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1.发明申请Oligonucleotides useful for detecting and analyzing nucleic acids of interest 审中-公开可用于检测和分析感兴趣的核酸的寡核苷酸公开(公告)号：US20070117144A1
公开(公告)日：2007-05-24
申请号：US11643615
申请日：2006-12-21
申请人： Sakari Kauppinen , Carsten Alsbo , Peter Nielsen , Daniel Jeffares , Tobias Mourier , Soren Mork , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing
发明人： Sakari Kauppinen , Carsten Alsbo , Peter Nielsen , Daniel Jeffares , Tobias Mourier , Soren Mork , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing
IPC分类号： C12Q1/68
摘要： The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.
摘要翻译： 本发明的特征在于改进的核酸和用于mRNA表达谱的方法，特异性mRNA剪接变体的鉴定和分析，以及检测特定外显子或其他剪接变体的突变，缺失或重复，例如与疾病如癌症相关的改变， 在核酸样品中，例如生物样品或患者样品。
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2.发明申请OLIGONUCLEOTIDES USEFUL FOR DETECTING AND ANALYZING NUCLEIC ACIDS OF INTEREST 有权用于检测和分析有益的核酸的有效的寡核苷酸公开(公告)号：US20120157333A1
公开(公告)日：2012-06-21
申请号：US13295615
申请日：2011-11-14
申请人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
发明人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
摘要： The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.
摘要翻译： 本发明的特征在于改进的核酸和用于mRNA表达谱的方法，特异性mRNA剪接变体的鉴定和分析，以及检测特定外显子或其他剪接变体的突变，缺失或重复，例如与疾病如癌症相关的改变， 在核酸样品中，例如生物样品或患者样品。
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3.发明授权Oligonucleotides useful for detecting and analyzing nucleic acids of interest 有权可用于检测和分析感兴趣的核酸的寡核苷酸公开(公告)号：US09464106B2
公开(公告)日：2016-10-11
申请号：US13295615
申请日：2011-11-14
申请人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
发明人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
摘要： The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.
摘要翻译： 本发明的特征在于改进的核酸和用于mRNA表达谱的方法，特异性mRNA剪接变体的鉴定和分析，以及检测特定外显子或其他剪接变体的突变，缺失或重复，例如与疾病如癌症相关的改变， 在核酸样品中，例如生物样品或患者样品。
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公开(公告)号：US20060147924A1
公开(公告)日：2006-07-06
申请号：US10527211
申请日：2003-09-11
申请人： Neils Ramsing , Alex Nielsen , Elexei Koshkin , Niels Tolstrup , Henrik Pfundheller , Christian Lomholt
发明人： Neils Ramsing , Alex Nielsen , Elexei Koshkin , Niels Tolstrup , Henrik Pfundheller , Christian Lomholt
CPC分类号： C12Q1/6837 , C07H19/00 , C07H21/00 , C12Q2525/204 , C12Q2525/117
摘要： The present invention relates to a population of nucleic acids, said population comprising a first population of nucleic acids of the same length, said length being in the range of 5-15 nucleotides or units, said first population representing at least 1% of the possible different nucleic acid sequences for nucleic acids of said length, at least one nucleic acid in the first population being an LNA (Locked Nucleoside Analogues) oligomer. The population of oligonucleotides is preferably bonded to a solid support. The pluralities of nucleic acids are particularly useful in methods relating to the capture of target nucleic acids, or as probes, e.g. PCR probes. The invention also features LNA oligomers wherein the LNA units have SBC (Selective Binding Complementary) nucleobases.
摘要翻译： 本发明涉及核酸群体，所述群体包含相同长度的第一核酸群，所述长度在5-15个核苷酸或单位的范围内，所述第一群体代表可能的至少1％ 所述长度的核酸的不同核酸序列，第一群体中的至少一个核酸是LNA（锁定核苷类似物）寡聚体。 寡核苷酸群体优选与固体支持物结合。 多种核酸特别可用于与捕获靶核酸或作为探针的方法相关的方法。 PCR探针。 本发明还具有其中LNA单元具有SBC（选择性结合互补）核碱基的LNA寡聚体。
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5.发明申请Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same 审中-公开用于分析核酸混合物的探针，文库和试剂盒及其构建方法公开(公告)号：US20060166238A1
公开(公告)日：2006-07-27
申请号：US11314868
申请日：2005-12-21
申请人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
发明人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
CPC分类号： C12Q1/6816 , C12Q1/6851 , G16B25/00 , G16B35/00 , G16C20/60 , C12Q2525/204 , C12Q2525/179 , C12Q2525/113 , C12Q2537/143 , C12Q2561/113
摘要： The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantifying components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid.
摘要翻译： 本发明涉及核酸探针，核酸探针文库和用于检测，分类或定量核酸复合物如转录组的组分的试剂盒及其使用方法。 本发明还涉及鉴定在探针文库中有用的核酸探针的方法以及鉴定用于检测给定核酸的手段的方法。
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6.发明申请Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same 审中-公开用于分析核酸混合物的探针，文库和试剂盒及其构建方法公开(公告)号：US20050089889A1
公开(公告)日：2005-04-28
申请号：US10871471
申请日：2004-06-18
申请人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
发明人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
CPC分类号： C12Q1/6876 , C12N15/1065 , C12Q1/6816 , C12Q2600/158 , G16B25/00 , C12Q2531/113 , C12Q2527/101 , C12Q2525/179
摘要： The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantitating components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid.
摘要翻译： 本发明涉及核酸探针，核酸探针文库和用于检测，分类或定量核酸复合物如转录组的组分的试剂盒及其使用方法。 本发明还涉及鉴定在探针文库中有用的核酸探针的方法以及鉴定用于检测给定核酸的手段的方法。
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