5-fluorouracil derivatives
    5.
    发明授权
    5-fluorouracil derivatives 失效
    5-氟尿嘧啶衍生物

    公开(公告)号:US5047521A

    公开(公告)日:1991-09-10

    申请号:US150407

    申请日:1988-02-09

    摘要: This invention relates to a novel 5-fluorouracil derivative represented by the formula ##STR1## wherein R.sup.y is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group ##STR2## wherein R.sup.1 and R.sup.2 are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group R.sup.x OCO-- on the phenyl ring, or a group --(A).sub.n B, R.sup.x being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from N, O and S and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that R.sup.1 and R.sup.2 are not hydrogen atoms or specific acyl groups at the same time; to a process for preparing the same; and to an anticancer composition comprising the same as an effective ingredient.

    摘要翻译: PCT No.PCT / JP87 / 00275 Sec。 371日期1988年2月9日 102(e)1988年2月9日PCT PCT公开1987年4月30日PCT公布。 公开号WO87 / 06582 日本公开日:1987年11月5日。本发明涉及由式(1)表示的新型5-氟尿嘧啶衍生物,其中R y为氢原子或特定酰基,Z为苯基 - 低级烷氧基 - 低级烷基 任选被噻吩基环上的卤素原子取代的噻吩基 - 低级烷基,或其中R 1和R 2各自为氢原子,特定酰基,具有基团R xOCO-的苯基 - 低级烷基基团 环,或基团 - (A)nB,Rx是特定的有机基团,A是低级亚烷基,n是0或1,B是具有1〜4个杂原子的5或6元不饱和杂环基, 选自N,O和S且任选具有苯环的原子,萘环或与其缩合的吡啶环,条件是R1和R2不同时为氢原子或特定酰基; 一个制备它的过程; 以及包含其作为有效成分的抗癌组合物。