公开(公告)号：US20240321356A1

公开(公告)日：2024-09-26

申请号：US18733444

申请日：2024-06-04

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Itzhak TAMO ,  Alon AKIVA

IPC: G11C13/02 ,  G16B30/20

CPC classification number: G11C13/02 ,  G16B30/20

Abstract: Methods of storing information in a living organism are provided. Systems and computer program products for performing the methods are also provided.

公开(公告)号：US20240368700A1

公开(公告)日：2024-11-07

申请号：US18562317

申请日：2022-05-19

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Tal GUTMAN

IPC: C12Q1/6886 ,  G16B20/00 ,  G16B40/20

Abstract: Methods of determining a type of cancer in a subject or estimating survival time after diagnosis of a subject comprising employing a machine learning model to evaluate mutations that are not exonic non-synonymous mutations are provided. Methods comprising training a machine learning model are also provided.

公开(公告)号：US20240282402A1

公开(公告)日：2024-08-22

申请号：US18641391

申请日：2024-04-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  David SHALLOM ,  Shlomo WEISS ,  Danny NAIGER

IPC: G16B5/00

CPC classification number: G16B5/00

Abstract: A system and method of whole-cell process simulations may include: using at least one first hardware module, to produce a first predicted value, representing an expected behavior of a plurality of resource entities in a simulated biological cell; using at least one second hardware module, to produce a second predicted value, representing an interaction of a plurality of client entities with at least one of the plurality of resource entities in the simulated biological cell; using at least one third hardware module, to produce a third predicted value, representing an arbitration of interactions between the plurality of resource entities and the plurality of client entities in the simulated biological cell; and producing a simulated value of a product of a natural process in the simulated biological cell, based on said first, second and third predicted values.

公开(公告)号：US20230230658A1

公开(公告)日：2023-07-20

申请号：US18123413

申请日：2023-03-20

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tamir TULLER ,  Hadas ZUR

IPC: G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C12N15/10 ,  G06F17/00 ,  G06F17/10 ,  G06F17/15 ,  G06F17/17

CPC classification number: G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C12N15/1089 ,  G06F17/00 ,  G06F17/10 ,  G06F17/15 ,  G06F17/17

Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.

公开(公告)号：US20230167476A1

公开(公告)日：2023-06-01

申请号：US17921035

申请日：2021-04-22

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Matan ARBEL ,  Itamar MENUHIN ,  Itai KATZIR ,  Shaked BERGMAN ,  Doron NAKI

IPC: C12P21/00 ,  G16B40/00 ,  C12N15/81

CPC classification number: C12P21/00 ,  G16B40/00 ,  C12N15/81

Abstract: The present invention is directed to a chimeric polypeptide including a polypeptide of interest N-terminal to an essential protein of a target cell. Further provided is a polynucleotide encoding the chimeric polypeptide, a method of producing thereof, and a method for producing a protein of interest. The chimeric polypeptide of the invention improves the genetic stability of the polypeptide of interest ensuring its expression over time.

公开(公告)号：US20180273911A1

公开(公告)日：2018-09-27

申请号：US15764691

申请日：2016-09-29

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir TULLER ,  Eli GOZ ,  Shimshi ATAR ,  Hadas ZUR

IPC: C12N7/00 ,  A61K39/12

CPC classification number: C12N7/00 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5254 ,  C12N2770/24121 ,  C12N2770/24162 ,  G16B99/00 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/391 ,  Y02A50/465

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

公开(公告)号：US20250043278A1

公开(公告)日：2025-02-06

申请号：US18928324

申请日：2024-10-28

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Ofek SCHNITZER ,  Hadas ZUR ,  Zohar ZAFRIR

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/67 ,  C12Q1/6886

Abstract: The present invention is directed to a method for treating cancer in a subject determined as having the presence of a G600>A substitution, a C601>T substitution, or both, in the B cell lymphoma 2 (BCL2) gene of a cell.

公开(公告)号：US20220098598A1

公开(公告)日：2022-03-31

申请号：US17552720

申请日：2021-12-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  Hadas ZUR ,  Rachel COHEN-KUPIEC

IPC: C12N15/67 ,  C12Q1/6809 ,  C12N15/79

Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.

公开(公告)号：US20220010287A1

公开(公告)日：2022-01-13

申请号：US17467265

申请日：2021-09-05

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir TULLER ,  Eli GOZ ,  Shimshi ATAR ,  Hadas ZUR

IPC: C12N7/00 ,  G16B99/00 ,  C12N7/04 ,  G16B15/10 ,  A61K39/12

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

公开(公告)号：US20240304282A1

公开(公告)日：2024-09-12

申请号：US18585138

申请日：2024-02-23

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER

IPC: G16B30/20

CPC classification number: G16B30/20

Abstract: Computerized methods for engineering a nucleic acid molecule comprising a coding region optimized for expression in a first set of organisms and deoptimized for expression in a second set of organisms are provided.