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公开(公告)号：US20210381987A1
公开(公告)日：2021-12-09
申请号：US17405742
申请日：2021-08-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter JOSEL , Herbert ANDRES , Michaela WINDFUHR , Oliver LARBOLETTE , Stefan QUINT
IPC: G01N21/76 , G01N33/543 , C07F15/00 , G01N21/66
Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
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公开(公告)号：US20220283094A1
公开(公告)日：2022-09-08
申请号：US17631061
申请日：2019-07-31
Inventor： Toshiro SAITO , Kyoko IMAI , Francesco PAOLUCCI , Massimo MARCACCIO , Giovanni VALENTI , Alessandra ZANUT , Michaela WINDFUHR , Hans-Peter JOSEL
IPC: G01N21/66 , G01N33/543 , B01L3/00
Abstract: An analysis method includes: an inflow process of a solution containing a test object, a magnetic support on the surface of which a complex including an antibody labeled with a luminescent agent and recognizes the test object is formed, and a reaction aid to assist reaction of the luminescent agent in a flow cell; a process of capturing the magnetic support over a working electrode by a magnetic field; a process of making the luminescent agent illuminate by applying a voltage to the working electrode; and a process of measuring an amount of luminescence of the luminescent agent. The luminescent process includes: luminescence from action of a first neutral radical, produced from the reaction aid through a cation radical; and luminescence from action of a second neutral radical, produced not through a cation radical, on the luminescent agent. This increases the luminous efficiency of ECL and enhances detection sensitivity.
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公开(公告)号：US20240377388A1
公开(公告)日：2024-11-14
申请号：US18669957
申请日：2024-05-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael GERG , Dieter HEINDL , Lars HILLRINGHAUS , Klaus HIRZEL , Caroline Dorothea HOJER , Florian HUBER , Hans-Peter JOSEL , Thomas MEIER , Michael SCHRAEML , Edgar VOSS
IPC: G01N33/543 , C07K16/44
Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
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Patent Agency Ranking
公开(公告)号：US20220106408A1
公开(公告)日：2022-04-07
申请号：US17551732
申请日：2021-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael GERG , Lars HILLRINGHAUS , Klaus HIRZEL , Caroline Dorothea HOJER , Hans-Peter JOSEL , Christoph SEIDEL , Michael SCHRAEML , Leopold VON PROFF
IPC: C07K16/44 , G01N33/543 , C07K16/40 , C07K16/00 , G01N33/82
Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
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公开(公告)号：US20220107310A1
公开(公告)日：2022-04-07
申请号：US17551723
申请日：2021-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael GERG , Dieter HEINDL , Lars HILLRINGHAUS , Klaus HIRZEL , Caroline Dorothea HOJER , Florian HUBER , Hans-Peter JOSEL , Thomas MEIER , Michael SCHRAEML , Edgar VOSS
IPC: G01N33/543 , C07K16/44
Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
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公开(公告)号：US20220107309A1
公开(公告)日：2022-04-07
申请号：US17551716
申请日：2021-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael GERG , Klaus HIRZEL , Caroline HOJER , Erasmus HUBER , Hans-Peter JOSEL , Thomas MEIER , Michael SCHRAEML , Leopold VON PROFF
IPC: G01N33/543 , C07K16/44
Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
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公开(公告)号：US20240044804A9
公开(公告)日：2024-02-08
申请号：US17405742
申请日：2021-08-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter JOSEL , Herbert ANDRES , Michaela WINDFUHR , Oliver LARBOLETTE , Stefan QUINT
IPC: G01N21/76 , G01N33/543 , C07F15/00 , G01N21/66
CPC classification number: G01N21/76 , G01N33/5438 , C07F15/0033 , C07F15/0046 , G01N21/66 , G01N2458/30 , G01N27/308
Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
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公开(公告)号：US20220169664A1
公开(公告)日：2022-06-02
申请号：US17588884
申请日：2022-01-31
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter JOSEL , Tobias OELSCHLAEGEL , Giuseppe PRENCIPE , Luisa DE COLA , Elena LONGHI , Chien-Wei HSU
Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
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