公开(公告)号：US12012467B2

公开(公告)日：2024-06-18

申请号：US16496974

申请日：2018-03-28

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Haibin Zhou ,  Jianfeng Lu ,  Liu Liu ,  Yi Sun ,  Denzil Bernard

IPC: A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/454 ,  A61K31/5377 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07D277/30 ,  C07D277/64 ,  C07D417/12 ,  C07K5/02 ,  C07K5/062 ,  C07K5/078 ,  C07K5/097 ,  C07K5/113 ,  C07K5/117 ,  C07K7/02

CPC classification number: C07K5/1021 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/454 ,  A61K31/5377 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07D277/30 ,  C07D277/64 ,  C07D417/12 ,  C07K5/02 ,  C07K5/021 ,  C07K5/06026 ,  C07K5/06139 ,  C07K5/0821 ,  C07K5/1024 ,  C07K7/02

Abstract: Compounds of formula (I) as inhibitors of DCN1 and compositions containing the same are disclosed. Methods of using the DCN1 inhibitors in the treatment of diseases and conditions wherein inhibition of DCN1 provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.

公开(公告)号：US20230218765A1

公开(公告)日：2023-07-13

申请号：US17924794

申请日：2021-05-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Mingliang Wang ,  Jianfeng Lu ,  Mi Wang

IPC: A61K47/54 ,  A61K47/55 ,  A61P35/00

CPC classification number: A61K47/545 ,  A61K47/55 ,  A61P35/00

Abstract: The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein R1, R3, L, Y, and B1 are as defined in the specification. Compounds having Formula I are SHP2 protein degraders useful for the treatment of cancer and other diseases.

公开(公告)号：US20250034162A1

公开(公告)日：2025-01-30

申请号：US18887703

申请日：2024-09-17

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Rohan Rej ,  Changwei Wang ,  Mi Wang ,  Jianfeng Lu ,  Chao-Yie Yang ,  Ester Fernandez-Salas ,  Jeanne Stuckey

IPC: C07D491/22 ,  A61K45/06 ,  A61P35/00 ,  C07D471/22 ,  C07D487/04 ,  C07D487/14 ,  C07D495/14 ,  C07D495/22 ,  C07D498/22 ,  C07D513/22 ,  C07F9/6561

Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.

公开(公告)号：US20240190880A1

公开(公告)日：2024-06-13

申请号：US18279236

申请日：2022-03-04

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Zhixiang Chen ,  Rohan Rej ,  Dimin Wu ,  Jianfeng Lu ,  Biao Hu ,  Mingliang Wang ,  Ranjan Kumar Acharyya

IPC: C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X, J, Y, Z, n, and B 1 are as defined as set forth in the specification. The present disclosure also relates to uses of the compounds, e.g., in treating preventing a condition or disorder responsive to the degradation of estrogen receptor protein (e.g., cancer).

公开(公告)号：US20220227778A1

公开(公告)日：2022-07-21

申请号：US16971472

申请日：2020-07-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Rohan Rej ,  Changwei Wang ,  Mi Wang ,  Jianfeng Lu ,  Chao-Yie Yang ,  Ester Fernandez-Salas ,  Jeanne Stuckey

IPC: C07D491/22 ,  C07D487/14 ,  C07D471/22 ,  C07D495/14 ,  C07D495/22 ,  C07D513/22 ,  C07D487/04 ,  C07F9/6561 ,  C07D498/22 ,  A61P35/00 ,  A61K45/06

Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.

公开(公告)号：US20150299211A1

公开(公告)日：2015-10-22

申请号：US14688553

申请日：2015-04-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Angelo Aguilar ,  Liu Liu ,  Jianfeng Lu ,  Donna McEachern

IPC: C07D487/10 ,  A61K45/06 ,  A61N5/10 ,  A61K31/407

CPC classification number: C07D487/10 ,  A61K31/407 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098

Abstract: Inhibitors of MDM2 and MDM2-related proteins and compositions containing the same are disclosed. Methods of using the MDM2 inhibitors in the treatment of diseases and conditions wherein inhibition of an interaction between p53 and MDM2 provides a benefit, like cancers, also are disclosed.

Abstract translation: 公开了MDM2和MDM2相关蛋白的抑制剂和含有它们的组合物。 还公开了使用MDM2抑制剂治疗其中抑制p53和MDM2之间的相互作用提供益处的疾病和病症的方法，如癌症。

公开(公告)号：US20220380368A1

公开(公告)日：2022-12-01

申请号：US17760786

申请日：2020-09-18

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Xin Han ,  Weiguo Xiang ,  Bukeyan Miao ,  Chong Qin ,  Lijie Zhao ,  Jianfeng Lu ,  Tianfeng Xu ,  Chao-Yie Yang

IPC: C07D471/10 ,  A61P35/00 ,  A61P13/08

Abstract: The present disclosure provides compounds represented by Formula (I) and the salts or solvates thereof, wherein R3a, E, L, A1, B1, X1, X2, Z1, and Z2 are as defined in the specification. Compounds having Formula (I) are androgen receptor degraders useful for the treatment of cancer and other diseases.

公开(公告)号：US20180289677A1

公开(公告)日：2018-10-11

申请号：US15949799

申请日：2018-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Haibin Zhou ,  Jianfeng Lu ,  Liu Liu ,  Jeanne Stuckey ,  Liangyou Rui ,  Yi Sun

IPC: A61K31/428 ,  A61P1/16

Abstract: Small molecule covalent inhibitors of DCN1 and compositions containing the same are disclosed. Methods of using the DCN1 covalent inhibitors in the treatment of diseases and conditions wherein inhibition of DCN1 provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.

公开(公告)号：US08883771B2

公开(公告)日：2014-11-11

申请号：US13969030

申请日：2013-08-16

Applicant: The Regents of the University of Michigan

Inventor： Shaomeng Wang ,  Rong Sheng ,  Haiying Sun ,  Liu Liu ,  Jianfeng Lu ,  Donna McEachern

IPC: C07D225/00 ,  A61K31/545 ,  C07D519/00 ,  A61K31/407 ,  A61K31/496 ,  A61K45/06

CPC classification number: C07D519/00 ,  A61K31/407 ,  A61K31/496 ,  A61K45/06

Abstract: Inhibitors of IAP proteins and compositions containing the same are disclosed. Methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP proteins provides a benefit, like cancers, also are disclosed.

Abstract translation: 公开了IAP蛋白的抑制剂和含有其的组合物。 还公开了使用IAP蛋白抑制剂治疗其中抑制IAP蛋白提供益处的疾病和病症的方法，如癌症。

公开(公告)号：US20140057924A1

公开(公告)日：2014-02-27

申请号：US13969030

申请日：2013-08-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Rong Sheng ,  Haiying Sun ,  Liu Liu ,  Jianfeng Lu ,  Donna McEachern

IPC: C07D519/00 ,  A61K31/407 ,  A61K31/496 ,  A61K45/06

CPC classification number: C07D519/00 ,  A61K31/407 ,  A61K31/496 ,  A61K45/06

Abstract: Inhibitors of IAP proteins and compositions containing the same are disclosed. Methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP proteins provides a benefit, like cancers, also are disclosed.

Abstract translation: 公开了IAP蛋白的抑制剂和含有其的组合物。 还公开了使用IAP蛋白抑制剂治疗其中抑制IAP蛋白提供益处的疾病和病症的方法，如癌症。