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公开(公告)号：US4962030A
公开(公告)日：1990-10-09
申请号：US126005
申请日：1987-11-27
申请人： Shuji Kawai , Kazushi Oshino , Hiromi Okoshi , Hajime Mori , Katsuya Ozaki , Shitsuw Shikata , Susumu Ito , Kikuhiko Okamoto
发明人： Shuji Kawai , Kazushi Oshino , Hiromi Okoshi , Hajime Mori , Katsuya Ozaki , Shitsuw Shikata , Susumu Ito , Kikuhiko Okamoto
CPC分类号： C12R1/07 , C12N9/2437 , C12Y302/01004 , Y10S435/832
摘要： Alkaline cellulases having an optimum pH in an alkaline range and being stable over a broad pH range are produced by microorganisms which belong to the genus Bacillus and grow in a neutral medium.These alkaline cellulases are rarely inhibited by ingredients ordinarily incorporated in detergents such as surface active agents, proteinases and chelating agents, so that they can be conveniently used in detergent compositions.
摘要翻译： 在碱性范围内具有最佳pH并且在宽pH范围内稳定的碱性纤维素酶由属于芽孢杆菌属并在中性培养基中生长的微生物产生。 这些碱性纤维素酶很少被通常掺入洗涤剂如表面活性剂，蛋白酶和螯合剂中的成分抑制，因此它们可以方便地用于洗涤剂组合物中。
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2.发明授权
公开(公告)号：US4943532A
公开(公告)日：1990-07-24
申请号：US126739
申请日：1987-11-30
申请人： Shuji Kawai , Kazushi Oshino , Hiromi Okoshi , Hajime Mori , Katsutoshi Ara , Susumu Ito , Kikuhiko Okamoto
发明人： Shuji Kawai , Kazushi Oshino , Hiromi Okoshi , Hajime Mori , Katsutoshi Ara , Susumu Ito , Kikuhiko Okamoto
IPC分类号： C12N9/42
CPC分类号： C12R1/07 , C12N9/2437 , C12Y302/01004 , Y10S435/832
摘要： Novel alkali-resistant cellulases which have an optimum pH at a neutral region and have a high relative activity in an alkaline region are produced by microorganisms belonging to the genus Bacillus and growing in neutral medium.The cellulases suffer little inhibition by means of detergent ingredients such as surface active agents, proteinases and chelating agents. Therefore, they can be conveniently used as one of ingredients for detergent compositions.
摘要翻译： 在中性区域具有最佳pH并且在碱性区域中具有高相对活性的新型耐碱性纤维素酶由属于芽孢杆菌属的微生物产生并在中性培养基中生长。 纤维素酶几乎不受洗涤剂成分如表面活性剂，蛋白酶和螯合剂的抑制。 因此，它们可以方便地用作洗涤剂组合物的成分之一。
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3.发明授权DNA fragments containing alkaline cellulase gene, recombinant plasmids with said DNA fragments inserted therein, and recombinant microorganisms 失效含有碱性纤维素酶基因的DNA片段，插入有所述DNA片段的重组质粒和重组微生物
公开(公告)号：US4904599A
公开(公告)日：1990-02-27
申请号：US109510
申请日：1987-10-19
申请人： Katsuya Ozaki , Kazushi Oshino , Kenzo Koike , Susumu Ito , Kikuhiko Okamoto
发明人： Katsuya Ozaki , Kazushi Oshino , Kenzo Koike , Susumu Ito , Kikuhiko Okamoto
CPC分类号： C12N9/2437 , C12Y302/01004
摘要： DNA frangments containing an alkaline cellulase K gene, which comprise about 4.0, about 2.4 and about 1.9 kilo base pairs, respectively, each having a specific restruction map, recombinant plasmids containing any of these DNA fragments, and recombinant microorganisms harboring any of said plasmids.The alkaline cellulase K gene is derived from a bacterial strain which belongs to the genus Bacillus and is alkalophilic, that is, capable of revealing an optimum growth in an alkaline pH region.
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公开(公告)号：US08470302B2
公开(公告)日：2013-06-25
申请号：US12359385
申请日：2009-01-26
IPC分类号： A61K8/00
CPC分类号： A61K8/0204 , A61K8/11 , A61K8/19 , A61K8/21 , A61K2800/88 , A61Q11/00
摘要： A toothpaste filled in a container which has two chambers and is capable of simultaneously discharging two different compositions filled respectively in the two chambers when the main body of the container is pressed, wherein a ratio of a storage modulus GA′ of Composition (A) filled in one chamber to a storage modulus GB′ of Composition (B) filled in the other chamber falls within a range of from 0.6 to 1.4. By controlling the ratio, it is possible to stably discharge from the container storing these two compositions separately predetermined amounts of these two compositions which will otherwise cause a time-dependent change if they are pre-mixed thereby failing to attain the purpose of their addition.
摘要翻译： 填充在容器中的牙膏，其具有两个室，并且当容器的主体被挤压时能够同时排出分别填充在两个室中的两种不同组合物，其中填充的组合物（A）的储能模量GA' 在一个室中填充到另一个室中的组合物（B）的储能模量GB'在0.6至1.4的范围内。 通过控制比例，可以从容纳这两种组合物的容器中稳定地排出这些两种组合物的预定量，否则如果它们被预混合从而不能达到其添加目的，则会引起时间依赖性变化。
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5.发明申请公开(公告)号：US20050053557A1
公开(公告)日：2005-03-10
申请号：US10909316
申请日：2004-08-03
IPC分类号： A61K9/00 , A61K31/365 , C07D493/04 , A61K7/16
CPC分类号： C07D493/04 , A61K9/0063 , A61K31/365 , A61K36/14 , A61K36/237 , A61K36/29 , Y10S514/90 , Y10S514/901 , Y10S514/902
摘要： The present invention relates to a method for prevention or treatment of periodontal diseases, containing administering lignans represented by the following formula (1) (wherein R1 represents a hydrogen atom or a hydroxyl group; R2, R3, R4 and R5 are the same or different and each represents a hydrogen atom, a hydroxyl group, a C1-10 alkyl group, a hydroxy C1-10 alkyl group or a C1-10 alkoxy group) or plant extracts containing the lignans.
摘要翻译： 本发明涉及一种预防或治疗牙周疾病的方法，所述方法含有由下式（1）表示的给药木脂素（其中R 1表示氢原子或羟基; R 2，R 3， R 4和R 5相同或不同，各自表示氢原子，羟基，C 1-10烷基，羟基C 1-10烷基或C 1-10烷氧基）或植物 含有木脂素的提取物。
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公开(公告)号：US5374418A
公开(公告)日：1994-12-20
申请号：US16234
申请日：1993-02-11
申请人： Kazushi Oshino , Atsushi Yamagishi , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
发明人： Kazushi Oshino , Atsushi Yamagishi , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
IPC分类号： A61K8/41 , A61K8/43 , A61K8/44 , A61K8/49 , A61K8/55 , A61K8/63 , A61K8/66 , A61Q11/00 , A61K7/16 , A61K7/22
摘要： A composition for use in the oral cavity is disclosed. The composition comprises (A) an antibacterial compound represented by the following general formula (1),A.sup.m+ .multidot.X.sub.m.sup.- (1)wherein A.sup.m+ is a nitrogen-containing antibacterial cation and the counter anion X.sup.- represents a monoalkyl phosphate ion, a monoalkenyl phosphate ion, a monoalkyl phosphonate ion, or a monoalkenyl phosphonate ion having a linear or branched alkyl or alkenyl group with 8 to 20 carbon atoms, and m is a valence of the cation A, and (B) a vehicle for use in the oral cavity. It exhibits a remarkablely rapid and continued disinfection effect action against oral cavity bacteria, while providing a good taste. Its disinfection effect is not reduced in the presence of surfactants. In addition, it does not color the tooth.
摘要翻译： 公开了一种用于口腔中的组合物。 该组合物包含（A）由以下通式（1）表示的抗菌化合物，Am + xXm-（1）其中Am +为含氮抗菌阳离子，抗衡阴离子X为磷酸单烷基酯离子，单链烯基磷酸酯 离子，单烷基膦酸根离子或具有碳原子数为8〜20的直链或支链烷基或烯基的单烯基膦酸酯离子，m为阳离子A的化合价，（B）在口腔中使用的载体 。 它对口腔细菌表现出非常快速和持续的消毒效果，同时提供了良好的口味。 在表面活性剂存在下，其消毒效果不会降低。 此外，它不会使牙齿变色。
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公开(公告)号：US08591867B2
公开(公告)日：2013-11-26
申请号：US10540266
申请日：2003-12-26
摘要： An oral preparation of the present invention contains a multi-composition system including a calcium ion supplying compound; a fluoride ion supplying compound a polyolphosphate ion supplying compound; and, a monofluorophosphate ion supplying compound, wherein the calcium ion supplying compound and the fluoride ion supplying compound are separated within the oral preparation.
摘要翻译： 本发明的口服制剂含有包含钙离子供给化合物的多组合体系; 氟化物离子供给化合物，多元醇磷酸盐离子供给化合物; 以及供给化合物的单氟磷酸盐离子，其中，所述钙离子供给化合物和所述氟化物离子供给化合物在所述口服制剂中分离。
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公开(公告)号：US20070166243A1
公开(公告)日：2007-07-19
申请号：US10589396
申请日：2005-03-22
IPC分类号： A61K8/73
摘要： Provided is a dentifrice composition excellent in plaque and stain removing effect and feeling upon use. The dentifrice composition has the following components (A), (B) and (C): (A) from 0.2 to 3 weight % of powder cellulose; (B) a surfactant; and (C) from 10 to 30 weight % of an abrasive.
摘要翻译： 本发明提供了一种洁牙剂组合物，其在斑块和除斑效果以及使用感上均优异。 洁齿剂组合物具有以下组分（A），（B）和（C）：（A）0.2至3重量％的粉末纤维素; （B）表面活性剂; 和（C）10至30重量％的研磨剂。
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公开(公告)号：US20060134019A1
公开(公告)日：2006-06-22
申请号：US10540266
申请日：2003-12-26
IPC分类号： A61K8/21
摘要： An oral preparation of the present invention contains a multi-composition system including a calcium ion supplying compound; a fluoride ion supplying compound a polyolphosphate ion supplying compound; and, a monofluorophosphate ion supplying compound, wherein the calcium ion supplying compound and the fluoride ion supplying compound are separated within the oral preparation.
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公开(公告)号：US5370865A
公开(公告)日：1994-12-06
申请号：US16233
申请日：1993-02-11
申请人： Atsushi Yamagishi , Kazushi Oshino , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
发明人： Atsushi Yamagishi , Kazushi Oshino , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
IPC分类号： A61K8/34 , A61K8/43 , A61K8/44 , A61K8/49 , A61K8/55 , A61K8/63 , A61K8/67 , A61Q11/00 , A61K7/16 , A61K7/22
摘要： A composition for use in the oral cavity comprising a monophosphate represented by the following general formula (1), ##STR1## wherein R.sup.1 is a linear or branched alkyl or alkenyl group with 6 to 20 carbon atoms, and may have a substituted fluorine atom; one of X.sup.1 or X.sup.2 is a basic amino acid residual group, while the other is a hydrogen atom, an alkali metal, an ammonium, an alkyl amine, an alkanol amine, or a basic amino acid residual group; and n is an integer from 0 to 4. The composition exhibits a superior action in protecting the tooth surface, is stable, and has a pleasant taste.
摘要翻译： 一种用于口腔的组合物，其包含由以下通式（1）表示的单磷酸酯，其中R 1是具有6至20个碳原子的直链或支链烷基或烯基，并且可以具有取代基 氟原子 X1或X2中的一个是碱性氨基酸残基，而另一个是氢原子，碱金属，铵，烷基胺，链烷醇胺或碱性氨基酸残基; n为0〜4的整数。该组合物在保护牙齿表面方面表现出优异的作用，稳定，味道好。
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