公开(公告)号：US20150031037A1

公开(公告)日：2015-01-29

申请号：US14340368

申请日：2014-07-24

Applicant: CapitalBio Corporation ,  Tsinghua University

Inventor： Hang LI ,  Jinglin ZHOU ,  Dong WANG

IPC: H02K7/14 ,  H02K11/00 ,  C12Q1/68 ,  H02K7/10

CPC classification number: C12Q1/686 ,  B03C1/06 ,  G01N27/745 ,  G01N35/0098

Abstract: In some aspects, the present disclosure provides a magnetic rack comprising a lateral movement structure and/or a longitudinal movement structure. In particular embodiments, the lateral movement structure and/or longitudinal movement structure move one or more magnets to or away from a reaction tube, in order to control the magnetic forces exerted on microbeads in the reaction tube. The microbeads are attracted onto the reaction tube wall, thereby facilitating separation of the microbeads from a solution in the tube. In particular embodiments, the magnetic rack is used to extract or purify nucleic acid from a sample.

Abstract translation: 在一些方面，本公开提供了一种包括横向运动结构和/或纵向运动结构的磁性架。 在特定实施例中，横向移动结构和/或纵向移动结构将一个或多个磁体移动到或远离反应管，以便控制施加在反应管中的微珠上的磁力。 微珠被吸引到反应管壁上，从而有助于将微珠与管中的溶液分离。 在具体实施方案中，磁性架用于从样品中提取或纯化核酸。

公开(公告)号：US20170164830A1

公开(公告)日：2017-06-15

申请号：US15374818

申请日：2016-12-09

Applicant: CAPITALBIO EHEALTH SCIENCE & TECHNOLOGY (BEIJING) CO., LTD. ,  CapitalBio Corporation ,  Tsinghua University

Inventor： Guoliang HUANG ,  Wenjun WANG ,  Hongmei CAO ,  Lili ZHANG ,  Li MA ,  Chengjin ZHANG ,  Yimin SUN ,  Dong WANG ,  Jing CHENG

IPC: A61B3/15 ,  G06K9/00 ,  G06F17/30 ,  G06K9/46 ,  G06T7/13 ,  A61B3/00 ,  G06T7/00

CPC classification number: A61B3/156 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/0083 ,  A61B3/0091 ,  G06F17/30256 ,  G06F17/3028 ,  G06K9/00604 ,  G06K9/0061 ,  G06K9/00617 ,  G06K9/4604 ,  G06K2209/05 ,  G06T7/0012 ,  G06T7/0014 ,  G06T7/13 ,  G06T2207/10004 ,  G06T2207/10024 ,  G06T2207/30041

Abstract: In one aspect, disclosed herein are devices, systems, and methods for assessing human health states based on non-shadow imaging of sclera, or whites, of one or both eyes. In one aspect, the device is an on-body device. In one aspect, the system comprises a positioning aperture, an illuminating apparatus, an imaging apparatus, and/or a processing apparatus. In one aspect, the process only takes a short period of time to take images of the sclera without any operation of splicing multiple images. In one aspect, the device or system improves the quality of images by avoiding the formation of reflection of the illuminating apparatus on the images of the sclera. In a further aspect, the system can utilize the sclera images to obtain information of eye diseases and to predict the physiological and pathological changes in the health status of subject or diagnostic results, which can provide helpful information for medical diagnosis.

公开(公告)号：US20190224663A1

公开(公告)日：2019-07-25

申请号：US16332984

申请日：2017-09-28

Applicant: TSINGHUA UNIVERSITY

Inventor： Junhua LI ,  Lina GAN ,  Yue PENG ,  Shuangjiang YU ,  Dong WANG ,  Jianjun CHEN

IPC: B01J37/08 ,  B01J23/22 ,  B01J23/30 ,  B01J23/00 ,  B01J37/00

Abstract: The invention discloses a preparation method and application of a denitration catalyst with wide operating temperature for flue gas, which utilizes an organic vanadium compound as a vanadium precursor, and titanium dioxide powder or titanium tungsten powder as a carrier, and is prepared by mechanical ball milling method and heat treatment to obtain a catalyst, which denitration of fixed source flue gas under wide temperature range. Compared with the existing arts, the present invention includes minor modifications to the traditional vanadium tungsten titanium catalyst system and adopts the mechanical ball milling method, the activity and resistance to sulfur and water poisoning are improved significantly, thus providing a preparation technology of SCR denitration powder catalyst which is green, highly efficient, low cost and simple in operation. Through the interaction of the organic vanadium precursor with the carrier, the vanadium surface atom concentration of the catalyst is higher, the species of polymeric vanadium is more, and the vanadium oxide is more easily reduced, thereby obtaining higher denitrification activity at low temperature. The denitration catalyst of the present invention has relatively higher activity at 200-450° C. while having good resistance to sulfur and water poisoning.

公开(公告)号：US20190085393A1

公开(公告)日：2019-03-21

申请号：US15525037

申请日：2015-11-10

Applicant: CapitalBio Corporation ,  Tsinghua University

Inventor： Dong WANG ,  Hui WANG ,  Yan ZHANG ,  Guangxin XIANG ,  Yimin SUN ,  Wanli XING ,  Jing CHENG

IPC: C12Q1/6876 ,  C12Q1/6853 ,  C12Q1/6869

Abstract: Provided herein is a multi-sample and multi-locus method for analyzing a genetic locus. In particular, provided herein is a method for SNP detection and analysis based on high-throughput sequencing, comprising designing a probe, pre-amplification and biotin labeling, hybridization, ligation, barcode specific primer extension, sequencing and analyzing the SNP locus. A probe set is for the analysis is also provided.

公开(公告)号：US20160231223A1

公开(公告)日：2016-08-11

申请号：US15019715

申请日：2016-02-09

Applicant: CapitalBio Corporation ,  Tsinghua University

Inventor： Dong WANG ,  Zhen CHENG ,  Danyang MEI ,  Dongliang AN ,  Wei YANG ,  Xiaokun QIN

IPC: G01N15/14 ,  B01L3/00

CPC classification number: G01N15/1404 ,  B01L3/5027 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2400/0439 ,  B07C5/02 ,  B07C5/342 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/142 ,  G01N2015/149

Abstract: The present disclosure in some embodiments provides a flow cell sorting system, a focus detection method, as well as a fluidic chip. In one aspect, the fluidic chip comprises a cover sheet and one or more substrate layers, and one or more channels in each of the fluidic chips. In one aspect, the cells or other analytes in a sample are focused onto the same plane as they flow through the fluidic channel. In another aspect, the cells or other analytes on the same plane are irradiated with the same light intensity, for example, by a flat-top laser beam. This combination eliminates or reduces variation caused by cells at different positions receiving different intensities of the excitation light, and therefore improves accuracy of the flow cytometry analysis. In another aspect, a sorting apparatus is designed at the junction of the detection area and the outlet channel to separate the target cells.

Abstract translation: 在一些实施例中的本公开提供了流动池分选系统，焦点检测方法以及流体芯片。 一方面，流体芯片包括覆盖片和一个或多个衬底层，以及每个流体碎片中的一个或多个通道。 在一个方面，样品中的细胞或其他分析物在流过流体通道时聚焦在相同的平面上。 在另一方面，例如通过平顶激光束以相同的光强照射同一平面上的细胞或其它分析物。 该组合消除或减少了在接收不同激发光强度的不同位置处由细胞引起的变化，因此提高了流式细胞术分析的准确性。 在另一方面，在检测区域和出口通道的连接处设计分选装置以分离靶细胞。