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公开(公告)号：US09216188B2
公开(公告)日：2015-12-22
申请号：US12553800
申请日：2009-09-03
IPC分类号： A61K9/00 , A61K31/00 , A61K31/7052 , A61L27/26 , A61L27/38 , A61L27/52 , C08J3/075 , C08J3/24
CPC分类号： A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要： The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
摘要翻译： 本发明提供水凝胶及其组合物，用于声带修复或增强，以及其它软组织修复或增强（例如，膀胱颈增大，皮肤填充剂，乳房植入物，椎间盘，肌肉质量）。 将水凝胶或其组合物注射到表层固有层或声音上皮中以恢复声带的声音粘膜，从而恢复患者的声音。 特别地，已经发现弹性剪切模量为约25Pa的水凝胶可用于恢复发音粘膜的柔韧性。 本发明还提供了制备和使用本发明水凝胶的方法。
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公开(公告)号：US20100055184A1
公开(公告)日：2010-03-04
申请号：US12553800
申请日：2009-09-03
IPC分类号： A61K9/00 , C07C43/11 , C07C31/18 , C07K14/00 , C08B37/00 , C08B37/02 , C08B37/04 , C07K14/78 , A61P19/04 , C08B15/06 , A61K35/00 , A61K35/12 , A61K38/02 , A61K38/16 , A61K31/7052
CPC分类号： A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要： The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
摘要翻译： 本发明提供水凝胶及其组合物，用于声带修复或增强，以及其它软组织修复或增强（例如，膀胱颈增大，皮肤填充剂，乳房植入物，椎间盘，肌肉质量）。 将水凝胶或其组合物注射到表层固有层或声音上皮中以恢复声带的声音粘膜，从而恢复患者的声音。 特别地，已经发现弹性剪切模量为约25Pa的水凝胶可用于恢复发音粘膜的柔韧性。 本发明还提供了制备和使用本发明水凝胶的方法。
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3.发明申请Methods and Systems of Matching Voice Deficits with a Tunable Mucosal Implant to Restore and Enhance Individualized Human Sound and Voice Production 有权将声音缺陷与可调式粘膜植入物相配套的方法与系统，以恢复和增强个性化人声和声音产生公开(公告)号：US20130041467A1
公开(公告)日：2013-02-14
申请号：US13579347
申请日：2011-03-04
IPC分类号： A61F2/00
CPC分类号： A61B1/2673 , A61L27/26 , A61L27/50 , C08L71/02
摘要： The disclosure relates to methods and systems for making customized treatments to a subject's vocal tissues to provide a desired level of vocal function.
摘要翻译： 本公开涉及用于对受试者的声乐组织进行定制治疗以提供期望水平的声带功能的方法和系统。
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4.发明授权Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production 有权将声音缺陷与可调粘膜植入物匹配的方法和系统，以恢复和增强个性化的人声和声音产生公开(公告)号：US09198568B2
公开(公告)日：2015-12-01
申请号：US13579347
申请日：2011-03-04
CPC分类号： A61B1/2673 , A61L27/26 , A61L27/50 , C08L71/02
摘要： The disclosure relates to methods and systems for making customized treatments to a subject's vocal tissues to provide a desired level of vocal function.
摘要翻译： 本公开涉及用于对受试者的声乐组织进行定制治疗以提供期望水平的声带功能的方法和系统。
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公开(公告)号：US20130303842A1
公开(公告)日：2013-11-14
申请号：US13817275
申请日：2011-09-02
申请人： Steven M. Zeitels , John C. Wain
发明人： Steven M. Zeitels , John C. Wain
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61L27/3604 , A61L27/3625 , A61L27/3679 , A61L27/3691 , A61L27/60 , A61L2430/22 , A61L2430/34
摘要： Compositions comprising aortic material and methods for using harvested blood vessels (e.g., arteries or veins e.g., aortae) graft procedures, e.g., for restoring and repairing luminal structures (e.g., in the aerodigestive tract, such as the larynx, pharynx, and esophagus); as tissue fillers (e.g., injectable morselized blood vessel tissues, for use in cosmetic applications and functional sphincter enhancement); and as biological structural supports (e.g., intact portions of aortae, for use in repairing abdominal wounds, anastomoses, bony repairs, and the heart).
摘要翻译： 包含主动脉材料的组合物和使用收获的血管（例如，动脉或静脉例如主动脉）移植程序的方法，例如用于恢复和修复腔内结构（例如，在呼吸消化道，例如喉，咽和食管） ; 作为组织填充剂（例如，可注射的微生物血管组织，用于化妆品应用和功能括约肌增强）; 以及作为生物结构支撑物（例如，用于修复腹部伤口，吻合，骨修复和心脏的主动脉的完整部分）。
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公开(公告)号：US20120065573A1
公开(公告)日：2012-03-15
申请号：US13147844
申请日：2010-02-05
申请人： Steven M. Zeitels
发明人： Steven M. Zeitels
CPC分类号： A61K31/00 , C07K16/22 , C07K2317/24 , C07K2317/54 , C07K2317/55
摘要： Described are methods of treating virus-associated lesions using administration of an anti-angiogenic compound, or a combination of angiolytic or ablative therapy and administration of an anti-angiogenic compound.
摘要翻译： 描述了使用施用抗血管生成化合物或血管分解或消融治疗和施用抗血管生成化合物的组合治疗病毒相关病变的方法。
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公开(公告)号：US09333036B2
公开(公告)日：2016-05-10
申请号：US13574472
申请日：2011-01-21
申请人： Adela Ben-Yakar , Christopher L. Hoy , William Neil Everett , James B. Kobler , Richard Rox Anderson , William A. Farinelli , Steven M. Zeitels
发明人： Adela Ben-Yakar , Christopher L. Hoy , William Neil Everett , James B. Kobler , Richard Rox Anderson , William A. Farinelli , Steven M. Zeitels
CPC分类号： A61B18/20 , A61B2017/00057 , A61B2018/20351
摘要： Provided herein are devices, systems and methods for treating a vocal fold pathology by forming a substantially planar void below the epithelium of the vocal fold using optical energy. Also provided are devices, systems, and methods for combined imaging and treating of a vocal fold pathology.
摘要翻译： 本文提供了通过使用光能在声带的上皮下方形成基本平坦的空隙来治疗声带折叠病理学的装置，系统和方法。 还提供了用于组合成像和治疗声带折叠病理学的装置，系统和方法。
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公开(公告)号：US5092314A
公开(公告)日：1992-03-03
申请号：US520647
申请日：1990-05-08
申请人： Steven M. Zeitels
发明人： Steven M. Zeitels
CPC分类号： A61B1/267 , A61B1/32 , A61B17/0218
摘要： An adjustable supraglottiscope designed to be used in the supraglottic larynx is disclosed, in particular, an improved apparatus for endoscopic surgery in the supraglottis and the lower pharynx is disclosed by having at least one blade that is at least as wide as the normal, human epiglottis in its natural position within the body. The blades of the supraglottiscope have a length to width ratio that is about one-half of that found in conventional instruments. This unique ratio enables a wider exposure of the supraglottic larynx and lower pharynx. Methods of performing surgery on the supraglottic larynx of a patient are also described.
摘要翻译： 公开了一种设计用于声门上喉镜的可调节超视距镜，特别是用于上喉内窥镜手术的改进装置，并且通过具有至少一个与正常人会厌 在其身体内的自然位置。 超声波扫描镜的刀片具有长度与宽度之比，约为常规仪器中的一半。 这种独特的比例使得声门上喉和下咽更广泛。 还描述了对患者的声门上喉进行手术的方法。
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公开(公告)号：US09186336B2
公开(公告)日：2015-11-17
申请号：US13147844
申请日：2010-02-05
申请人： Steven M. Zeitels
发明人： Steven M. Zeitels
CPC分类号： A61K31/00 , C07K16/22 , C07K2317/24 , C07K2317/54 , C07K2317/55
摘要： Described are methods of treating virus-associated lesions using administration of an anti-angiogenic compound, or a combination of angiolytic or ablative therapy and administration of an anti-angiogenic compound.
摘要翻译： 描述了使用施用抗血管生成化合物或血管分解或消融治疗和施用抗血管生成化合物的组合治疗病毒相关病变的方法。
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公开(公告)号：US20130211391A1
公开(公告)日：2013-08-15
申请号：US13574472
申请日：2011-01-21
申请人： Adela BenYakar , Christopher L. Hoy , William Neil Everett , James B. Kobler , Richard Rox Anderson , William A. Farinelli , Steven M. Zeitels
发明人： Adela BenYakar , Christopher L. Hoy , William Neil Everett , James B. Kobler , Richard Rox Anderson , William A. Farinelli , Steven M. Zeitels
IPC分类号： A61B18/20
CPC分类号： A61B18/20 , A61B2017/00057 , A61B2018/20351
摘要： Provided herein are devices, systems and methods for treating a vocal fold pathology by forming a substantially planar void below the epithelium of the vocal fold using optical energy. Also provided are devices, systems, and methods for combined imaging and treating of a vocal fold pathology.
摘要翻译： 本文提供了通过使用光能在声带的上皮下方形成基本平坦的空隙来治疗声带折叠病理学的装置，系统和方法。 还提供了用于组合成像和治疗声带折叠病理学的装置，系统和方法。
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