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公开(公告)号:US20100256774A1
公开(公告)日:2010-10-07
申请号:US12744810
申请日:2008-12-12
申请人: Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
发明人: Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
IPC分类号: A61F2/28
CPC分类号: A61L27/3691 , A61F2/28 , A61F2/4644 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61F2310/00359 , A61F2310/00371 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L27/46 , A61L2400/06 , A61L2430/02 , A61L2430/40 , C08L89/06
摘要: A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
摘要翻译: 组合物包括骨和胶原,其中胶原蛋白已被酸处理,并通过脱水热处理或通过交联剂(例如柠檬酸衍生物)在至少约40MPa的压缩力下进行交联。
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公开(公告)号:US09168327B2
公开(公告)日:2015-10-27
申请号:US12744810
申请日:2008-12-12
申请人: Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
发明人: Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
CPC分类号: A61L27/3691 , A61F2/28 , A61F2/4644 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61F2310/00359 , A61F2310/00371 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L27/46 , A61L2400/06 , A61L2430/02 , A61L2430/40 , C08L89/06
摘要: A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
摘要翻译: 组合物包括骨和胶原,其中胶原蛋白已被酸处理,并通过脱水热处理或通过交联剂(例如柠檬酸衍生物)在至少约40MPa的压缩力下进行交联。
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3.
公开(公告)号:US20080195202A1
公开(公告)日:2008-08-14
申请号:US11673972
申请日:2007-02-12
IPC分类号: A61F2/02
CPC分类号: A61L27/54 , A61L15/325 , A61L27/24 , A61L27/34 , A61L2300/00
摘要: Purifying human derived collagen from human tissue includes treating harvested human tissue with an enzyme to form a collagen product, deactivating the enzyme with a non-alkaline enzyme deactivation solution, and collecting the collagen product resulting from the enzyme treatment, where the collected collagen product includes a preserved amount of its natural collagen constituents. Various medical implants can be formed using the isolated, enzymatically-treated human derived collagen having an amount of its natural collagen constituents preserved, and may include implantable sponges, patches, tubes, structural supports and coatings, and which may be used for repair, barrier, support and/or stabilization purposes.
摘要翻译: 从人体组织中纯化人源胶原蛋白包括用酶处理收获的人体组织以形成胶原产物,用非碱性酶失活溶液使酶失活,以及收集由酶处理产生的胶原产物,其中所收集的胶原产品包括 保留量的天然胶原成分。 可以使用分离的,经酶处理的人源胶原蛋白形成各种医学植入物,其具有保存的天然胶原蛋白成分的量,并且可以包括可植入的海绵,贴剂,管,结构载体和涂层,并且其可用于修复,屏障 ,支持和/或稳定目的。
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公开(公告)号:US20120276150A1
公开(公告)日:2012-11-01
申请号:US13096570
申请日:2011-04-28
CPC分类号: A61K38/39 , A61K38/18 , A61L27/24 , A61L27/32 , A61L27/3662 , A61L27/3687 , A61L27/56 , A61L2300/414 , A61L2430/34
摘要: Compositions and methods for treating and healing injured soft tissues such as tendons and ligaments are provided. The composition may be a wrap comprising human collagen in the form of a sheet. The human collagen has been processed so that is retains proteins that are associated with it in its natural state. The sheet may optionally be coated on one or more sides with one or more of additional human collagen, therapeutic agents, additional soft tissue growth factors or hydroxyapatite.
摘要翻译: 提供了治疗和愈合损伤的软组织如腱和韧带的组合物和方法。 组合物可以是包含片状形式的人胶原蛋白的包装物。 人类胶原蛋白已被处理,因此保留与其天然状态相关的蛋白质。 该片材可以任选地在一个或多个侧面上涂覆一种或多种另外的人胶原蛋白,治疗剂,另外的软组织生长因子或羟基磷灰石。
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公开(公告)号:US09017711B2
公开(公告)日:2015-04-28
申请号:US13096570
申请日:2011-04-28
IPC分类号: A61F2/00 , A61K9/70 , A61K35/32 , A61K38/39 , A61K38/18 , A61L27/24 , A61L27/32 , A61L27/36 , A61L27/56
CPC分类号: A61K38/39 , A61K38/18 , A61L27/24 , A61L27/32 , A61L27/3662 , A61L27/3687 , A61L27/56 , A61L2300/414 , A61L2430/34
摘要: Compositions and methods for treating and healing injured soft tissues such as tendons and ligaments are provided. The composition may be a wrap comprising human collagen in the form of a sheet. The human collagen has been processed so that is retains proteins that are associated with it in its natural state. The sheet may optionally be coated on one or more sides with one or more of additional human collagen, therapeutic agents, additional soft tissue growth factors or hydroxyapatite.
摘要翻译: 提供了治疗和愈合损伤的软组织如腱和韧带的组合物和方法。 组合物可以是包含片状形式的人胶原蛋白的包装物。 人类胶原蛋白已被处理,因此保留与其天然状态相关的蛋白质。 该片材可以任选地在一个或多个侧面上涂覆一种或多种另外的人胶原蛋白,治疗剂,另外的软组织生长因子或羟基磷灰石。
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6.
公开(公告)号:US09056151B2
公开(公告)日:2015-06-16
申请号:US11673972
申请日:2007-02-12
CPC分类号: A61L27/54 , A61L15/325 , A61L27/24 , A61L27/34 , A61L2300/00
摘要: Purifying human derived collagen from human tissue includes treating harvested human tissue with an enzyme to form a collagen product, deactivating the enzyme with a non-alkaline enzyme deactivation solution, and collecting the collagen product resulting from the enzyme treatment, where the collected collagen product includes a preserved amount of its natural collagen constituents. Various medical implants can be formed using the isolated, enzymatically-treated human derived collagen having an amount of its natural collagen constituents preserved, and may include implantable sponges, patches, tubes, structural supports and coatings, and which may be used for repair, barrier, support and/or stabilization purposes.
摘要翻译: 从人体组织中纯化人源胶原蛋白包括用酶处理收获的人体组织以形成胶原产物,用非碱性酶失活溶液使酶失活,以及收集由酶处理产生的胶原产物,其中所收集的胶原产品包括 保留量的天然胶原成分。 可以使用分离的,经酶处理的人源胶原蛋白形成各种医学植入物,其具有保存的天然胶原成分的量,并且可以包括可植入的海绵,贴剂,管,结构载体和涂层,并且其可用于修复,屏障 ,支持和/或稳定目的。
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公开(公告)号:US20080260794A1
公开(公告)日:2008-10-23
申请号:US12030188
申请日:2008-02-12
CPC分类号: A61K38/39 , A61L15/32 , A61L15/40 , A61L27/24 , A61L27/34 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L27/54 , A61L2300/414
摘要: Medical implants and methods for forming a medical implant blends a dispersion of human collagen fibers and/or threads and optionally a volume between about 2 to about 15% of an alcohol and forms medical implants by removing a liquid component of the collagen dispersion. Medical implants formed include collagen films, coatings, threads, patches, tubes, plugs, scaffolds, injectable collagen, and collagen for in vitro applications.
摘要翻译: 用于形成医疗植入物的医学植入物和方法将人胶原纤维和/或丝线的分散体和任选的约2至约15%的醇之间的体积混合并通过除去胶原分散体的液体组分形成医疗植入物。 形成的医疗植入物包括胶原膜,涂层,线,贴片,管,塞子,支架,可注射的胶原和用于体外应用的胶原蛋白。
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公开(公告)号:US4622089A
公开(公告)日:1986-11-11
申请号:US726170
申请日:1985-04-22
申请人: Nels J. Lauritzen
发明人: Nels J. Lauritzen
CPC分类号: A61F13/0276 , A61F13/0203 , Y10S602/90 , Y10T156/1052 , Y10T156/1054
摘要: Adhesive bandages comprising a blister pad and adjacent adhesive-coated areas are prepared from heat-fusible bandage materials, preferably a nonwoven batt material, by applying the pad material to a base material and heat-welding around the perimeter of the pad to totally enclose the interior thereof. The portions of the base material extending from the pad area are compacted under heat and pressure to provide a surface suitable for a coating with adhesive. A medicated gel or other therapeutic material may be included within the confines of the pad area to provide a medicated blister bandage.
摘要翻译: 包括泡罩垫和相邻粘合剂涂覆区域的粘合绷带由热熔绷带材料(优选非织造棉絮材料)制备,通过将垫材料施加到基材上并围绕垫的周边进行热焊接,以完全包围 内部。 从焊盘区域延伸的基材的部分在热和压力下压实,以提供适于用粘合剂涂布的表面。 药膏凝胶或其他治疗材料可以包括在垫区域的范围内以提供药物吸塑绷带。
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公开(公告)号:US20090312524A1
公开(公告)日:2009-12-17
申请号:US10580904
申请日:2004-11-29
申请人: Nels J. Lauritzen
发明人: Nels J. Lauritzen
CPC分类号: A61K38/17
摘要: In various embodiments, a collagen product is provided that is derived from an animal, the collagen product comprises precipitated collagen that is substantially pure. In various embodiments, the collagen is obtained from a marine animal and does not contain prions or viruses. In various embodiments, the collagen can be made or incorporated into collagen films, collagen membranes, cosmetic collagen masks, collagen sponges, gelatin, hemostasis sponges, lyophilized foams, collagen injections, artificial skins and dura, bones, cartilage, screws, shafts, stems, or tube guides.
摘要翻译: 在各种实施方案中,提供衍生自动物的胶原产品,所述胶原产品包含基本上纯的沉淀胶原蛋白。 在各种实施方案中,胶原从海洋动物获得并且不含有朊病毒或病毒。 在各种实施方案中,可以将胶原蛋白制成或并入胶原膜,胶原膜,化妆胶原面具,胶原海绵,明胶,止血海绵,冻干泡沫,胶原注射,人造皮肤和硬脑膜,骨骼,软骨,螺钉,轴,茎 ,或导管。
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公开(公告)号:US07074425B2
公开(公告)日:2006-07-11
申请号:US10255451
申请日:2002-09-26
CPC分类号: A61K38/1875 , A61K31/65 , A61K31/7048 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2400/04 , A61K2300/00 , C08L71/02
摘要: The present invention provides methods and compositions involving resorbable hemostatic agents that have the essential absence of microfibrillar collagen. Resorbable hemostatic agents of the present invention comprise polyethylene glycol, which controls bleeding in tissue and does not delay or interfere with healing. The resorbable hemostatic agents of the present invention are biodegradable and biocompatible agents that effectively control bleeding in bone and other tissue without interfering with the subsequent healing of the tissue.
摘要翻译: 本发明提供了涉及可再吸收的止血剂的方法和组合物,其具有基本上不存在微原纤维胶原蛋白。 本发明的可再吸收的止血剂包括聚乙二醇,其控制组织中的出血并且不延迟或干扰愈合。 本发明的可再吸收的止血剂是可有效控制骨和其它组织中的出血的生物可降解和生物相容性试剂,而不会干扰组织随后的愈合。
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