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1.发明授权Enhancement of bone morphogenic protein (BMP) retention with BMP binding peptide (BBP) 有权用BMP结合肽（BBP）增强骨形态发生蛋白（BMP）保留公开(公告)号：US09072709B2
公开(公告)日：2015-07-07
申请号：US13379436
申请日：2010-06-23
申请人： Samuel S. Murray , Elsa Murray , Jeffrey Wang , Keyvan Behnam
发明人： Samuel S. Murray , Elsa Murray , Jeffrey Wang , Keyvan Behnam
CPC分类号： A61K38/12 , A61K38/08 , A61K38/10 , A61K38/1841 , A61K38/1875 , A61K2300/00
摘要： The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates of fusion success, it is associated with increased operative time and blood loss, along with a significant degree of donor-site morbidity. Additionally, in certain settings such as revision cases, multilevel constructs, or in patients with medical comorbidities, autogenous bone graft may exist in limited quantity and quality. This significant need for a suitable alternative to autogenous bone graft has stimulated great interest in the exploration of bone graft substitutes and extenders.
摘要翻译： 在美国每年进行的150万次骨移植手术中，使用自体骨移植是目前的黄金标准。 尽管这种做法导致融合率高，但与手术时间和失血量相关，伴随着供体位点发病率的显着程度。 另外，在某些情况下，例如修订案例，多层次结构，或在具有医学合并症的患者中，自体骨移植可能存在数量有限和质量上的问题。 对于自体骨移植物的合适替代物的这种显着需要刺激了对骨移植物替代物和增量剂的探索的极大兴趣。
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公开(公告)号：US20120184490A1
公开(公告)日：2012-07-19
申请号：US13379436
申请日：2010-06-23
申请人： Samuel S. Murray , Elsa Murray , Jeffrey Wang , Keyvan Behnam
发明人： Samuel S. Murray , Elsa Murray , Jeffrey Wang , Keyvan Behnam
CPC分类号： A61K38/12 , A61K38/08 , A61K38/10 , A61K38/1841 , A61K38/1875 , A61K2300/00
摘要： The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates of fusion success, it is associated with increased operative time and blood loss, along with a significant degree of donor-site morbidity. Additionally, in certain settings such as revision cases, multilevel constructs, or in patients with medical comorbidities, autogenous bone graft may exist in limited quantity and quality. This significant need for a suitable alternative to autogenous bone graft has stimulated great interest in the exploration of bone graft substitutes and extenders.
摘要翻译： 在美国每年进行的150万次骨移植手术中，使用自体骨移植是目前的黄金标准。 尽管这种做法导致融合率高，但与手术时间和失血量相关，伴随着供体位点发病率的显着程度。 另外，在某些情况下，例如修订案例，多层次结构，或在具有医学合并症的患者中，自体骨移植可能存在数量有限和质量上的问题。 对于自体骨移植物的合适替代物的这种显着需要刺激了对骨移植物替代物和增量剂的探索的极大兴趣。
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公开(公告)号：US08975231B2
公开(公告)日：2015-03-10
申请号：US13486498
申请日：2012-06-01
CPC分类号： A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
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公开(公告)号：US20130095139A1
公开(公告)日：2013-04-18
申请号：US13486498
申请日：2012-06-01
IPC分类号： C07K7/08
CPC分类号： A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
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公开(公告)号：US20080241108A1
公开(公告)日：2008-10-02
申请号：US10587313
申请日：2005-01-28
IPC分类号： A61K35/12 , C07K7/08 , A61K38/10 , G01N33/53 , C12N1/21 , A61P19/00 , C07K16/00 , C12Q1/68 , C07H21/04 , G01N33/68
CPC分类号： A61K38/1875 , A61K35/32 , A61K38/10 , A61K38/1709 , A61K38/1841 , C07K7/08 , C07K14/47 , C07K14/51 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the over-all osteogenic activity of rgBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
摘要翻译： 称为BMP结合肽（BBP）的环化肽是一种合适的肽，其能够强烈地结合rhBMP-2。 BBP增加rgBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。 包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。
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公开(公告)号：US08193312B2
公开(公告)日：2012-06-05
申请号：US11985745
申请日：2007-11-16
IPC分类号： C07K4/12 , C07K5/12 , C07K14/51 , C07K14/495 , A61K38/10 , A61K38/12 , A61K38/18 , A61F2/26 , A61P19/00
CPC分类号： A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
摘要翻译： 称为BMP结合肽（BBP）的环化肽是与内生形式的BBP一样强烈地结合rhBMP-2的合成肽，并且物种之间的序列保守性导致各种有用的BBP组合物。 BBP增加rhBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。 包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。
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公开(公告)号：US20100183719A1
公开(公告)日：2010-07-22
申请号：US12448497
申请日：2007-12-26
CPC分类号： A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
摘要： The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
摘要翻译： 本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。 另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。
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公开(公告)号：US20080268012A1
公开(公告)日：2008-10-30
申请号：US11791940
申请日：2005-11-29
IPC分类号： A61K35/32 , A61K38/00 , A61P19/00 , A61K38/29 , A61K38/30 , A61K38/18 , A61K33/06 , A61K38/23 , A61K33/16 , A61F2/00 , A61F2/02
CPC分类号： A61K35/32 , A61K38/1841 , A61K38/1875 , A61K38/23 , A61K38/29 , A61K38/30 , A61K45/06 , A61K2300/00 , A61K33/06
摘要： Demineralized bone matric (DBM) and native bone morphogenetic protein (nBMP) are complex mixtures of non-collagenous bone proteins. These mixtures contain many of the BMPs that are available as recombinant molecules. Information regarding the presence in these materials of molecules that may affect the availability and activity of the BMPs is very limited. A chemical extraction of DBM, such as using alkali-urea produces a water soluble extractate which inhibits the osteogenic activity of DBM. Noggin, an extracellular BMP ligand antagonist is found in the water soluble extractate from DBM. Differential chemical extraction is a useful means of removing non-osteogenic, or osteogenic inhibitory molecules from DBM and nBMP.
摘要翻译： 脱矿骨质（DBM）和天然骨形态发生蛋白（nBMP）是非胶原性骨蛋白的复杂混合物。 这些混合物含有许多可用作重组分子的BMP。 关于可能影响BMP的可用性和活性的这些分子材料的存在的信息非常有限。 DBM的化学提取，例如使用碱 - 尿素，产生一种抑制DBM成骨活性的水溶性提取物。 在DBM的水溶性提取物中发现Noggin是细胞外BMP配体拮抗剂。 差异化学提取是从DBM和nBMP中去除非成骨或成骨抑制分子的有用手段。
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公开(公告)号：US20130095075A1
公开(公告)日：2013-04-18
申请号：US13481648
申请日：2012-05-25
CPC分类号： A61K38/1875 , A61K35/32 , A61K38/10 , A61K38/1709 , A61K38/1841 , C07K7/08 , C07K14/47 , C07K14/51 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
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公开(公告)号：US08188219B2
公开(公告)日：2012-05-29
申请号：US10587313
申请日：2005-01-28
IPC分类号： C07K4/12 , C07K5/12 , C07K14/51 , C07K14/495 , A61K38/10 , A61K38/12 , A61K38/18 , A61F2/26 , A61P19/00 , C12N5/07
CPC分类号： A61K38/1875 , A61K35/32 , A61K38/10 , A61K38/1709 , A61K38/1841 , C07K7/08 , C07K14/47 , C07K14/51 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the over-all osteogenic activity of rgBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
摘要翻译： 称为BMP结合肽（BBP）的环化肽是一种合适的肽，其能够强烈地结合rhBMP-2。 BBP增加rgBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。 包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。
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