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公开(公告)号：US20150307551A1
公开(公告)日：2015-10-29
申请号：US14793942
申请日：2015-07-08
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
IPC: C07K7/06
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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公开(公告)号：US20140363452A1
公开(公告)日：2014-12-11
申请号：US14322262
申请日：2014-07-02
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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公开(公告)号：US20160271270A1
公开(公告)日：2016-09-22
申请号：US15070549
申请日：2016-03-15
Applicant: Pfizer Inc.
Inventor： Andreas MADERNA , Chakrapani SUBRAMANYAM , Lawrence N. TUMEY , Zecheng CHEN , Jeffrey M. CASAVANT
IPC: A61K47/48 , C07F9/6561 , C07K16/32 , C07K5/09 , C07B59/00 , C07K16/28 , C07D519/00 , C07K5/062
CPC classification number: C07K16/32 , A61K47/65 , A61K47/6803 , A61K47/6807 , A61K47/6849 , A61K47/6863 , A61K47/6865 , A61K47/6869 , A61K47/6871 , C07B59/002 , C07B2200/05 , C07D495/04 , C07D519/00 , C07F9/6561 , C07K5/06052 , C07K5/0815 , C07K16/2803 , C07K16/2866
Abstract: The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F1-L1-T-L2-F2 where F1, L1, T, L2 and F2 are as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs; and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.
Abstract translation: 其中F1，L1，T，L2和F2如本文所定义，可用于治疗增殖性疾病，其中本发明的二聚体可用作独立药物，抗体 - 药物共轭物（ADC）中的有效载荷和接头有效载体 可用于生产或管理此类ADC的化合物; 以及包含上述二聚体，连接物有效载体和ADC的组合物，以及使用这些二聚体，连接体有效载体和ADC的方法来治疗包括癌症在内的病理状况。
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公开(公告)号：US20230382932A1
公开(公告)日：2023-11-30
申请号：US18225589
申请日：2023-07-24
Applicant: PFIZER INC.
Inventor： Martin James WYTHES , Indrawan James MCALPINE , Ryan PATMAN , Eugene Yuanjin RUI , Andrew FENSOME , Andreas MADERNA , Mehran JALAIE , Ketan S. GAJIWALA
IPC: C07F9/6574 , A61K47/68 , A61P35/00 , C07H19/213
CPC classification number: C07F9/65744 , A61K47/6801 , A61P35/00 , C07H19/213
Abstract: Compounds of the general formula (I):
or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.-
公开(公告)号：US20190233440A1
公开(公告)日：2019-08-01
申请号：US16263185
申请日：2019-01-31
Applicant: PFIZER INC.
Inventor： Simon PLANKEN , Hengmiao CHENG , Michael Raymond COLLINS , Jillian Elyse SPANGLER , Alexei BROOUN , Andreas MADERNA , Cynthia PALMER , Maria Angelica LINTON , Asako NAGATA , Ping CHEN
IPC: C07D519/00 , C07D471/04 , C07D403/14 , C07D487/10 , C07D487/04 , C07D417/14 , A61P35/00
Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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Patent Agency Ranking
公开(公告)号：US20150209445A1
公开(公告)日：2015-07-30
申请号：US14605697
申请日：2015-01-26
Applicant: Pfizer Inc.
Inventor： Andreas MADERNA , Matthew David DOROSKI , Zecheng CHEN , Hud Lawrence RISLEY , Jeffrey Michael CASAVANT , Christopher John O'DONNELL , Alexander M. PORTE , Chakrapani SUBRAMANYAM
IPC: A61K47/48 , A61K31/404 , A61K31/4439 , C07D401/14 , C07D409/14 , A61K31/675 , C07F9/6561 , A61K31/454 , A61K31/7056 , C07H17/02 , C07D417/14 , A61K31/433 , A61K31/407 , C07D487/04 , C07K5/08 , C07K5/06 , C07K9/00 , A61K38/05 , A61K38/06 , C07D405/14
CPC classification number: A61K47/48384 , A61K31/404 , A61K31/407 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/675 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K47/6803 , A61K47/6807 , A61K47/6811 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07F9/6561 , C07H17/02 , C07K5/06 , C07K5/08 , C07K9/003
Abstract: Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
Abstract translation: 包含基于CBI和/或CPI的亚单位的细胞毒性二聚体，包含这种二聚体的抗体药物偶联物，以及使用该二聚体治疗癌症和其它病症的方法。
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公开(公告)号：US20130129753A1
公开(公告)日：2013-05-23
申请号：US13670612
申请日：2012-11-07
Applicant: PFIZER INC.
Inventor： Matthew David DOROSKI , Andreas MADERNA , Christopher John O'DONNELL , Chakrapani SUBRAMANYAM , Beth VETELINO , Russell George DUSHIN , Pavel STROP , Edmund Idris GRAZIANI
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
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公开(公告)号：US20210061923A1
公开(公告)日：2021-03-04
申请号：US17091097
申请日：2020-11-06
Applicant: PFIZER INC.
Inventor： Andreas MADERNA , Chakrapani SUBRAMANYAM , Lawrence N. TUMEY , Zecheng CHEN , Jeffrey M. CASAVANT
IPC: C07K16/32 , C07D519/00 , C07F9/6561 , C07K5/062 , C07K5/09 , C07B59/00 , C07K16/28 , C07D495/04 , A61K47/68 , A61K47/65
Abstract: The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F1-L1-T-L2-F2 where F1, L1, T, L2 and F2 are as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs; and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.
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公开(公告)号：US20190248767A1
公开(公告)日：2019-08-15
申请号：US16265012
申请日：2019-02-01
Applicant: PFIZER INC.
Inventor： Simon PLANKEN , Hengmiao CHENG , Michael Raymond COLLINS , Jillian Elyse SPANGLER , Alexei BROOUN , Andreas MADERNA , Cynthia PALMER , Maria Angelica LINTON , Asako NAGATA , Ping CHEN
IPC: C07D403/14 , C07D487/10 , A61P35/00
Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20180339060A1
公开(公告)日：2018-11-29
申请号：US16053344
申请日：2018-08-02
Applicant: PFIZER INC.
Inventor： Andreas MADERNA , Matthew David DOROSKI , Zecheng CHEN , Hud Lawrence RISLEY , Jeffrey Michael CASAVANT , Christopher John O'DONNELL , Alexander M. PORTE , Chakrapani SUBRAMANYAM
IPC: A61K47/68 , C07K9/00 , C07K5/06 , C07H17/02 , C07F9/6561 , C07D487/04 , C07D417/14 , C07D409/14 , C07D405/14 , C07D401/14 , A61K38/06 , A61K38/05 , A61K31/7056 , A61K31/675 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/407 , A61K31/404 , C07K5/08
CPC classification number: A61K47/6851 , A61K31/404 , A61K31/407 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/675 , A61K31/7056 , A61K38/05 , A61K38/06 , A61K47/6803 , A61K47/6807 , A61K47/6811 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07F9/6561 , C07H17/02 , C07K5/06 , C07K5/08 , C07K9/003
Abstract: Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
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