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    NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
    6.
    发明申请
    NITROGEN-CONTAINING HETEROCYCLIC COMPOUND 有权
    含氮杂环化合物

    公开(公告)号：US20150307497A1

    公开(公告)日：2015-10-29

    申请号：US14443598

    申请日：2013-11-18

    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

    Inventor： Takahiro SUGIMOTO ,  Minoru NAKAMURA ,  Hiroki SAKAMOTO ,  Shinkichi SUZUKI ,  Masami YAMADA ,  Makoto KAMATA ,  Takuto KOJIMA ,  Ikuo FUJIMORI ,  Kenichiro SHIMOKAWA

    IPC: C07D487/04 ,  C07D405/14

    CPC classification number: C07D487/04 ,  C07D209/46 ,  C07D401/06 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/14 ,  C07D519/00

    Abstract: Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.

    Abstract translation: 提供具有胆碱能毒蕈碱M1受体阳性变构调节剂活性的化合物，可用作阿尔茨海默病，精神分裂症，疼痛，睡眠障碍等的预防或治疗药物。 本发明涉及由下式表示的化合物：其中环A是任选具有取代基的4-至7-元环; L是-O - ， - S - ， - SO-或-SO 2 - ; R1是任选具有取代基的C 1-6烷基（条件是当L是-O-，R 1不是被卤素原子任意取代的C 1-6烷基时）或任选具有取代基的环状基团 （s）; X1为-CRa =或-N =; X2为-CRb =或-N =; X3是-CRc =或-N=; R a，R b和R c各自为任选具有取代基的C 1-6烷基，C 2-6烯基，C 1-6烷氧基，C 3-6环烷基，C 3-6环烷氧基或C 6-14芳基， H或卤素，或其盐。

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