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公开(公告)号：US09717755B2
公开(公告)日：2017-08-01
申请号：US13637775
申请日：2011-04-01
申请人： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett , Humayra Begum Ali
发明人： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett , Humayra Begum Ali
IPC分类号： A61K31/745 , A61K31/74 , A61K31/75 , A61K9/00 , A61K47/48
CPC分类号： A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
摘要： The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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2.发明申请Polymeric Sorbent for Removal of Impurities From Whole Blood and Blood Products 审中-公开用于从全血和血液制品中去除杂质的聚合物吸附剂公开(公告)号：US20130011824A1
公开(公告)日：2013-01-10
申请号：US13344166
申请日：2012-01-05
CPC分类号： A01N1/0263 , A01N1/0278 , B01J20/267 , B01J20/28004 , B01J20/28069 , B01J20/28078 , B01J20/3208 , B01J20/327 , B01J20/3272 , B01J20/328 , Y10T29/49826 , Y10T428/2982
摘要： The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.
摘要翻译： 本发明涉及治疗血液，血液制品或生理液体以最大化保质期和/或最小化输血相关并发症的方法，例如非溶血性输血反应，例如发热，输血相关性急性肺损伤（TRALI），输血相关呼吸困难（TAD） ），以及通过使用吸附剂去除血液，血液制品或生理流体环境中不需要的分子的过敏反应。
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公开(公告)号：US10064406B2
公开(公告)日：2018-09-04
申请号：US13344166
申请日：2012-01-05
摘要： The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.
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4.发明申请COMPOSITIONS AND METHODS USEFUL IN SELECTIVELY MODIFYING THE INTERNAL AND EXTERNAL SURFACES OF POROUS POLYMER BEADS 有权组合物和方法有选择地修改多孔聚合物珠的内部和外部表面公开(公告)号：US20140042097A1
公开(公告)日：2014-02-13
申请号：US13978218
申请日：2012-01-06
IPC分类号： A61M1/36
CPC分类号： A61M1/3679 , B01J20/267 , B01J20/28019 , B01J20/3208 , B01J20/3248 , B01J20/3285 , C08F8/00
摘要： The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
摘要翻译： 本发明涉及包含至少一种具有多个孔的聚合物的聚合物体系，其中聚合物在基本上所有表面上最初被官能化，随后是逐步表面特异官能化，使得不同的官能团位于珠的外部或内部孔表面上。 本发明还涉及在血液，血液制品或生理液体纯化中使用这种聚合物体系。
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公开(公告)号：US10426158B2
公开(公告)日：2019-10-01
申请号：US14238548
申请日：2012-08-10
IPC分类号： A01N1/02 , B01J20/26 , B01J20/28 , C08F236/20
摘要： The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
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公开(公告)号：US09931457B2
公开(公告)日：2018-04-03
申请号：US13978218
申请日：2012-01-06
CPC分类号： A61M1/3679 , B01J20/267 , B01J20/28019 , B01J20/3208 , B01J20/3248 , B01J20/3285 , C08F8/00
摘要： The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
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