公开(公告)号：US20070190103A1

公开(公告)日：2007-08-16

申请号：US11351598

申请日：2006-02-10

Applicant: Syed Hossainy ,  Stephen Pacetti ,  Murthy Simhambhatla

Inventor： Syed Hossainy ,  Stephen Pacetti ,  Murthy Simhambhatla

IPC: A61K31/4745 ,  A61K31/395

CPC classification number: A61L27/34 ,  A61K31/395 ,  A61K31/4745 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  C08L67/04

Abstract: The present invention relates to an implantable medical device comprising therapeutic agents coated on the device using polyesters for the drug reservoir layer that exhibit surface-eroding characteristics.

Abstract translation: 本发明涉及可植入医疗装置，其包括使用展示表面侵蚀特征的药物储存层的聚酯涂覆在该装置上的治疗剂。

公开(公告)号：US20060265043A1

公开(公告)日：2006-11-23

申请号：US11388355

申请日：2006-03-24

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61B5/02007 ,  A61B2017/22077 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/077 ,  A61F2220/0058 ,  A61F2250/0067 ,  A61M1/3613 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1086 ,  A61M2025/1095

Abstract: Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

Abstract translation: 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

公开(公告)号：US20070110787A1

公开(公告)日：2007-05-17

申请号：US11644771

申请日：2006-12-21

Applicant: Syed Hossainy ,  Murthy Simhambhatla

Inventor： Syed Hossainy ,  Murthy Simhambhatla

IPC: A61L33/00 ,  A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2400/12

Abstract: Coatings for implantable medical devices including nanoparticles incorporating an active agent, and methods for fabricating the coatings.

Abstract translation: 用于可植入医疗装置的涂层，包括掺入活性剂的纳米颗粒，以及制造涂层的方法。

公开(公告)号：US07008411B1

公开(公告)日：2006-03-07

申请号：US10262151

申请日：2002-09-30

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

IPC: A61M31/00 ,  A61M5/178

CPC classification number: A61M25/0084 ,  A61B2017/22081 ,  A61M25/0026 ,  A61M25/1006 ,  A61M2025/0096

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送生物活性剂以稳定易损斑块。

公开(公告)号：US20060135943A1

公开(公告)日：2006-06-22

申请号：US11283032

申请日：2005-11-17

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

IPC: A61M31/00

CPC classification number: A61M25/0084 ,  A61B2017/22081 ,  A61M25/0026 ,  A61M25/1006 ,  A61M2025/0096

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

公开(公告)号：US20160184595A1

公开(公告)日：2016-06-30

申请号：US14650818

申请日：2013-12-18

Applicant: Syed HOSSAINY ,  ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Syed Hossainy

IPC: A61N1/375 ,  A61M39/02 ,  A61F7/12 ,  A61N1/378 ,  A61N1/362

CPC classification number: A61N1/3756 ,  A61F7/12 ,  A61F2007/126 ,  A61M39/0247 ,  A61M2039/0258 ,  A61M2039/0261 ,  A61N1/3627 ,  A61N1/3785

Abstract: Various medical implants and methods of using the implants are disclosed. In an embodiment, the implants include piezoelectric polymers for treating unwanted medical conditions of a patient. The medical implants may be delivered to an organ of the patient to treat conditions of those organs.

Abstract translation: 公开了各种医疗植入物和使用植入物的方法。 在一个实施方案中，植入物包括用于治疗患者的不需要的医疗状况的压电聚合物。 医疗植入物可以被递送到患者的器官以治疗那些器官的状况。

公开(公告)号：US20120276152A1

公开(公告)日：2012-11-01

申请号：US13366841

申请日：2012-02-06

Applicant: Syed Hossainy ,  John Stankus ,  Mikael Trollsas ,  Dariush Davalian

Inventor： Syed Hossainy ,  John Stankus ,  Mikael Trollsas ,  Dariush Davalian

IPC: A61K9/00 ,  A61K31/351 ,  A61K31/4412 ,  A61K31/44 ,  A61K38/02 ,  A61K31/734 ,  A61K31/045 ,  A61K33/26 ,  A61K31/04 ,  A61K31/519 ,  A61K31/4985 ,  A61K31/352 ,  A61K38/22 ,  A61K31/198 ,  A61K33/00 ,  A61K31/502 ,  A61K47/30 ,  A61P9/10 ,  A61K31/16

CPC classification number: A61K31/16 ,  A61K31/04 ,  A61K31/045 ,  A61K31/198 ,  A61K31/351 ,  A61K31/352 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4985 ,  A61K33/30 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods and systems for treating an infarct by delivery of zinc chelator to modulate tissue.

Abstract translation: 通过递送锌螯合剂来调节组织来治疗梗死的方法和系统。

公开(公告)号：US20110319866A1

公开(公告)日：2011-12-29

申请号：US13098055

申请日：2011-04-29

Applicant: Paul CONSIGNY ,  Kevin J. Ehrenreich ,  Jesus Magana ,  Syed Hossainy

Inventor： Paul CONSIGNY ,  Kevin J. Ehrenreich ,  Jesus Magana ,  Syed Hossainy

IPC: A61M25/10

CPC classification number: A61M25/10184 ,  A61M25/10181 ,  A61M25/10186 ,  A61M25/104 ,  A61M2025/105

Abstract: A method for synergistic mitigation of reperfusion injury after an ischemia event in a subject.

Abstract translation: 一种在受试者缺血事件后协同减轻再灌注损伤的方法。

公开(公告)号：US20110270225A1

公开(公告)日：2011-11-03

申请号：US13098092

申请日：2011-04-29

Applicant: Kevin J. EHRENREICH ,  Jesus Magana ,  Paul Consigny ,  Syed Hossainy

Inventor： Kevin J. EHRENREICH ,  Jesus Magana ,  Paul Consigny ,  Syed Hossainy

IPC: A61M25/10

CPC classification number: A61M25/0021 ,  A61M25/1002 ,  A61M25/10184 ,  A61M25/10185 ,  A61M25/10187 ,  A61M25/104 ,  A61M2025/004 ,  A61M2025/0081 ,  A61M2025/105 ,  A61M2025/1088 ,  A61M2039/248

Abstract: A method for improving tissue uptake of beneficial agent and ejection fraction.

Abstract translation: 一种改善有益药物和射血分数的组织吸收的方法。

公开(公告)号：US20110190871A1

公开(公告)日：2011-08-04

申请号：US13015488

申请日：2011-01-27

Applicant: Mikael Trollsas ,  Michael H. Ngo ,  Boris Anukhin ,  Alexander Nikanorov ,  Syed Hossainy ,  John Papp ,  Dudley Jayasinghe ,  Zella Solter

Inventor： Mikael Trollsas ,  Michael H. Ngo ,  Boris Anukhin ,  Alexander Nikanorov ,  Syed Hossainy ,  John Papp ,  Dudley Jayasinghe ,  Zella Solter

IPC: A61F2/82

CPC classification number: A61F2/958 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/9522 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0076 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2250/0067 ,  A61F2250/0096 ,  A61F2250/0098 ,  A61L27/00 ,  A61L31/06 ,  A61L31/14 ,  B21D39/046 ,  B29C35/08 ,  B29C2035/0838 ,  B29K2067/046 ,  B29L2023/00 ,  B29L2031/7543 ,  Y10T29/49826 ,  Y10T29/4987 ,  Y10T29/49908 ,  Y10T29/49925 ,  Y10T29/49927 ,  C08L67/04 ,  C08L71/02

Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.

Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架具有图案，其包括连接连接封闭单元的链接的非对称封闭单元。