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公开(公告)号:US09333036B2
公开(公告)日:2016-05-10
申请号:US13574472
申请日:2011-01-21
申请人: Adela Ben-Yakar , Christopher L. Hoy , William Neil Everett , James B. Kobler , Richard Rox Anderson , William A. Farinelli , Steven M. Zeitels
发明人: Adela Ben-Yakar , Christopher L. Hoy , William Neil Everett , James B. Kobler , Richard Rox Anderson , William A. Farinelli , Steven M. Zeitels
CPC分类号: A61B18/20 , A61B2017/00057 , A61B2018/20351
摘要: Provided herein are devices, systems and methods for treating a vocal fold pathology by forming a substantially planar void below the epithelium of the vocal fold using optical energy. Also provided are devices, systems, and methods for combined imaging and treating of a vocal fold pathology.
摘要翻译: 本文提供了通过使用光能在声带的上皮下方形成基本平坦的空隙来治疗声带折叠病理学的装置,系统和方法。 还提供了用于组合成像和治疗声带折叠病理学的装置,系统和方法。
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公开(公告)号:US08894637B2
公开(公告)日:2014-11-25
申请号:US12811888
申请日:2009-01-22
CPC分类号: G01B9/04 , A61B5/0059 , A61B5/0066 , A61B5/6852 , A61B18/20 , A61B90/20 , A61B2018/20351 , G01N21/4795 , G01N21/6458
摘要: Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.
摘要翻译: 本文提供了用于生物组织成像的装置,系统和方法。 还提供了用于生物组织的外科手术操作的装置,系统和方法。 还提供了用于生物组织的组合成像和外科手术操作的装置,系统和方法。
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公开(公告)号:US20100286674A1
公开(公告)日:2010-11-11
申请号:US12811888
申请日:2009-01-22
CPC分类号: G01B9/04 , A61B5/0059 , A61B5/0066 , A61B5/6852 , A61B18/20 , A61B90/20 , A61B2018/20351 , G01N21/4795 , G01N21/6458
摘要: Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.
摘要翻译: 本文提供了用于生物组织成像的装置,系统和方法。 还提供了用于生物组织的外科手术操作的装置,系统和方法。 还提供了用于生物组织的组合成像和外科手术操作的装置,系统和方法。
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公开(公告)号:US20090072161A1
公开(公告)日:2009-03-19
申请号:US12184628
申请日:2008-08-01
申请人: Adela Ben-Yakar , Daniel Eversole , Xun Guo
发明人: Adela Ben-Yakar , Daniel Eversole , Xun Guo
IPC分类号: G21G5/00
CPC分类号: A61B18/20 , A61B5/0059 , B23K26/0624 , B23K2103/32 , B23K2103/50 , Y10S428/913
摘要: A novel femtosecond laser nano-ablation technique called Plasmonic Laser Nano-Ablation (PLN). The technique takes advantage of surface-enhanced plasmonic scattering of ultrashort laser pulses by nanoparticles to vaporize sub-cellular structures in attoliter volumes. The use of nanoparticles may overcome problems associated with current FLMS techniques and does not rely on heating for nanodisruption. In PLN, the particle acts as a “nano-lens,” restricting laser light to the near-field of the particle, and only photodisrupting structures that are nanometers away. This eliminates the need for a tightly focused beam, while still achieving nanoscale ablation resolution. Moreover, the enhanced scattering around the particles reduces the amount of required laser fluence. A method is provided comprising positioning a nanoparticle in proximity to a surface of a material; irradiating the nanoparticle with a laser tuned close to the nanoparticle's plasmonic frequency; and allowing a near-field effect from the irradiated nanoparticle to photodamage the material.
摘要翻译: 一种新颖的飞秒激光纳米消融技术,称为等离子体激光纳米消融(PLN)。 该技术利用纳米颗粒的超短激光脉冲的表面增强等离子体激发散射来以甲酰胺体积蒸发亚细胞结构。 使用纳米颗粒可以克服与当前FLMS技术相关的问题,并且不依赖于加热用于纳米破坏。 在PLN中,粒子作为“纳米透镜”,将激光限制在粒子的近场,并且只有纳米远的光致断层结构。 这消除了对紧密聚焦光束的需要,同时仍然实现纳米尺度的消融分辨率。 此外,颗粒周围的增强散射减少了所需的激光注量。 提供了一种方法,包括将纳米颗粒定位在材料表面附近; 用接近纳米颗粒等离子体激发频率的激光照射纳米颗粒; 并且允许来自照射的纳米颗粒的近场效应对材料进行光损伤。
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公开(公告)号:US07834331B2
公开(公告)日:2010-11-16
申请号:US12184628
申请日:2008-08-01
申请人: Adela Ben-Yakar , Daniel Eversole , Xun Guo
发明人: Adela Ben-Yakar , Daniel Eversole , Xun Guo
CPC分类号: A61B18/20 , A61B5/0059 , B23K26/0624 , B23K2103/32 , B23K2103/50 , Y10S428/913
摘要: A novel femtosecond laser nano-ablation technique called Plasmonic Laser Nano-Ablation (PLN). The technique takes advantage of surface-enhanced plasmonic scattering of ultrashort laser pulses by nanoparticles to vaporize sub-cellular structures in attoliter volumes. The use of nanoparticles may overcome problems associated with current FLMS techniques and does not rely on heating for nanodisruption. In PLN, the particle acts as a “nano-lens,” restricting laser light to the near-field of the particle, and only photodisrupting structures that are nanometers away. This eliminates the need for a tightly focused beam, while still achieving nanoscale ablation resolution. Moreover, the enhanced scattering around the particles reduces the amount of required laser fluence. A method is provided comprising positioning a nanoparticle in proximity to a surface of a material; irradiating the nanoparticle with a laser tuned close to the nanoparticle's plasmonic frequency; and allowing a near-field effect from the irradiated nanoparticle to photodamage the material.
摘要翻译: 一种新颖的飞秒激光纳米消融技术,称为等离子体激光纳米消融(PLN)。 该技术利用纳米颗粒的超短激光脉冲的表面增强等离子体激发散射来以甲酰胺体积蒸发亚细胞结构。 使用纳米颗粒可以克服与当前FLMS技术相关的问题,并且不依赖于加热用于纳米破坏。 在PLN中,粒子作为“纳米透镜”,将激光限制在粒子的近场,并且只有纳米远的光致断层结构。 这消除了对紧密聚焦光束的需要,同时仍然实现纳米尺度的消融分辨率。 此外,颗粒周围的增强散射减少了所需的激光注量。 提供了一种方法,包括将纳米颗粒定位在材料表面附近; 用接近纳米颗粒等离子体激发频率的激光照射纳米颗粒; 并且允许来自照射的纳米颗粒的近场效应对材料进行光损伤。
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