Use of HIV-1 gp120 and gp160 proteins modified in the v3 loop for the preparation of vaccine compositions and formulations containing the same
    6.
    发明授权
    Use of HIV-1 gp120 and gp160 proteins modified in the v3 loop for the preparation of vaccine compositions and formulations containing the same 失效
    在v3环中修饰的HIV-1 gp120和gp160蛋白的使用用于制备疫苗组合物和含有该组合物的制剂

    公开(公告)号:US07063849B1

    公开(公告)日:2006-06-20

    申请号:US09632806

    申请日:2000-08-04

    IPC分类号: A61K39/21

    摘要: Use of HIV-1 gp120 and gp160 proteins which have been modified in the V3 loop for preparing vaccine compositions and formulations containing them which induce a systemic and mucosal immunity.Use of a recombinant HIV-1 Env protein, in which the V3 loop is partially or completely deleted, for preparing a vaccine composition which is capable of inducing an immunity which is at the same time humoral, cellular and mucosal with respect to HIV-1.The vaccine composition comprises:a recombinant Env protein as defined above,optionally at least one compound selected from the group consisting of: (1) the vaccination adjuvants selected from the group consisting of derivatives comprising divalent or trivalent ions: aluminium hydroxide or calcium phosphate, and muramylpeptide derivatives and (2) liposomes andoptionally at least one pharmaceutically acceptable vehicle.

    摘要翻译: 使用在V3环中修饰的HIV-1 gp120和gp160蛋白,用于制备疫苗组合物和含有它们的制剂,其诱导全身和粘膜免疫。 使用重组HIV-1 Env蛋白,其中V3环部分或完全缺失,用于制备疫苗组合物,其能够诱导相对于HIV-1的体液,细胞和粘膜的免疫力 。 疫苗组合物包含:如上定义的重组Env蛋白,任选的至少一种选自下组的化合物:(1)选自包含二价或三价离子的衍生物的接种佐剂:氢氧化铝或磷酸钙, 和胞壁酰肽衍生物和(2)脂质体和任选的至少一种药学上可接受的载体。

    Extrudable thermoplastic hydrocarbon compositions
    9.
    发明授权
    Extrudable thermoplastic hydrocarbon compositions 失效
    可挤压热塑性烃组合物

    公开(公告)号:US5710217A

    公开(公告)日:1998-01-20

    申请号:US559789

    申请日:1995-11-15

    摘要: This invention provides a melt-processable composition comprising, in admixture: (1) one or more melt-processable thermoplastic hydrocarbon polymers as the major component of the composition by weight, and, as a minor component of the composition by weight, (2) an effective amount of a chemically-resistant, fluoropolymer process aid to improve the processability of the composition. The fluoropolymer process aid contains at least about 50 weight percent of fluorine and comprises one or more fluoropolymers which are essentially completely ethylenically saturated.

    摘要翻译: 本发明提供了一种可熔融加工的组合物,其包含:(1)一种或多种可熔融加工的热塑性烃聚合物作为组合物的主要组分,并且作为组合物的重要组分的重要组分,(2) 有效量的耐化学性氟聚合物工艺有助于改善组合物的加工性能。 氟聚合物加工助剂含有至少约50重量%的氟并且包含一种或多种基本上完全烯属饱和的含氟聚合物。