公开(公告)号：US20070190103A1

公开(公告)日：2007-08-16

申请号：US11351598

申请日：2006-02-10

Applicant: Syed Hossainy ,  Stephen Pacetti ,  Murthy Simhambhatla

Inventor： Syed Hossainy ,  Stephen Pacetti ,  Murthy Simhambhatla

IPC: A61K31/4745 ,  A61K31/395

CPC classification number: A61L27/34 ,  A61K31/395 ,  A61K31/4745 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  C08L67/04

Abstract: The present invention relates to an implantable medical device comprising therapeutic agents coated on the device using polyesters for the drug reservoir layer that exhibit surface-eroding characteristics.

Abstract translation: 本发明涉及可植入医疗装置，其包括使用展示表面侵蚀特征的药物储存层的聚酯涂覆在该装置上的治疗剂。

公开(公告)号：US20060135943A1

公开(公告)日：2006-06-22

申请号：US11283032

申请日：2005-11-17

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

IPC: A61M31/00

CPC classification number: A61M25/0084 ,  A61B2017/22081 ,  A61M25/0026 ,  A61M25/1006 ,  A61M2025/0096

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

公开(公告)号：US20060265043A1

公开(公告)日：2006-11-23

申请号：US11388355

申请日：2006-03-24

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61B5/02007 ,  A61B2017/22077 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/077 ,  A61F2220/0058 ,  A61F2250/0067 ,  A61M1/3613 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1086 ,  A61M2025/1095

Abstract: Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

Abstract translation: 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

公开(公告)号：US20070110787A1

公开(公告)日：2007-05-17

申请号：US11644771

申请日：2006-12-21

Applicant: Syed Hossainy ,  Murthy Simhambhatla

Inventor： Syed Hossainy ,  Murthy Simhambhatla

IPC: A61L33/00 ,  A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2400/12

Abstract: Coatings for implantable medical devices including nanoparticles incorporating an active agent, and methods for fabricating the coatings.

Abstract translation: 用于可植入医疗装置的涂层，包括掺入活性剂的纳米颗粒，以及制造涂层的方法。

公开(公告)号：US07008411B1

公开(公告)日：2006-03-07

申请号：US10262151

申请日：2002-09-30

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

IPC: A61M31/00 ,  A61M5/178

CPC classification number: A61M25/0084 ,  A61B2017/22081 ,  A61M25/0026 ,  A61M25/1006 ,  A61M2025/0096

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送生物活性剂以稳定易损斑块。

公开(公告)号：US07326238B1

公开(公告)日：2008-02-05

申请号：US10262149

申请日：2002-09-30

Applicant: Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

Inventor： Deborah Kilpatrick ,  Murthy Simhambhatla ,  Santosh Prabhu ,  Shawn Chin Quee

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61B17/22 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L27/3808 ,  A61L27/3843 ,  A61L31/16 ,  A61M25/0084 ,  A61M29/02 ,  A61M2025/0086

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.

Abstract translation: 一种治疗易损斑块的装置和方法。 在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。 在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。 可扩张管屏蔽易损斑块与体腔。

公开(公告)号：US20050222584A1

公开(公告)日：2005-10-06

申请号：US11140240

申请日：2005-05-26

Applicant: Deborah Kilpatrick ,  Robert Ainsworth ,  Murthy Simhambhatla ,  Jeong Lee

Inventor： Deborah Kilpatrick ,  Robert Ainsworth ,  Murthy Simhambhatla ,  Jeong Lee

IPC: A61F2/06 ,  A61F2/84 ,  A61F11/00 ,  A61M29/00

CPC classification number: A61F2/958 ,  A61B2017/22081

Abstract: A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.

Abstract translation: 一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。 该过程在损伤或破裂部位产生ECM合成的显着增加。 因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。 本发明的方法特别可用于治疗纤维腺瘤型易损斑块。 在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。 在替代实施例中，使用直径限制装​​置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。

公开(公告)号：US08747385B2

公开(公告)日：2014-06-10

申请号：US13468956

申请日：2012-05-10

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M31/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

公开(公告)号：US08383158B2

公开(公告)日：2013-02-26

申请号：US10414602

申请日：2003-04-15

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61K9/14

CPC classification number: A61N1/3625 ,  A61K9/0024 ,  A61K31/00 ,  A61K31/728 ,  A61K31/732 ,  A61K31/734 ,  A61K31/78 ,  A61K31/79 ,  A61K36/886 ,  A61K38/40 ,  A61K41/0042 ,  A61K45/06 ,  A61K47/02 ,  A61K47/34 ,  A61K47/60 ,  A61K47/62 ,  A61K49/0404 ,  A61L24/043 ,  A61L27/20 ,  A61L27/50 ,  A61L27/54 ,  A61L2430/20 ,  A61N1/36521 ,  A61K2300/00

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些试剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US20100144635A1

公开(公告)日：2010-06-10

申请号：US12632612

申请日：2009-12-07

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M37/00 ,  A61M25/00 ,  A61K38/22 ,  A61K31/7088 ,  A61K47/34 ,  A61P9/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。