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    Methods for multi-dose synthesis of [F-18]FDDNP for clinical settings
    1.
    发明授权
    Methods for multi-dose synthesis of [F-18]FDDNP for clinical settings 有权

    公开(公告)号：US10377701B2

    公开(公告)日：2019-08-13

    申请号：US15807306

    申请日：2017-11-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Nagichettiar Satyamurthy ,  Jie Liu ,  Jorge R. Barrio

    IPC: C07C253/30 ,  C07B59/00 ,  C07C253/34 ,  C07C255/34

    Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.

    MODULAR RADIOCHEMISTRY SYNTHESIS SYSTEM
    3.
    发明申请
    MODULAR RADIOCHEMISTRY SYNTHESIS SYSTEM 有权
    模块化放射化学合成系统

    公开(公告)号：US20150329583A1

    公开(公告)日：2015-11-19

    申请号：US14582885

    申请日：2014-12-24

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

    IPC: C07H19/16 ,  B01J19/00 ,  C07D207/46 ,  C07C205/12 ,  C07H3/02 ,  B01J19/12 ,  C07H19/06

    CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

    Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

    Abstract translation: 模块化化学生产系统包括从远程位置进行化学反应，特别是放射化学化合物的多个模块。 一个实施例包括一个包括可移动热源的反应容器，其相对于反应容器的位置可从远程位置控制。 或者，热源可以固定在位置，并且反应小瓶可移动进入和离开热源。 反应容器具有一个或多个密封塞，其与反应容器相关的定位可从远程位置控制。 此外，一个或多个反应容器密封塞可以包括一个或多个管道，用于输送反应物，大气压或高压气体，惰性气体，抽真空和从反应小瓶中除去反应终产物， 具有密封塞位置的反应小瓶可在升高的压力下操作。 模块化化学生产系统由模块组装，每个模块可以包括操作状态传感器和配置成用于从远程位置监控和控制各个模块和组装系统的控制器。 其他模块包括但不限于试剂储存和输送模块，滤芯净化模块，微波反应模块，外部QC /分析/纯化界面模块，等分模块，F-18干燥模块，浓缩模块 ，辐射计数模块和毛细管反应堆模块。

    Modular radiochemistry synthesis system
    4.
    发明授权
    Modular radiochemistry synthesis system 有权
    模块放射化学合成系统

    公开(公告)号：US09211520B2

    公开(公告)日：2015-12-15

    申请号：US14582885

    申请日：2014-12-24

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

    IPC: G01N31/00 ,  B01J19/12 ,  B01J19/00

    CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

    Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

    Abstract translation: 模块化化学生产系统包括从远程位置进行化学反应，特别是放射化学化合物的多个模块。 一个实施例包括一个包括可移动热源的反应容器，其相对于反应容器的位置可从远程位置控制。 或者，热源可以固定在位置，并且反应小瓶可移动进入和离开热源。 反应容器具有一个或多个密封塞，其与反应容器相关的定位可从远程位置控制。 此外，一个或多个反应容器密封塞可以包括一个或多个管道，用于输送反应物，大气压或高压气体，惰性气体，抽真空和从反应小瓶中除去反应终产物， 具有密封塞位置的反应小瓶可在升高的压力下操作。 模块化化学生产系统由模块组装，每个模块可以包括操作状态传感器和配置成用于从远程位置监控和控制各个模块和组装系统的控制器。 其他模块包括但不限于试剂储存和输送模块，滤芯净化模块，微波反应模块，外部QC /分析/纯化界面模块，等分模块，F-18干燥模块，浓缩模块 ，辐射计数模块和毛细管反应堆模块。

    METHODS FOR MULTI-DOSE SYNTHESIS OF [F-18]FDDNP FOR CLINICAL SETTINGS
    5.
    发明申请
    METHODS FOR MULTI-DOSE SYNTHESIS OF [F-18]FDDNP FOR CLINICAL SETTINGS 审中-公开

    公开(公告)号：US20190322616A1

    公开(公告)日：2019-10-24

    申请号：US16457322

    申请日：2019-06-28

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Nagichettiar Satyamurthy ,  Jie Liu ,  Jorge R. Barrio

    IPC: C07C253/30 ,  C07C255/34 ,  C07C253/34 ,  C07B59/00

    Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.

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