于心脏的本征传导系统附近，其中起搏刺激导致在内在位置处的节律破裂，并且响应于 感测到的P波幅度到感测到的R波幅度。

    PACING METHOD
    10.
    发明申请
    PACING METHOD 有权
    PACING方法

    公开(公告)号：US20090276000A1

    公开(公告)日：2009-11-05

    申请号：US12435987

    申请日：2009-05-05

    申请人： Paul A. Iaizzo ,  Timothy G. Laske

    发明人： Paul A. Iaizzo ,  Timothy G. Laske

    IPC分类号： A61N1/362

    CPC分类号： A61N1/056 ,  A61N1/0573

    摘要： A method for delivering physiological pacing includes selecting an electrode implant site for sensing cardiac signals, which is in proximity to the heart's intrinsic conduction system, where pacing stimulation results in a rhythm breaking out at an intrinsic location, and selected in response to a ratio of sensed P-wave amplitude to sensed R-wave amplitude.

    摘要翻译： 用于递送生理起搏的方法包括选择用于感测心脏信号的电极植入部位，该心脏信号位于心脏的本征传导系统附近，其中起搏刺激导致在内在位置处的节律破裂，并且响应于 感测到的P波幅度到感测到的R波幅度。