公开(公告)号：US06613792B1

公开(公告)日：2003-09-02

申请号：US09365425

申请日：1999-08-02

申请人： Suzanne R. Ellenberger ,  William P. Ellenberger ,  G. Merrill Andrus

发明人： Suzanne R. Ellenberger ,  William P. Ellenberger ,  G. Merrill Andrus

IPC分类号： A61K31405

CPC分类号： A61K31/407 ,  A61K31/4035 ,  A61K31/7056

摘要： A method of treating premenstrual syndrome and menopausal symptoms in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound (e.g., 1H-indole-3-methanol; ascorbigen) in a medically acceptable manner in a pharmaceutically effective amount. It has been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of PMS. Patients with PMS have reported decreased menstrual cramping, decreased menstrual flow, shorter duration of menses, decreased fatigue, less frequent headaches, improved mood, and decreased bloating resulting from the oral administration each day or during specific portions of the menstrual cycle of pharmaceutically effective amounts of dietary indoles derived from 1H-indole-3-methanol. It has also been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of menopause.

摘要翻译： 一种治疗患者经前期综合征和绝经期症状的方法，所述方法包括：以医学上可接受的方式向患者施用1H-吲哚-3-甲醇化合物（例如，1H-吲哚-3-甲醇;抗坏血酸） 药学有效量。 已经发现，这种吲哚，特别是1H-吲哚-3-甲醇的给药大大减轻了PMS的症状。 患有PMS的患者报告月经周期减少，月经流量减少，月经持续时间缩短，疲劳减轻，头痛减轻，情绪改善，口气恶化，以及口服给药每天或在月经周期的特定部分期间药物有效量 的衍生自1H-吲哚-3-甲醇的膳食吲哚。 还发现这种吲哚，特别是1H-吲哚-3-甲醇的给药大大减轻了更年期症状。

公开(公告)号：US5229007A

公开(公告)日：1993-07-20

申请号：US870294

申请日：1992-04-17

申请人： William P. Ellenberger ,  Suzanne R. Ellenberger

发明人： William P. Ellenberger ,  Suzanne R. Ellenberger

IPC分类号： A23L5/20 ,  A62D3/00

CPC分类号： A01N65/26 ,  A01N43/90 ,  A23L5/273

摘要： A method for the selective removal of contaminants, including aflatoxin, from azadirachtin-containing materials comprising contacting said materials with a binding agent capable of selectively binding contaminants compared to azadirachtin.

摘要翻译： 一种用于从含印苦楝子素材料中选择性除去包括黄曲霉毒素在内的污染物的方法，包括使所述材料与印楝素相比能够选择性地结合污染物的结合剂。

公开(公告)号：US5443978A

公开(公告)日：1995-08-22

申请号：US82844

申请日：1993-06-25

申请人： Suzanne R. Ellenberger ,  Galen D. Peiser ,  Russell N. Bell ,  Charles E. Hussey, Jr. ,  Donna M. Shattuck-Eidens ,  Bradley D. Swedlund

发明人： Suzanne R. Ellenberger ,  Galen D. Peiser ,  Russell N. Bell ,  Charles E. Hussey, Jr. ,  Donna M. Shattuck-Eidens ,  Bradley D. Swedlund

IPC分类号： C12N15/09 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12P9/00 ,  C12R1/19 ,  C12R1/865

CPC分类号： C12N9/1085

摘要： This invention provides a purified chrysanthemyl diphosphate synthase (CDS), a method for the purification of CDS from Chrysanthemum cinerariaefolium, and an amino acid sequence of the isolated CDS. Also provided is a cDNA encoding the CDS, a nucleotide sequence of the CDS gene, and a derived amino acid sequence of the encoded CDS protein. The CDS gene is useful in the enzymatic production of the natural stereospecific configuration of chrysanthemyl derivatives which are useful for the synthesis of pyrethrins, pyrethroids, derivatives thereof, as well as other classes of metabolites.

摘要翻译： 本发明提供了一种纯化的菊花二磷酸合成酶（CDS），一种从菊花中纯化CDS的方法和分离的CDS的氨基酸序列。 还提供了编码CDS的cDNA，CDS基因的核苷酸序列和编码的CDS蛋白的衍生氨基酸序列。 CDS基因可用于天然立体特异性构型的菊花衍生物的酶促生产，其可用于合成除虫菊酯，拟除虫菊酯，其衍生物以及其它类别的代谢物。

公开(公告)号：US5395827A

公开(公告)日：1995-03-07

申请号：US171629

申请日：1993-12-22

申请人： Waclaw J. Rzeszotarski ,  Suzanne R. Ellenberger ,  Maria E. Guzewska ,  John W. Ferkany ,  Gregory S. Hamilton ,  Raymond J. Patch ,  Edward W. Karbon, Jr

发明人： Waclaw J. Rzeszotarski ,  Suzanne R. Ellenberger ,  Maria E. Guzewska ,  John W. Ferkany ,  Gregory S. Hamilton ,  Raymond J. Patch ,  Edward W. Karbon, Jr

IPC分类号： A61K31/66 ,  C07F9/38

CPC分类号： C07F9/3882 ,  A61K31/66 ,  C07F9/3834

摘要： The present invention pertains to antagonists of excitatory amino acid neurotransmitter receptor antagonists, their method of preparation as well as compositions containing them which have the general formula: ##STR1## wherein n and m independently are 0, 1, 2, or 3; R.sub.1 is selected from the group consisting of hydrogen and R.sub.2 ; R.sub.2 is selected from the group consisting of hydrogen, halogen, halomethyl, nitro, amino, alkoxy, hydroxyl, hydroxymethyl, C.sub.1 to C.sub.6 lower alkyl, C.sub.7 to C.sub.12 higher alkyl, aryl and aralkyl, wherein if R.sub.2 is hydrogen, R.sub.1 is not hydrogen; R.sub.3 is selected from the group consisting of hydrogen and C.sub.1 to C.sub.6 lower alkyl; the stereoisomers thereof in their resolved or racemic form, and pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及兴奋性氨基酸神经递质受体拮抗剂的拮抗剂，它们的制备方法以及含有它们的组合物，它们具有以下通式：其中n和m独立地是0,1,2或3; R1选自氢和R2; R2选自氢，卤素，卤代甲基，硝基，氨基，烷氧基，羟基，羟甲基，C1至C6低级烷基，C7至C12高级烷基，芳基和芳烷基，其中如果R2是氢，R1不是氢 ; R3选自氢和C1至C6低级烷基; 其立体异构体以其分辨或外消旋形式，及其药学上可接受的盐。

公开(公告)号：US5049555A

公开(公告)日：1991-09-17

申请号：US286153

申请日：1988-12-19

申请人： Waclaw J. Rzeszotarski ,  Maria E. Guzewska ,  Suzanne R. Ellenberger ,  Lisa H. Conti ,  John W. Ferkany ,  Donald J. Kyle

发明人： Waclaw J. Rzeszotarski ,  Maria E. Guzewska ,  Suzanne R. Ellenberger ,  Lisa H. Conti ,  John W. Ferkany ,  Donald J. Kyle

IPC分类号： A61K31/66

CPC分类号： A61K31/66

摘要： The invention pertains to a method and pharmaceutical compositions for treating, preventing or reducing neurodegeneration associated with chronic central nervous system or hypoxic, ischemic and hypoglycemic injury to the central nervous system and for the treatment of anxiety through the use of 2-amino-.omega.-phosphonoalkanoic acids having a cycloalkyl group bridging adjacent carbons on the alkyl chain, their pharmaceutically acceptable salts and derivatives as neuroprotectants and anxiolytics.

摘要翻译： 本发明涉及用于治疗，预防或减少与中枢神经系统的慢性中枢神经系统或缺氧，缺血和低血糖损伤有关的神经退行性疾病和通过使用2-氨基-ω- 在烷基链上具有邻接碳原子的环烷基的膦酰基链烷酸，其药学上可接受的盐和衍生物作为神经保护剂和抗焦虑剂。