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公开(公告)号：US09902758B2
公开(公告)日：2018-02-27
申请号：US15137942
申请日：2016-04-25
Applicant: Samsung Electronics Co., Ltd.
Inventor： Dongkyu Shin , Jung Min Kim , Kyoung Hu Lee , Jae Il Lee , Jung Wook Lee
CPC classification number: C07K14/4746 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K2319/00
Abstract: A three-helix bundle protein, a polynucleotide encoding the three-helix bundle protein, a method of preparing the three-helix bundle protein, and a method of treating a cancer using the three-helix bundle protein.
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2.发明授权公开(公告)号：US09573985B2
公开(公告)日：2017-02-21
申请号：US14615146
申请日：2015-02-05
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jung-Hoon Lee , Eunji Kang , Jung Min Kim , Jung-Min Lee , Jae Il Lee
CPC classification number: C07K14/4738 , A61K38/00
Abstract: A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition comprising the p16 protein variant; a method for preventing and/or treating cancer comprising administering the p16 protein variant to a subject; and use of the p16 protein variant in the prophylaxis and/or therapy of cancer.
Abstract translation: p16蛋白变体; 编码p16蛋白质变体的多核苷酸; 制备p16蛋白质变体的方法; 包含p16蛋白质变体的药物组合物; 一种用于预防和/或治疗癌症的方法，其包括将p16蛋白质变体施用于受试者; 以及在预防和/或治疗癌症中使用p16蛋白质变体。
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3.发明申请FUSION PROTEIN COMPRISING TARGETING MOIETY, CLEAVAGE SITE, AND CELL MEMBRANE PENETRATING DOMAIN, AND USE THEREOF 有权融合蛋白质包含靶向区域，CLEAVAGE SITE和细胞膜穿透域及其使用公开(公告)号：US20160008480A1
公开(公告)日：2016-01-14
申请号：US14794542
申请日：2015-07-08
Applicant: SAMSUNG ELECTRONICS CO., LTD.
Inventor： Jae Il Lee , Soshin Ahn , Jung Min Kim , Jungmin Lee , Jung-Hoon Lee
CPC classification number: C07K16/30 , A61K38/00 , A61K47/6851 , C07K14/47 , C07K16/2863 , C07K2318/20 , C07K2319/10 , C07K2319/33 , C07K2319/50
Abstract: A fusion protein including a targeting moiety, a cleavage site, and a cell membrane penetrating domain, a conjugate including the fusion protein and a bioactive molecule, and methods employing the fusion protein and the conjugate are provided.
Abstract translation: 提供了包含靶向部分，切割位点和细胞膜穿透结构域的融合蛋白，包含融合蛋白和生物活性分子的缀合物，以及使用融合蛋白和缀合物的方法。
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公开(公告)号：US20150335669A1
公开(公告)日：2015-11-26
申请号：US14717753
申请日：2015-05-20
Applicant: Samsung Electronics Co., Ltd.
Inventor： Su Young Chae , Sunghyun Kim , Sang Ok Song , Jae Il Lee
IPC: A61K31/704 , C07K16/40 , A61K47/48
CPC classification number: A61K31/704 , A61K47/60 , A61K47/6809 , A61K47/6871 , C07K16/2863 , C07K2317/14 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92 , C07K2317/94
Abstract: Provided is a chemically modified targeting protein, a pharmaceutical composition including the chemically modified targeting protein, a conjugate including the chemically modified targeting protein and a drug, and methods for preparing the same.
Abstract translation: 提供了化学修饰的靶向蛋白质，包含化学修饰的靶向蛋白质的药物组合物，包含化学修饰的靶向蛋白质和药物的缀合物及其制备方法。
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公开(公告)号：US09879081B2
公开(公告)日：2018-01-30
申请号：US14315068
申请日：2014-06-25
Applicant: Samsung Electronics Co., Ltd.
Inventor： Hye Young Suh , Jae Il Lee , Su-Jeong Hwang
CPC classification number: C07K16/22 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73
Abstract: A protein complex comprising a first polypeptide comprising a first antigen-binding region; a second polypeptide comprising a second antigen-binding region; anda linker connecting the first polypeptide and the second polypeptide, wherein the first antigen-binding region is a single stranded polypeptide comprising a first light chain antigen-binding region and a first heavy chain antigen-binding region, the second antigen-binding region is a single stranded polypeptide comprising a second light chain antigen-binding region and a second heavy chain antigen-binding region, and the linker connects the C-terminal of the first polypeptide and the N-terminal of the second polypeptide, and comprises a tag including a cleavable amino acid sequence at one terminal or both terminals of the linker; as well as a bispecific antibody derived from the protein complex, and related compositions and methods.
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Patent Agency Ranking
公开(公告)号：US20160311878A1
公开(公告)日：2016-10-27
申请号：US15137942
申请日：2016-04-25
Applicant: Samsung Electronics Co., Ltd.
Inventor： Dongkyu Shin , Jung Min Kim , Kyoung Hu Lee , Jae Il Lee , Jung Wook Lee
IPC: C07K14/47
CPC classification number: C07K14/4746 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K2319/00
Abstract: A three-helix bundle protein, a polynucleotide encoding the three-helix bundle protein, a method of preparing the three-helix bundle protein, and a method of treating a cancer using the three-helix bundle protein.
Abstract translation: 三螺旋束蛋白，编码三螺旋束蛋白的多核苷酸，制备三螺旋束蛋白的方法，以及使用三螺旋束蛋白治疗癌症的方法。
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7.发明申请公开(公告)号：US20150218240A1
公开(公告)日：2015-08-06
申请号：US14615146
申请日：2015-02-05
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jung-Hoon Lee , Eunji Kang , Jung Min Kim , Jung-Min Lee , Jae Il Lee
CPC classification number: C07K14/4738 , A61K38/00
Abstract: A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition comprising the p16 protein variant; a method for preventing and/or treating cancer comprising administering the p16 protein variant to a subject; and use of the p16 protein variant in the prophylaxis and/or therapy of cancer.
Abstract translation: p16蛋白变体; 编码p16蛋白质变体的多核苷酸; 制备p16蛋白质变体的方法; 包含p16蛋白质变体的药物组合物; 一种用于预防和/或治疗癌症的方法，其包括将p16蛋白质变体施用于受试者; 以及在预防和/或治疗癌症中使用p16蛋白质变体。
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公开(公告)号：US20150094271A1
公开(公告)日：2015-04-02
申请号：US14502088
申请日：2014-09-30
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jung-Hoon Lee , Eunji Kang , Hye Yoon Kang , Dongkyu Shin , Jae Il Lee , Jieun Han , Jung Min Lee
IPC: C07K14/47 , C12N7/00 , C07K14/005
CPC classification number: C12N7/00 , A61K38/00 , C07K14/4746 , C07K2319/10 , C07K2319/73
Abstract: A leucine zipper variant, a polynucleotide encoding the leucine zipper variant, a method of preparing a leucine zipper variant, a method of inhibiting HDM2- and/or HDMX using the leucine zipper variant, and a method of the prevention and/or treatment of cancer using the leucine zipper variant.
Abstract translation: 亮氨酸拉链变体，编码亮氨酸拉链变体的多核苷酸，制备亮氨酸拉链变体的方法，使用亮氨酸拉链变体抑制HDM2-和/或HDMX的方法，以及预防和/或治疗癌症的方法 使用亮氨酸拉链变体。
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公开(公告)号：US10159690B2
公开(公告)日：2018-12-25
申请号：US14717753
申请日：2015-05-20
Applicant: Samsung Electronics Co., Ltd.
Inventor： Su Young Chae , Sunghyun Kim , Sang Ok Song , Jae Il Lee
IPC: A61K47/60 , A61K47/68 , C07K16/28 , A61K31/704
Abstract: Provided is a chemically modified targeting protein, a pharmaceutical composition including the chemically modified targeting protein, a conjugate including the chemically modified targeting protein and a drug, and methods for preparing the same.
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10.发明授权公开(公告)号：US09747170B2
公开(公告)日：2017-08-29
申请号：US14208600
申请日：2014-03-13
Applicant: Samsung Electronics Co., Ltd.
Inventor： Jae Il Lee
CPC classification number: G06F11/1458 , G06F3/0613 , G06F3/065 , G06F3/0679 , G06F12/0246 , G06F2212/1016 , G06F2212/7203 , G06F2212/7208
Abstract: In one example embodiment of the inventive concepts, an adaptive data backup method performed in a memory system including a non-volatile multi-level cell memory device includes receiving a write command from a host and determining a backup data size which is a size of data to be backed up among data requested to be written in the write command. The adaptive data backup method further includes selecting a backup type among at least two different backup types, based on the backup data size and backing up the data according to the selected backup type.
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