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公开(公告)号：US09717755B2
公开(公告)日：2017-08-01
申请号：US13637775
申请日：2011-04-01
申请人： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett , Humayra Begum Ali
发明人： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett , Humayra Begum Ali
IPC分类号： A61K31/745 , A61K31/74 , A61K31/75 , A61K9/00 , A61K47/48
CPC分类号： A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
摘要： The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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2.发明申请Polymeric Sorbent for Removal of Impurities From Whole Blood and Blood Products 审中-公开用于从全血和血液制品中去除杂质的聚合物吸附剂公开(公告)号：US20130011824A1
公开(公告)日：2013-01-10
申请号：US13344166
申请日：2012-01-05
CPC分类号： A01N1/0263 , A01N1/0278 , B01J20/267 , B01J20/28004 , B01J20/28069 , B01J20/28078 , B01J20/3208 , B01J20/327 , B01J20/3272 , B01J20/328 , Y10T29/49826 , Y10T428/2982
摘要： The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.
摘要翻译： 本发明涉及治疗血液，血液制品或生理液体以最大化保质期和/或最小化输血相关并发症的方法，例如非溶血性输血反应，例如发热，输血相关性急性肺损伤（TRALI），输血相关呼吸困难（TAD） ），以及通过使用吸附剂去除血液，血液制品或生理流体环境中不需要的分子的过敏反应。
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公开(公告)号：US10064406B2
公开(公告)日：2018-09-04
申请号：US13344166
申请日：2012-01-05
摘要： The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.
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4.发明申请COMPOSITIONS AND METHODS USEFUL IN SELECTIVELY MODIFYING THE INTERNAL AND EXTERNAL SURFACES OF POROUS POLYMER BEADS 有权组合物和方法有选择地修改多孔聚合物珠的内部和外部表面公开(公告)号：US20140042097A1
公开(公告)日：2014-02-13
申请号：US13978218
申请日：2012-01-06
IPC分类号： A61M1/36
CPC分类号： A61M1/3679 , B01J20/267 , B01J20/28019 , B01J20/3208 , B01J20/3248 , B01J20/3285 , C08F8/00
摘要： The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
摘要翻译： 本发明涉及包含至少一种具有多个孔的聚合物的聚合物体系，其中聚合物在基本上所有表面上最初被官能化，随后是逐步表面特异官能化，使得不同的官能团位于珠的外部或内部孔表面上。 本发明还涉及在血液，血液制品或生理液体纯化中使用这种聚合物体系。
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公开(公告)号：US20130195792A1
公开(公告)日：2013-08-01
申请号：US13637775
申请日：2011-04-01
IPC分类号： A61K31/745
CPC分类号： A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
摘要： The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
摘要翻译： 本发明涉及从患有或处于炎症风险的患者处理全身，局部或局部炎症的方法，其包括施用治疗有效剂量的吸附所述患者中的炎性介质的吸附剂。 在一些优选实施方案中，吸附剂是生物相容性有机聚合物。
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公开(公告)号：US10426158B2
公开(公告)日：2019-10-01
申请号：US14238548
申请日：2012-08-10
IPC分类号： A01N1/02 , B01J20/26 , B01J20/28 , C08F236/20
摘要： The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
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公开(公告)号：US09931457B2
公开(公告)日：2018-04-03
申请号：US13978218
申请日：2012-01-06
CPC分类号： A61M1/3679 , B01J20/267 , B01J20/28019 , B01J20/3208 , B01J20/3248 , B01J20/3285 , C08F8/00
摘要： The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
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8.发明申请POLYMERIC SORBENT FOR REMOVAL OF IMPURITIES FROM WHOLE BLOOD AND BLOOD PRODUCTS 审中-公开用于从全血和血液制品中清除污染物的聚合物溶液公开(公告)号：US20150118673A1
公开(公告)日：2015-04-30
申请号：US14238548
申请日：2012-08-10
IPC分类号： A01N1/02 , B01J20/28 , C08F236/20 , B01J20/26
CPC分类号： A01N1/021 , B01J20/267 , B01J20/28016 , B01J20/28073 , B01J20/28076 , B01J20/2808 , B01J20/28083 , B01J20/28085 , C08F236/20
摘要： The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
摘要翻译： 本发明涉及治疗储存血液和血液制品的方法，其最大化保质期和/或最小化输血相关并发症，例如非溶血性输血反应，例如发烧，输血相关急性肺损伤（TRALI），输血相关性呼吸困难（TAD）和 通过使用吸附剂去除血液和血液制品环境中的不合需要的分子来进行过敏反应。
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公开(公告)号：US07629049B2
公开(公告)日：2009-12-08
申请号：US11710844
申请日：2007-02-26
CPC分类号： C09D105/10 , C08K5/0025 , C08L25/16 , C08L39/06 , C08L2205/08 , C09D101/284 , C09D101/286 , C09D105/00 , C09D105/08 , C09D189/00 , Y10T428/2991 , Y10T428/2998 , Y10T428/31504 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , Y10T428/31971 , C08L2666/04
摘要： A polymer system and device with a hemocompatible film or coated polymers is provided, the polymer system comprises an organic phase and an aqueous phase, the organic phase comprises polymerizable monomers and at least one initiator and the aqueous phase comprises at least one dispersing agent, at least one free radical inhibitor and at least one buffering agent, the organic phase is immiscible in the aqueous phase, and the dispersing agent forms a hemocompatible surface on the polymer, and the device comprises a housing for containing the polymer system.
摘要翻译： 提供了具有血液相容性膜或涂覆聚合物的聚合物体系和装置，聚合物体系包含有机相和水相，有机相包含可聚合单体和至少一种引发剂，水相包含至少一种分散剂， 至少一种自由基抑制剂和至少一种缓冲剂，所述有机相在所述水相中是不混溶的，并且所述分散剂在所述聚合物上形成血液相容性表面，并且所述装置包括用于容纳所述聚合物体系的壳体。
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公开(公告)号：US09604196B2
公开(公告)日：2017-03-28
申请号：US13506875
申请日：2012-05-22
CPC分类号： B01J20/267 , A61M1/3679 , B01D15/34 , B01J20/261 , B01J20/262 , B01J20/28069 , B01J20/28078 , B01J20/2808 , B01J20/28083 , B01J20/28085 , B01J20/28088 , B01J20/3208 , B01J20/327 , B01J20/3272
摘要： A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one crosslinking agent and at least one dispersing agent, and the polymer has a plurality of pores with diameters in the range from about 17 to about 40,000 Angstroms.
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