公开(公告)号：US20190106437A1

公开(公告)日：2019-04-11

申请号：US16094030

申请日：2017-04-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Youichi KAWAKITA ,  Takuto KOJIMA ,  Noriyuki NII ,  Yoshiteru ITO ,  Nobuki SAKAUCHI ,  Hiroshi BANNO ,  Xin LIU ,  Koji ONO ,  Keisuke IMAMURA ,  Shinichi IMAMURA

IPC: C07D519/00 ,  A61P35/00

Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].

公开(公告)号：US20250034141A1

公开(公告)日：2025-01-30

申请号：US18908457

申请日：2024-10-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takaharu HIRAYAMA ,  Yoshiteru ITO ,  Noriyuki NII ,  Youichi KAWAKITA ,  Shinichi IMAMURA

IPC: C07D471/04 ,  C07D487/04

Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

公开(公告)号：US20180079723A1

公开(公告)日：2018-03-22

申请号：US15563128

申请日：2016-03-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Ryo Mizojiri ,  Moriteru ASANO ,  Daisuke TOMITA ,  Hiroshi BANNO ,  Michiko TAWADA ,  Noriyuki NII ,  Krista E. GIPSON ,  Hironobu MAEZAKI ,  Shuntaro TSUCHIYA ,  Mayumi IMAI ,  Yuichiro AMANO

IPC: C07D213/65 ,  C07C233/25 ,  C07D401/12 ,  C07C255/54 ,  C07D213/69 ,  C07C233/18 ,  C07D263/42 ,  C07D263/32 ,  C07D413/04 ,  C07D239/34 ,  C07D241/18 ,  C07D277/34 ,  C07D231/12 ,  C07D207/12 ,  C07D261/08 ,  C07D417/04 ,  C07D237/14 ,  C07D211/46 ,  C07D213/74 ,  C07D213/81

CPC classification number: C07D213/65 ,  A61K31/165 ,  A61K31/167 ,  A61K31/277 ,  A61K31/381 ,  A61K31/402 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  C07C233/18 ,  C07C233/25 ,  C07C233/47 ,  C07C255/54 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/08 ,  C07D207/12 ,  C07D211/44 ,  C07D211/46 ,  C07D213/643 ,  C07D213/69 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D231/12 ,  C07D237/14 ,  C07D239/34 ,  C07D241/18 ,  C07D261/08 ,  C07D263/32 ,  C07D263/42 ,  C07D277/34 ,  C07D333/20 ,  C07D401/04 ,  C07D401/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C12N9/99 ,  C12N15/09

Abstract: The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.

公开(公告)号：US20210115067A1

公开(公告)日：2021-04-22

申请号：US17130297

申请日：2020-12-22

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Youichi KAWAKITA ,  Takuto KOJIMA ,  Noriyuki NII ,  Yoshiteru ITO ,  Nobuki SAKAUCHI ,  Hiroshi BANNO ,  Xin LIU ,  Koji ONO ,  Keisuke IMAMURA ,  Shinichi IMAMURA

IPC: C07D519/00 ,  A61K31/444 ,  A61K31/53 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/4985 ,  A61P35/00

Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].

公开(公告)号：US20170015654A1

公开(公告)日：2017-01-19

申请号：US15124932

申请日：2015-03-11

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Keisuke IMAMURA ,  Naoki TOMITA ,  Yoshiteru ITO ,  Koji ONO ,  Hironobu MAEZAKI ,  Noriyuki NII

IPC: C07D413/14 ,  C07D417/14 ,  C07D403/14 ,  C07D413/04 ,  C07D401/14

CPC classification number: C07D413/14 ,  A61K9/0019 ,  A61K9/1617 ,  A61K9/19 ,  A61K9/2013 ,  C07D401/14 ,  C07D403/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present provides a pyridazine compound having an inhibiting effect on Stearoyl-CoA desaturase (SCD) (in particular, SCD1). The present provides a compound represented by formula (where each symbol is as defined as in the Specification) or a salt thereof.

Abstract translation: （其中每个符号如本说明书中所定义）或其盐。