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公开(公告)号：US20240174742A1
公开(公告)日：2024-05-30
申请号：US18511744
申请日：2023-11-16
Applicant: PFIZER INC. , The Brigham and Women's Hospital, Inc.
Inventor： Stefano V. Gulla , Christine Huard , Janet Elizabeth Buhlmann , Juan Carlos Almagro , Sreekumar R. Kodangattil , Steven A. Greenberg , Edward Roland Lavallie , Eric M. Bennett , Lidia Mosyak , James Perry Hall , Anthony John Coyle
CPC classification number: C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are are useful for various therapeutic or diagnostic purposes.
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公开(公告)号：US20210324028A1
公开(公告)日：2021-10-21
申请号：US17356754
申请日：2021-06-24
Applicant: Pfizer Inc.
Inventor： Yik Andy Yeung , Reid Martin Renny Feldman , Ling Hon Matthew Chu , Javier Fernando Chaparro Riggers , Ivana Djuretic , Laura Lin , Lidia Mosyak
IPC: C07K14/54 , A61K35/17 , C07K19/00 , A61P35/00 , A61K38/17 , C07K16/32 , C07K16/28 , C07K14/55 , C12N15/62 , A61K38/19 , A61K39/395 , A61K38/20
Abstract: The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.
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公开(公告)号：US11059876B2
公开(公告)日：2021-07-13
申请号：US16286158
申请日：2019-02-26
Applicant: Pfizer Inc.
Inventor： Yik Andy Yeung , Reid Martin Renny Feldman , Ling Hon Matthew Chu , Javier Fernando Chaparro Riggers , Ivana Djuretic , Laura Lin , Lidia Mosyak
IPC: C07K14/54 , A61K39/395 , A61K38/17 , A61K38/20 , A61K35/17 , C07K19/00 , A61P35/00 , C07K16/32 , C07K16/28 , C07K14/55 , C12N15/62 , A61K38/19 , A61K45/06
Abstract: The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.
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公开(公告)号：US10829553B2
公开(公告)日：2020-11-10
申请号：US15581079
申请日：2017-04-28
Applicant: PFIZER INC. , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Stefano V. Gulla , Christine Huard , Janet Elizabeth Buhlmann , Juan Carlos Almagro , Sreekumar R. Kodangattil , Steven A. Greenberg , Edward Roland Lavallie , Eric M. Bennett , Lidia Mosyak , James Perry Hall , Anthony John Coyle
Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes.
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公开(公告)号：US20180155452A1
公开(公告)日：2018-06-07
申请号：US15840019
申请日：2017-12-13
Applicant: Pfizer Inc.
Inventor： Chad Michael May , Adam Reid Root , William A. Brady , Lioudmila Gennadievna Tchistiakova , Lidia Mosyak , Laird Bloom , Paul A. Moore , Leslie S. Johnson
CPC classification number: C07K16/468 , C07K16/18 , C07K16/28 , C07K16/2809 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/94
Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.
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Patent Agency Ranking
公开(公告)号：US11525010B2
公开(公告)日：2022-12-13
申请号：US16417863
申请日：2019-05-21
Applicant: Pfizer Inc.
Inventor： Chew Shun Chang , Gurkan Guntas , Madan Katragadda , Divya Mathur , Adam Reid Root , Lidia Mosyak , Edward Roland LaVallie
Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.
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公开(公告)号：US20210163588A1
公开(公告)日：2021-06-03
申请号：US17092998
申请日：2020-11-09
Applicant: PFIZER INC. , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Stefano V. Gulla , Christine Huard , Janet Elizabeth Buhlmann , Juan Carlos Almagro , Sreekumar R. Kodangattil , Steven A. Greenberg , Edward Roland Lavallie , Eric M. Bennett , Lidia Mosyak , James Perry Hall , Anthony John Coyle
IPC: C07K16/24
Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are are useful for various therapeutic or diagnostic purposes.
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公开(公告)号：US20200010566A1
公开(公告)日：2020-01-09
申请号：US16417863
申请日：2019-05-21
Applicant: Pfizer Inc.
Inventor： Chew Shun Chang , Gurkan Guntas , Madan Katragadda , Divya Mathur , Adam Reid Root , Lidia Mosyak , Edward Roland LaVallie
Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.
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公开(公告)号：US09884921B2
公开(公告)日：2018-02-06
申请号：US14751704
申请日：2015-06-26
Applicant: Pfizer Inc.
Inventor： Chad Michael May , Adam Reid Root , William A. Brady , Lioudmila Gennadievna Tchistiakova , Lidia Mosyak , Laird Bloom , Paul A. Moore , Leslie S. Johnson
CPC classification number: C07K16/468 , C07K16/18 , C07K16/28 , C07K16/2809 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/94
Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.
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公开(公告)号：US20240209061A1
公开(公告)日：2024-06-27
申请号：US17908822
申请日：2021-03-05
Applicant: Pfizer Inc.
Inventor： Eric Matthew Bennett , Christina Hwei-Lin Eng , Laura Lin Lohse , Lidia Mosyak , Jeremy Shawn Myers , Mohosin Sarkar , Hayretin Rafet Yumerefendi
IPC: C07K14/705 , A61K31/5025 , A61K39/395 , A61P35/00 , C07K16/28
CPC classification number: C07K14/70532 , A61K31/5025 , A61K39/3955 , A61P35/00 , C07K16/2818 , C07K2317/94 , C07K2319/30
Abstract: The present invention provides for CD80-Fc fusion proteins that have therapeutic and diagnostic use, and methods for making thereof. The present invention further relates to variant CD80 polypeptides. The present invention also provides for CD80-Fc fusion proteins for use in the treatment of cancer.
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