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    Cell detection device and cell detection method
    1.
    发明授权
    Cell detection device and cell detection method 有权

    公开(公告)号：US10801007B2

    公开(公告)日：2020-10-13

    申请号：US16591670

    申请日：2019-10-03

    Applicant: SYSMEX CORPORATION

    Inventor： Seiichiro Tabata ,  Masatoshi Yanagida

    IPC: C12M1/34 ,  G01N15/14 ,  G01N15/10 ,  G01N1/40 ,  C12M1/00

    Abstract: A cell detection device and a cell detection method is provided with which it is possible to efficiently acquire images of cells to be measured. Cell detection device comprises flow cell through which a measurement specimen that contains particles is caused to flow, particle detector for detecting the particles in the measurement specimen supplied to flow cell, particle sorter for sorting particles that satisfy a detection condition and other particles on the basis of the result of detection performed by particle detector, specimen supply part for supplying, to flow cell, an image-capture specimen that includes detection-condition-satisfying particles that have been sorted by particle sorter, and particle-image-capture part for capturing images of the particles in the sorted image-capture specimen supplied to flow cell.

    Particle imaging apparatus and particle imaging method
    2.
    发明授权
    Particle imaging apparatus and particle imaging method 有权

    公开(公告)号：US10156510B2

    公开(公告)日：2018-12-18

    申请号：US15443865

    申请日：2017-02-27

    Applicant: Sysmex Corporation

    Inventor： Seiichiro Tabata ,  Masaki Ishisaka ,  Kenji Akama ,  Yoshinobu Miura ,  Masatoshi Yanagida

    IPC: G01N15/14 ,  G01N21/05 ,  G01N15/10

    Abstract: A particle imaging apparatus comprises a flow path comprising a first flow path section, a second flow path section connected downstream of the first flow path section, and a third flow path section that is branched from the first flow path section, a particle detection unit comprising a light source and a light detector, a particle sorting unit configured to adjust a flow direction of the particle, and a particle imaging unit configured to take an image of a particle that flows in the second flow path section. The flow path is structured such that a cross-sectional area of the second flow path section is greater than a cross-sectional area of the first flow path section. The first flow path section and the second flow path section are disposed so as to be linearly aligned.

    Cell selection method, cell detection method, cell selection apparatus, and cell detection apparatus
    4.
    发明授权
    Cell selection method, cell detection method, cell selection apparatus, and cell detection apparatus 有权

    公开(公告)号：US11060134B2

    公开(公告)日：2021-07-13

    申请号：US15363503

    申请日：2016-11-29

    Applicant: Sysmex Corporation

    Inventor： Yusuke Takahashi ,  Masatoshi Yanagida

    IPC: G01N33/00 ,  C12Q1/6841 ,  G01N21/64

    Abstract: Disclosed is a cell selection method including a sample preparation step of preparing a sample by performing staining of nucleic acid in each of cells by a first fluorescent dye; and hybridization with respect to an evaluation target region in DNA in each cell by an evaluation probe including a second fluorescent dye; a light receiving step of applying light to the sample and receiving fluorescence from the first fluorescent dye and fluorescence from the second fluorescent dye; and a selection step of selecting an analysis target cell on the basis of intensity of the fluorescence from the first fluorescent dye and intensity of the fluorescence from the second fluorescent dye, wherein the first fluorescent dye is a dye that emits fluorescence having a first wavelength, and the second fluorescent dye is a dye that emits fluorescence having a second wavelength different from the first wavelength.

    Cell detection device and cell detection method
    5.
    发明授权
    Cell detection device and cell detection method 有权

    公开(公告)号：US10513679B2

    公开(公告)日：2019-12-24

    申请号：US15159089

    申请日：2016-05-19

    Applicant: SYSMEX CORPORATION

    Inventor： Seiichiro Tabata ,  Masatoshi Yanagida

    IPC: C12M1/34 ,  G01N15/14 ,  G01N15/10 ,  C12M1/00 ,  G01N1/40

    Abstract: A cell detection device and a cell detection method is provided with which it is possible to efficiently acquire images of cells to be measured. Cell detection device comprises flow cell through which a measurement specimen that contains particles is caused to flow, particle detector for detecting the particles in the measurement specimen supplied to flow cell, particle sorter for sorting particles that satisfy a detection condition and other particles on the basis of the result of detection performed by particle detector, specimen supply part for supplying, to flow cell, an image-capture specimen that includes detection-condition-satisfying particles that have been sorted by particle sorter, and particle-image-capture part for capturing images of the particles in the sorted image-capture specimen supplied to flow cell.

    METHOD FOR MEASURING IMMUNOSTIMULATORY RESPONSE OF IMMUNE CELL, METHOD FOR DETERMINING ABILITY TO FORM IMMUNE SYNAPSE IN IMMUNE CELL, AND CELL ANALYZER
    6.
    发明申请
    METHOD FOR MEASURING IMMUNOSTIMULATORY RESPONSE OF IMMUNE CELL, METHOD FOR DETERMINING ABILITY TO FORM IMMUNE SYNAPSE IN IMMUNE CELL, AND CELL ANALYZER 审中-公开

    公开(公告)号：US20180292385A1

    公开(公告)日：2018-10-11

    申请号：US15949577

    申请日：2018-04-10

    Applicant: SYSMEX CORPORATION

    Inventor： Masatoshi Yanagida ,  Keiko Miwa ,  Yuma Oka

    IPC: G01N33/50 ,  G01N33/58 ,  G06T7/00

    Abstract: Disclosed is a method for measuring an immunostimulatory response of an immune cell, including (i) bringing a measurement target immune cell into contact with an immunostimulator, (ii) forming a contact surface with a substance different from the measurement target immune cell on the measurement target immune cell, (iii) bringing the measurement target immune cell into contact with a capturing body that binds to a surface antigen on the contact surface and is capable of generating an optical signal, (iv) detecting the optical signal generated from the capturing body, and (v) determining whether or not the measurement target immune cell from which the contact surface has been eliminated before detecting the optical signal has an immunostimulatory response, based on the detected optical signal.

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