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公开(公告)号：US20190119225A1
公开(公告)日：2019-04-25
申请号：US16230634
申请日：2018-12-21
IPC分类号： C07D263/46 , C07D213/70 , A61P27/02 , C07D239/34 , A61K31/421 , C07D213/65 , C07D263/38 , A61K31/415 , C07D231/22 , C07D231/12 , A61K31/505 , A61K31/4418
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
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公开(公告)号：US10975043B2
公开(公告)日：2021-04-13
申请号：US16773720
申请日：2020-01-27
IPC分类号： A61K31/4418 , A61K31/505 , C07D239/34 , C07D213/65 , C07D213/70 , C07D263/46 , A61K31/415 , A61K31/421 , C07D231/12 , C07D231/22 , C07D263/38 , A61P27/02 , C07K14/47 , C12N15/09
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.-
公开(公告)号：US09975903B2
公开(公告)日：2018-05-22
申请号：US15539607
申请日：2015-12-24
发明人： Minoru Sasaki , Fumiaki Kikuchi , Zenichi Ikeda , Keiko Kakegawa , Yoichi Nishikawa , Shigekazu Sasaki , Koichiro Fukuda , Kazuaki Takami , Yoshihiro Banno , Masahiro Kamaura
IPC分类号： C07D493/04 , C07D495/04 , C07D321/00 , C07D405/06 , C07D321/12 , C07D413/06 , C07D323/00 , C07D491/044 , C07D313/00 , C07D313/20
CPC分类号： C07D495/04 , A61K31/365 , A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/662 , C07D313/00 , C07D313/20 , C07D321/00 , C07D321/12 , C07D323/00 , C07D405/06 , C07D409/12 , C07D413/06 , C07D491/044 , C07D493/04 , C07F9/655
摘要： The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].
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公开(公告)号：US09944596B2
公开(公告)日：2018-04-17
申请号：US15518782
申请日：2015-10-22
发明人： Yoshihiro Banno , Masahiro Kamaura , Takahiko Taniguchi , Kazuaki Takami , Koichiro Fukuda , Shigekazu Sasaki
IPC分类号： C07D207/08 , A61K31/401
CPC分类号： C07D207/08 , A61K31/40 , A61K31/401 , C12N15/09
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
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公开(公告)号：US20200157062A1
公开(公告)日：2020-05-21
申请号：US16773720
申请日：2020-01-27
IPC分类号： C07D263/46 , C07D213/70 , A61P27/02 , C07D213/65 , C07D263/38 , C07D239/34 , C07D231/22 , C07D231/12 , A61K31/505 , A61K31/4418 , A61K31/421 , A61K31/415
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
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公开(公告)号：US10214498B2
公开(公告)日：2019-02-26
申请号：US15517227
申请日：2015-10-22
IPC分类号： A61P27/02 , C07K14/47 , C12N15/09 , A61K31/415 , A61K31/505 , C07D213/65 , C07D213/70 , C07D231/12 , C07D231/22 , C07D239/34 , A61K31/4418 , A61K31/421 , C07D263/38 , C07D263/46
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
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公开(公告)号：US09487509B2
公开(公告)日：2016-11-08
申请号：US14055585
申请日：2013-10-16
发明人： Shizuo Kasai , Tomohiro Kaku , Masahiro Kamaura
IPC分类号： C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/78 , C07D211/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/04 , C07D417/06 , C07D413/08 , C07D417/04 , C07D417/08 , C07D417/10 , C07D471/04 , C07D495/04 , C07D513/04
CPC分类号： C07D417/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/78 , C07D211/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/08 , C07D417/10 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.
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公开(公告)号：US20210340114A1
公开(公告)日：2021-11-04
申请号：US17226854
申请日：2021-04-09
IPC分类号： C07D263/46 , A61K31/4418 , A61P27/02 , A61K31/421 , C07D231/22 , C07D239/34 , A61K31/505 , C07D263/38 , C07D213/70 , C07D213/65 , C07D231/12 , A61K31/415 , C07K14/47 , C12N15/09
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.-
公开(公告)号：US10544111B2
公开(公告)日：2020-01-28
申请号：US16230634
申请日：2018-12-21
IPC分类号： C07D263/46 , A61K31/415 , A61K31/421 , A61K31/4418 , A61K31/505 , C07D231/12 , C07D231/22 , C07D239/34 , C07D263/38 , C07D213/65 , A61P27/02 , C07D213/70 , C07K14/47 , C12N15/09
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
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