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公开(公告)号：US08821473B2
公开(公告)日：2014-09-02
申请号：US12632612
申请日：2009-12-07
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00 , A61K31/7088 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US08512737B1
公开(公告)日：2013-08-20
申请号：US12132570
申请日：2008-06-03
IPC分类号： A61K9/0024 , A61K9/1647 , A61K27/54 , A61K27/18 , A61K27/58 , A61K35/34 , A61K38/00 , A61K35/44
CPC分类号： A61K9/1647
摘要： This application is directed to means for embolic delivery of therapeutic agents to an afflicted organ in the body of a patient.
摘要翻译： 本申请涉及用于将治疗剂栓塞递送至患者体内受影响的器官的手段。
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公开(公告)号：US08470358B2
公开(公告)日：2013-06-25
申请号：US13276666
申请日：2011-10-19
CPC分类号： A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
摘要： Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
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公开(公告)号：US20120034222A1
公开(公告)日：2012-02-09
申请号：US13276666
申请日：2011-10-19
CPC分类号： A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
摘要： Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
摘要翻译： 提供了具有能够催化体内产生一氧化氮的催化剂的医疗装置和使用该装置治疗血管状态的方法。
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公开(公告)号：US08067025B2
公开(公告)日：2011-11-29
申请号：US11726135
申请日：2007-03-20
CPC分类号： A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
摘要： Medical devices having a catalyst capable of catalyzing the generation of nitric oxide attached to the medical device and methods of treating a vascular condition using the devices are provided.
摘要翻译： 提供了具有能够催化附着于医疗装置的一氧化氮的产生的催化剂的医疗装置和使用该装置治疗血管状态的方法。
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6.发明授权公开(公告)号：US08017140B2
公开(公告)日：2011-09-13
申请号：US11804997
申请日：2007-05-21
申请人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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7.发明申请公开(公告)号：US20100233263A1
公开(公告)日：2010-09-16
申请号：US12789002
申请日：2010-05-27
IPC分类号： A61K9/14 , A61K33/00 , A61K31/198 , A61P9/10 , A61M25/00
CPC分类号： A61K33/00 , A61K9/00 , A61K31/198 , A61K38/005 , A61K38/44 , A61L27/38 , A61L29/16 , A61L31/16 , A61L2300/40
摘要： Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.
摘要翻译： 本文公开了在身体损伤部位诱导细胞例如巨噬细胞凋亡的方法和组合物。 一氧化氮可以直接或间接地递送到治疗部位以增加巨噬细胞凋亡。 交付可以包括一氧化氮气体，一氧化氮在水溶液中的位置特异性递送或释放一氧化氮或从内源产生一氧化氮的物质。 可以通过诸如导管组件，支架或其它合适的装置之类的递送系统实现递送。
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公开(公告)号：US07641643B2
公开(公告)日：2010-01-05
申请号：US10414767
申请日：2003-04-15
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00
CPC分类号： A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US20070032853A1
公开(公告)日：2007-02-08
申请号：US10108004
申请日：2002-03-27
申请人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
IPC分类号： A61F2/06
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.
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10.发明申请公开(公告)号：US20060105019A1
公开(公告)日：2006-05-18
申请号：US11322282
申请日：2005-12-29
申请人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Sayed Hossainy
发明人： Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Sayed Hossainy
IPC分类号： A61K31/4745 , A61F2/00
CPC分类号： A61K31/4745 , A61F2250/0067 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
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