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12 条记录 (耗时 0.039 秒)

    Device for oral administration of liquids
    8.
    发明授权
    Device for oral administration of liquids 失效
    口服液体装置

    公开(公告)号：US5354274A

    公开(公告)日：1994-10-11

    申请号：US932790

    申请日：1992-08-20

    申请人： Robert J. Demeter ,  Stephen F. Badylak ,  Kirk S. Foster ,  Leslie A. Geddes

    发明人： Robert J. Demeter ,  Stephen F. Badylak ,  Kirk S. Foster ,  Leslie A. Geddes

    IPC分类号： A61J7/00 ,  A61J9/00 ,  A61J11/00 ,  A61J17/00 ,  A61M31/00

    CPC分类号： A61J7/0046 ,  A61J11/00 ,  A61J17/006 ,  A61J7/0053 ,  A61J9/001 ,  A61J17/001

    摘要： A device is provided for facilitating oral administration of unit dosages of liquid formulations, particularly to pediatric and geriatric patients. Sealed cartridges containing unit doses of liquid nutrients or medications can be locked into the device and at the same time, breached so that the contained-liquid formulation can flow from the cartridge into a hollow nipple for facile oral consumption. The liquid formulation-contained sealed cartridge includes a container having a side wall collapsible responsive to withdrawal of liquid from the hollow nipple.

    摘要翻译： 提供了一种用于促进液体制剂的单位剂量的口服给药的装置，特别是对儿科和老年患者的口服给药。 包含单位剂量的液体营养物或药物的密封的药筒可以被锁定在装置中，并且同时被破坏，使得所含的液体制剂可以从药筒流入中空的乳头以便于口服消费。 液体制剂含有的密封筒包括容器，该容器具有可响应于从中空乳头抽出液体的可折叠的侧壁。

    Cell-type specific methods and devices for the low temperature preservation of the cells of an animal species
    9.
    发明授权
    Cell-type specific methods and devices for the low temperature preservation of the cells of an animal species 失效
    用于动物物种细胞的低温保存的细胞型特异性方法和装置

    公开(公告)号：US5776769A

    公开(公告)日：1998-07-07

    申请号：US485311

    申请日：1995-06-07

    申请人： John K. Critser ,  D. Y. Gao ,  Robert J. Demeter

    发明人： John K. Critser ,  D. Y. Gao ,  Robert J. Demeter

    IPC分类号： A01N1/02 ,  A61K35/52 ,  C12M3/06 ,  C12M1/12

    CPC分类号： A01N1/0263 ,  A01N1/0221 ,  A61K35/52

    摘要： A mathematical model, and membranes and devices based upon that model, to optimize protocols for the addition or removal of cryoprotectant to or from biological cells. This disclosure describes the use of four equations to predict optimal protocols to add or remove cryoprotectant to or from biological cells. The equations particularly require experimentally found data, specific to cell-type and species, regarding the osmotic tolerance of the cells, where osmotic tolerance refers to the cells ability to shrink or swell to various changes in osmolality without injury. The equations further require the cryoprotectant permeability coefficient and the water permeability coefficient of the particular cells' plasma membrane. These coefficients are found with experimental data of the knetic volume change of the cell-type to a known concentration and temperature of cryoprotectant. Also disclosed are particularly preferred methods and devices to add or remove cryoprotectant to or from these cells based upon these equations.

    摘要翻译： 数学模型，以及基于该模型的膜和装置，以优化用于向生物细胞或从生物细胞添加或除去冷冻保护剂的方案。 本公开描述了使用四个方程来预测最终方案以向生物细胞或从生物细胞添加或除去冷冻保护剂。 方程式特别需要关于细胞类型和物种特异性的实验发现的数据，关于细胞的渗透性耐受性，其中渗透性是指细胞在不损伤的情况下收缩或膨胀到各种重量摩尔渗透压变化的能力。 方程进一步要求特定细胞质膜的冷冻保护剂渗透系数和水渗透系数。 发现这些系数与细胞类型的体积变化的实验数据与已知的冷冻保护剂浓度和温度有关。 还公开了基于这些方程特别优选的方法和装置，以向这些细胞添加或除去冷冻保护剂。

    Percutaneous catheter with encapsulating receptacle
    10.
    发明授权
    Percutaneous catheter with encapsulating receptacle 失效
    经皮导管与封装容器

    公开(公告)号：US4997435A

    公开(公告)日：1991-03-05

    申请号：US411836

    申请日：1989-09-25

    申请人： Robert J. Demeter

    发明人： Robert J. Demeter

    IPC分类号： A61B17/22 ,  A61B17/30

    CPC分类号： A61B17/22 ,  A61B17/221 ,  A61B2017/22084 ,  A61B2017/2215 ,  A61B2017/303

    摘要： A percutaneous catheter with encapsulating receptacle comprises a first catheter having a proximal and distal end, several struts attached to the distal end of the first catheter and extending distally therefrom in a cup-shaped form, a second, inner catheter received within the first, and a pocket-shaped sheath received between the several struts and opening in the distal direction, the sheath having a proximal portion secured to the distal end of the second, inner catheter, and a distal portion secured to the distal ends of the several struts, whereby rotation of the first catheter, relative the second catheter, twists and closes the distal end of the sheath. A third, outer catheter is also disclosed within which the first and second catheters, and associated struts and sheath, are receivable. Also disclosed is a method for positioning the catheter adjacent an object, or receiving the object within the sheath and enclosing the sheath about the object to facilitate treatment of the object.

    摘要翻译： 具有封装容器的经皮导管包括具有近端和远端的第一导管，附接到第一导管的远端的多个支柱，并且以杯状形式从其向远端延伸，第二导管容纳在第一导管内， 一个袋形护套，其容纳在几个支柱之间并且在远端方向上开口，护套具有固定到第二内导管的远端的近端部分，以及固定到多个支柱的远端的远侧部分，由此 相对于第二导管，第一导管的旋转扭曲并闭合护套的远端。 还公开了第三个外导管，其中可接收第一和第二导管以及相关的支柱和护套。 还公开了一种用于将导管定位在物体附近，或者在护套内接收物体并围绕物体围绕护套以便于对象的处理的方法。