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公开(公告)号：US20100178691A1
公开(公告)日：2010-07-15
申请号：US12730121
申请日：2010-03-23
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6432
摘要： An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for detecting the fluorescently labeled molecule.
摘要翻译： 实施方案一般涉及用于分析分析物的系统。 该系统可以包括透明基板。 该系统还包括激发光源，其被配置为在靠近透明衬底的位置处诱导荧光标记分子的ev逝波激发和用于检测荧光标记分子的检测器。
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公开(公告)号：US07709808B2
公开(公告)日：2010-05-04
申请号：US11749411
申请日：2007-05-16
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6432
摘要： An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for detecting the fluorescently labeled molecule.
摘要翻译： 实施方案一般涉及用于分析分析物的系统。 该系统可以包括透明基板。 该系统还包括激发光源，其被配置为在靠近透明衬底的位置处诱导荧光标记分子的ev逝波激发和用于检测荧光标记分子的检测器。
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公开(公告)号：US20080105831A1
公开(公告)日：2008-05-08
申请号：US11749411
申请日：2007-05-16
IPC分类号： G01J1/58
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6432
摘要： An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for detecting the fluorescently labeled molecule.
摘要翻译： 实施方案一般涉及用于分析分析物的系统。 该系统可以包括透明基板。 该系统还包括激发光源，其被配置为在靠近透明衬底的位置处诱导荧光标记分子的ev逝波激发和用于检测荧光标记分子的检测器。
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公开(公告)号：US08834797B2
公开(公告)日：2014-09-16
申请号：US12384516
申请日：2009-04-06
申请人： Mark F. Oldham , Eric S. Nordman , Hongye Sun , Steven J. Boege
发明人： Mark F. Oldham , Eric S. Nordman , Hongye Sun , Steven J. Boege
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N21/6456
摘要： A scanning detection system is provided in which emissions from locations in a flow cell are detected. In some embodiments, the system can include an excitation source, a photocleavage source, and modulating optics configured to cause an excitation beam generated by the excitation source to irradiate a first group of the fixed locations and to cause a photocleavage beam generated by the photocleavage source to irradiate a second group of the fixed locations, which is separate and apart from the first group of fixed locations. Methods of detecting sequencing reactions using such a system are also provided.
摘要翻译： 提供了一种扫描检测系统，其中检测到流动池中的位置的发射。 在一些实施例中，系统可以包括激发源，光切割源和调制光学器件，其被配置为使得由激发源产生的激发光束照射第一组固定位置并引起由光切割源产生的光切割束 以照射与第一组固定位置分开并分开的第二组固定位置。 还提供了使用这种系统检测测序反应的方法。
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公开(公告)号：US20090250615A1
公开(公告)日：2009-10-08
申请号：US12384516
申请日：2009-04-06
申请人： Mark F. Oldham , Eric S. Nordman , Hongye Sun , Steven J. Boege
发明人： Mark F. Oldham , Eric S. Nordman , Hongye Sun , Steven J. Boege
IPC分类号： G01T1/20
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N21/6456
摘要： A scanning detection system is provided wherein emissions from locations in a flow cell are detected. In some embodiments, the system can comprise an excitation source, a photocleavage source, and modulating optics configured to cause an excitation beam generated by the excitation source to irradiate a first group of the fixed locations and to cause a photocleavage beam generated by the photocleavage source to irradiate a second group of the fixed locations, which is separate and apart from the first group of fixed locations. Methods of detecting sequencing reactions using such a system are also provided.
摘要翻译： 提供了一种扫描检测系统，其中检测到来自流动池中的位置的发射。 在一些实施例中，系统可以包括激发源，光切割源和调制光学器件，其被配置为使得由激发源产生的激发光束照射第一组固定位置并引起由光切割源产生的光致剪切光束 以照射与第一组固定位置分开并分开的第二组固定位置。 还提供了使用这种系统检测测序反应的方法。
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公开(公告)号：US07407798B2
公开(公告)日：2008-08-05
申请号：US11096341
申请日：2005-03-31
申请人： Mark F. Oldham , Richard T. Reel , Steven J. Boege
发明人： Mark F. Oldham , Richard T. Reel , Steven J. Boege
CPC分类号： G01N21/6452 , B01L7/52 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , G01N21/253 , G02B3/0056 , G02B3/08
摘要： The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having a plurality of focusing lens segments greater than the plurality of biological samples to direct light into the plurality of biological samples.
摘要翻译： 本发明涉及一种用于热循环装置的光学检测系统，其包括至少一个光源，用于检测从多个生物样本接收的光的光检测装置，以及具有大于多个生物样本的多个聚焦透镜段的透镜 生物样品将光引导到多个生物样品中。
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公开(公告)号：US08492138B2
公开(公告)日：2013-07-23
申请号：US13611462
申请日：2012-09-12
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
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公开(公告)号：US07387891B2
公开(公告)日：2008-06-17
申请号：US10440719
申请日：2003-05-19
申请人： Steven J. Boege , Mark F. Oldham , Eugene F. Young
发明人： Steven J. Boege , Mark F. Oldham , Eugene F. Young
CPC分类号： G01N21/6452 , B01L7/52 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0628 , G01N2201/0635 , Y10S435/808
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to form bundles of collimated excitation beams, wherein each bundle corresponds to a respective reaction region. Methods of analysis using the optical instrument are also provided.
摘要翻译： 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多间隔开的反应区域。 准直透镜可以沿着光源和反应区域之间的光束路径设置，以形成准直激励束的束，其中每个束对应于相应的反应区域。 还提供了使用光学仪器的分析方法。
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公开(公告)号：US09285318B2
公开(公告)日：2016-03-15
申请号：US13619679
申请日：2012-09-14
申请人： Steven J. Boege , Mark F. Oldham , Eugene F. Young
发明人： Steven J. Boege , Mark F. Oldham , Eugene F. Young
IPC分类号： G01N21/00 , G01N21/64 , F21K99/00 , G01J3/10 , G01J3/02 , F21V29/54 , F21V29/67 , F21V29/74 , G05D23/19 , G05D23/20 , F21Y101/02
CPC分类号： G01N21/64 , F21K9/00 , F21K9/64 , F21V29/54 , F21V29/677 , F21V29/74 , F21Y2115/10 , G01J3/0286 , G01J3/10 , G01N21/645 , G01N21/6452 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2201/0638 , G01N2201/1211 , G05D23/1919 , G05D23/20
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to form bundles of collimated excitation beams, wherein each bundle corresponds to a respective reaction region. Methods of analysis using the optical instrument are also provided.
摘要翻译： 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多间隔开的反应区域。 准直透镜可以沿着光源和反应区域之间的光束路径设置，以形成准直激励束的束，其中每个束对应于相应的反应区域。 还提供了使用光学仪器的分析方法。
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公开(公告)号：US08557569B2
公开(公告)日：2013-10-15
申请号：US12217410
申请日：2008-07-03
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
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