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    Soluble analyte detection and amplification
    3.
    发明申请
    Soluble analyte detection and amplification 有权
    可溶性分析物检测和扩增

    公开(公告)号：US20050048500A1

    公开(公告)日：2005-03-03

    申请号：US10653321

    申请日：2003-09-02

    申请人： Robert Lawton

    发明人： Robert Lawton

    IPC分类号： C12N20060101 ,  C12Q1/68

    CPC分类号： C12Q1/6804 ,  Y10S435/971 ,  Y10S435/973 ,  C12Q2563/173 ,  C12Q2563/179

    摘要： The present invention relates to a method of detection of a compound of interest that is present at low levels in a sample. In particular, the present invention relates to a method of detection of a compound of interest in solution by a nucleic acid-labelled binding construct, separation of the unbound nucleic acid-labelled binding construct, and the detection of the bound nucleic acid-labelled binding construct in the solution phase. The present invention is particularly adaptable to be used in conjunction with a nucleic acid amplification reaction for detecting the presence or absence of the nucleic acid portion of binding construct in a sample indicating the presence or absence of the compound of interest.

    摘要翻译： 本发明涉及一种在样本中以低水平存在的感兴趣化合物的检测方法。 特别地，本发明涉及通过核酸标记的结合构建体检测溶液中感兴趣的化合物的方法，分离未结合的核酸标记的结合构建体和检测结合的核酸标记的结合 在溶液相中构建。 本发明特别适合与核酸扩增反应结合使用，用于检测在表明存在或不存在目的化合物的样品中结合构建体的核酸部分的存在或不存在。

    Dynamic program module generation for manipulating vehicle frame
    5.
    发明申请
    Dynamic program module generation for manipulating vehicle frame 有权
    用于操纵车架的动态程序模块生成

    公开(公告)号：US20070220482A1

    公开(公告)日：2007-09-20

    申请号：US11385262

    申请日：2006-03-20

    申请人： Kevin O'Sullivan ,  James Rhodes ,  Robert Lawton ,  William Layman

    发明人： Kevin O'Sullivan ,  James Rhodes ,  Robert Lawton ,  William Layman

    IPC分类号： G06F9/44

    CPC分类号： G05B19/4093 ,  G05B19/41845 ,  G05B2219/45013 ,  Y02P90/04 ,  Y02P90/16 ,  Y02P90/265

    摘要： A system and method for generating a set of programming instructions for manipulating a vehicle frame are provided. A frame computing device obtains configuration information for an identified vehicle frame. The frame computing device sub-divides the selected vehicle frame into a set of regions and obtains programming modules for each of the components mounted in the set of regions. The frame computing device processes the program modules to generate a cumulative set of programming instructions for manipulating the vehicle frame.

    摘要翻译： 提供了一种用于产生用于操纵车辆框架的编程指令的集合的系统和方法。 帧计算装置获取所识别的车辆帧的配置信息。 帧计算装置将所选择的车辆帧划分为一组区域，并获得安装在该组区域中的每个组件的编程模块。 帧计算装置处理程序模块以生成用于操纵车辆框架的累积编程指令集。

    Methods for using canine immunoglobulin variable domains and caninized antibodies
    8.
    发明授权
    Methods for using canine immunoglobulin variable domains and caninized antibodies 失效
    使用犬免疫球蛋白可变结构域和可分化抗体的方法

    公开(公告)号：US07261890B2

    公开(公告)日：2007-08-28

    申请号：US10327598

    申请日：2002-12-20

    申请人： Eugene Regis Krah, III ,  Hongliang Guo ,  Ashok Aiyappa ,  Robert Lawton

    发明人： Eugene Regis Krah, III ,  Hongliang Guo ,  Ashok Aiyappa ,  Robert Lawton

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C12P21/04 ,  C12P21/08

    CPC分类号： C07K16/4291 ,  A61K2039/505 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2319/00

    摘要： The present invention provides canine heavy chain and light chain (both λ and κ) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presently disclosed canine variable domain framework sequences and CDRs specific for an antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This disclosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninization permits the development of useful therapeutics, which includes but is not limited to allergy, osteosarcomma's and lymphomma's.

    摘要翻译： 本发明提供犬重链和轻链（λ和κ）可变结构域核酸和多肽。 本发明还提供了由本发明的犬可变结构域框架序列组成的包含抗体的抗体，以及从犬以外的抗体（优选小鼠）获得的抗原特异性CDR。 本发明还提供了制造可以抗体的抗体并使用它们的方法。 该公开内容具体描述了可用于治疗犬过敏症的耐受性抗体。 罐头化的一般过程允许开发有用的治疗剂，其包括但不限于变态反应，骨肉瘤和淋巴瘤。