公开(公告)号：US06699880B1

公开(公告)日：2004-03-02

申请号：US10110638

申请日：2002-04-15

申请人： Takeru Yamakawa ,  Makoto Ando ,  Seita Koito ,  Kenji Ohwaki ,  Toshifumi Kimura ,  Toshihiko Saeki ,  Mitsuru Miyaji ,  Yuki Iwahori ,  Toru Fujikawa ,  Norikazu Otake ,  Kazuhito Noguchi

发明人： Takeru Yamakawa ,  Makoto Ando ,  Seita Koito ,  Kenji Ohwaki ,  Toshifumi Kimura ,  Toshihiko Saeki ,  Mitsuru Miyaji ,  Yuki Iwahori ,  Toru Fujikawa ,  Norikazu Otake ,  Kazuhito Noguchi

IPC分类号： A61K31445

CPC分类号： C07D401/14

摘要： This invention relates to the compounds represented by the general formula [I], [in which A—D signify optionally substituted methine group(s) or nitrogen atom; E signifies oxygen or sulfur atom; signify optionally substituted mono- or bi-cyclic aliphatic nitrogen-containing heterocyclic group(s); R1 signifies lower alkenyl, lower alkynyl, cyclo(lower alkyl), lower alkanoyl, lower alkoxycarbonyl, optionally substituted lower alkyl and the like; and R2 signifies lower alkyl]. The compounds of the present invention exhibit an action to stimulate muscarinic acetylcholine receptors M4, and are useful as analgesic for diseases accompanying pain such as cancerous pain, migraine, gout, chronic rheumatism, chronic pain or neuralgia; or as agents for treating tolerance to narcotic analgesics represented by morphine, dependence on narcotic analgesics represented by morphine, itching, dementia, irritable bowel syndrome, schizophrenia, glaucoma, pollakiuria, urinary incontinence, cholelithiasis, cholecystitis, functional dyspepsia and reflux esophagitis.

摘要翻译： 本发明涉及由通式[I]表示的化合物，其中A-D表示任选取代的次甲基或氮原子; E表示氧或硫原子;表示任选取代的单环或双环脂族含氮杂环基; R 1表示低级烯基，低级炔基，环（低级烷基），低级烷酰基，低级烷氧基羰基，任意取代的低级烷基等; 本发明化合物表现出刺激毒蕈碱性乙酰胆碱受体M4的作用，可作为镇痛药用于伴随疼痛的疾病，例如癌性疼痛，偏头痛，痛风，慢性风湿病，慢性疼痛或慢性疼痛。 神经痛; 或作为治疗由吗啡代表的麻醉止痛药的耐受性的药剂，以吗啡，瘙痒，痴呆，肠易激综合征，精神分裂症，青光眼，尿频尿症，尿失禁，胆石病，胆囊炎，功能性消化不良和反流性食管炎为代表的麻醉止痛药的依赖。

公开(公告)号：US07452908B2

公开(公告)日：2008-11-18

申请号：US10838340

申请日：2004-05-05

申请人： Yufu Sagara ,  Minaho Uchiyama ,  Akira Naya ,  Toshifumi Kimura ,  Tomoshige Numazawa ,  Toru Fujikawa ,  Norikazu Otake ,  Kazuhito Noguchi

发明人： Yufu Sagara ,  Minaho Uchiyama ,  Akira Naya ,  Toshifumi Kimura ,  Tomoshige Numazawa ,  Toru Fujikawa ,  Norikazu Otake ,  Kazuhito Noguchi

IPC分类号： A61K31/445 ,  C07D211/32

CPC分类号： C07D401/12 ,  C07D207/16 ,  C07D211/26 ,  C07D401/14 ,  C07D471/10 ,  C07D493/10

摘要： This invention relates to compounds which are represented by the general formula [I] [in which A stands for a group of the following formula [ao] or [b0] Ar1, Ar2 and Ar3 stand for optionally substituted phenyl; k stands for 0 or 1; m, n and s stand for 0, 1 or 2; R1 stands for hydrogen or optionally substituted lower alkyl; R2, R3, R4 and R5 either stand for hydrogen or optionally substituted lower alkyl, or R2 and R3, or R4 and R5 together stand for trimethylene and the like; R60 stands for hydrogen, alkyl, or the like; R61 and R71 either stand for alkyl and the like, or together stand for trimethylene and the like; X stands for carbonyl or methylene; Y stands for nitrogen or methine; and Q− stands for anion], and the like. The compounds of the invention exhibit selective antagonism to muscarinic M3 receptors, and therefore are useful as safe and effective agents showing little side effect, for treating diseases of the respiratory, urinary and digestive systems.

摘要翻译： 本发明涉及由通式[I]表示的化合物[其中A代表下列通式[a]或[b] 0 Ar 1，Ar 2和Ar 3代表任选取代的苯基; k代表0或1; m，n和s代表0,1或2; R 1表示氢或任选取代的低级烷基; R 2，R 3，R 4和R 5均代表氢或任选取代的低级烷基，或 R 2和R 3，或R 4和R 5一起代表三亚甲基等; R 60代表氢，烷基等; R 61和R 71均代表烷基等，或一起代表三亚甲基等; X代表羰基或亚甲基; Y代表氮或次甲基; 和Q ^{代表阴离子]等。 本发明的化合物对毒蕈碱M 3受体表现出选择性拮抗作用，因此可用作治疗呼吸，泌尿和消化系统疾病的副作用小的安全有效的药剂。}

公开(公告)号：US06809108B1

公开(公告)日：2004-10-26

申请号：US10031716

申请日：2002-03-26

申请人： Yufu Sagara ,  Minaho Uchiyama ,  Akira Naya ,  Toshifumi Kimura ,  Tomoshige Numazawa ,  Toru Fujikawa ,  Norikazu Otake ,  Kazuhito Noguchi

发明人： Yufu Sagara ,  Minaho Uchiyama ,  Akira Naya ,  Toshifumi Kimura ,  Tomoshige Numazawa ,  Toru Fujikawa ,  Norikazu Otake ,  Kazuhito Noguchi

IPC分类号： A61K31445

CPC分类号： C07D401/12 ,  C07D207/16 ,  C07D211/26 ,  C07D401/14 ,  C07D471/10 ,  C07D493/10

摘要： This invention relates to compounds which are represented by the general formula [I] [in which A stands for a group of the following formula [a0] or [b0] Ar1, Ar2 and Ar3 stand for optionally substituted phenyl; k stands for 0 or 1; m, n and a stand for 0, 1 or 2; R1 stands for hydrogen or optionally substituted lower alkyl; R2, R3, R4 and R5 either stand for hydrogen or optionally substituted lower alkyl, or R2 and R3, or R4 and R5 together stand for trimethylene and the like; R60 stands for hydrogen, alkyl, or the like; R61 and R71 either stand for alkyl and the like, or together stand for trimethylene and the like; X stands for carbonyl or methylene; Y stands for nitrogen or methine; and Q− stands for anion], and the like. The compounds of the invention exhibit selective antagonism to muscarinic M3 receptors, and therefore are useful as safe and effective agents showing little side effect, for treating diseases of the respiratory, urinary and digestive systems.

摘要翻译： 本发明涉及由通式[I]表示的化合物[其中A代表下式[a0]或[b0] Ar 1的基团，Ar 2和Ar 3代表 任选取代的苯基; k代表0或1; m，n和a代表0,1或2; R 1代表氢或任选取代的低级烷基; R 2，R 3，R 4和R 5分别代表氢或任选取代的低级烷基，或者R 2和R 3，或R 4和R 5， 一起代表三亚甲基等; R 60代表氢，烷基等; R 61和R 71代表烷基等，或一起代表三亚甲基等; X代表羰基或亚甲基; Y代表氮或次甲基; 并且Q 1表示阴离子]等。本发明的化合物对毒蕈碱性M3受体表现出选择性拮抗作用，因此可用作治疗副作用小的安全有效药物，用于治疗呼吸道，尿和尿的疾病 消化系统。

公开(公告)号：US5163389A

公开(公告)日：1992-11-17

申请号：US858497

申请日：1992-03-27

申请人： Toru Fujikawa ,  Yasuhiro Kobayashi ,  Tadashi Terazawa

发明人： Toru Fujikawa ,  Yasuhiro Kobayashi ,  Tadashi Terazawa

IPC分类号： F01L1/24 ,  F01L13/00

CPC分类号： F01L13/0005

摘要： A hydraulic valve lifter having function to stop valve drive comprises a cylinder, a lifter body sliding in the cylinder, a cam driving the lifter body, a tappet sliding in the lifter body, a valve driven by the tappet, a plunger located between the lifter body and the tappet, a reservoir formed in the lifter body and being in fluid communication with a hydraulic source always, a first pressure room formed in the tappet and separated from the reservoir via the plunger, a check valve controlling a communication between the reservoir and the first pressure room, a piston sliding in the lifter body and having a rod driving the check valve, a second pressure room located at one side of the piston and being in fluid communication with the hydraulic source via a control valve, a room located at the other side of the piston, and a passage decreasing a pressure in the room.

摘要翻译： 具有停止阀驱动功能的液压气门挺杆包括气缸，在气缸内滑动的升降机体，驱动升降机体的凸轮，升降机主体中滑动的挺杆，由挺杆驱动的阀，位于升降器之间的柱塞 主体和挺杆，形成在升降机主体中并且与液压源流体连通的储存器，形成在挺杆中的第一压力室并且经由柱塞与储存器分离;止回阀，其控制储存器和 所述第一压力室，在所述升降机主体中滑动并具有驱动所述止回阀的杆的活塞，位于所述活塞的一侧并且经由控制阀与所述液压源流体连通的第二压力室，位于 活塞的另一侧，以及减小房间内的压力的通道。

公开(公告)号：US06189507B1

公开(公告)日：2001-02-20

申请号：US09316124

申请日：1999-05-20

申请人： Hideki Tsuchiya ,  Toru Fujikawa

发明人： Hideki Tsuchiya ,  Toru Fujikawa

IPC分类号： F02D4100

CPC分类号： F02D11/105 ,  F02D9/1065 ,  F02D2009/0261

摘要： A throttle valve control device for controlling the amount of inlet air fed to an internal combustion engine has a throttle valve disposed in an air intake passage, a throttle shaft integrally connected with the throttle valve so as to rotate with the throttle valve in a body, a driving source for generating driving torque, and a driving torque transmitting mechanism disposed between the driving source and the throttle shaft for transmitting the driving torque to the throttle shaft. The driving torque transmitting mechanism includes a torque limiting mechanism for limiting the transmitted driving torque to a predetermined level.

摘要翻译： 用于控制供给内燃机的入口空气量的节流阀控制装置具有设置在进气通道中的节流阀，与节气门一体地连接的节流阀，以便与节气门一起旋转， 用于产生驱动扭矩的驱动源，以及设置在驱动源和节流轴之间的驱动扭矩传递机构，用于将驱动扭矩传递到节流轴。 驱动扭矩传递机构包括用于将传递的驱动转矩限制到预定水平的扭矩限制机构。

公开(公告)号：US5163402A

公开(公告)日：1992-11-17

申请号：US813503

申请日：1991-12-26

申请人： Yoshinori Taguchi ,  Yukihisa Oda ,  Tokihiko Akita ,  Masaru Shimizu ,  Toru Fujikawa

发明人： Yoshinori Taguchi ,  Yukihisa Oda ,  Tokihiko Akita ,  Masaru Shimizu ,  Toru Fujikawa

IPC分类号： F02D9/02 ,  F02D11/04 ,  F02D11/10 ,  F02D41/22

CPC分类号： F02D11/107 ,  F02D2011/102

摘要： A throttle control apparatus includes an accelerator operation mechanism, a throttle shaft, a driving source, an electromagnetic clutch mechanism, driving control means, accelerator operational amount detecting means, accelerator abnormality detecting means, throttle valve opening amount detecting means, throttle abnormality detecting means, valve abnormality detecting means and clutch control means. The accelerator abnormality detecting means judge the abnormality of the accelerator operational amount detecting means and the throttle abnormality detecting means judge the abnormality of the throttle valve opening amount detecting means. Furthermore, the valve abnormality detecting means judge the operation of the throttle control as abnormality when the amount of the throttle valve opening is more than a prescribed value under the condition which the operational amount of the accelerator operation amount is less than a prescribed value. As a result of abnormality judgments of these three kinds, when at least one of them is judged as abnormality, the electromagnetic clutch mechanism is driven by the clutch control means so as to separate the driving source from the throttle shaft.

摘要翻译： 节气门控制装置包括加速器操作机构，节气门轴，驱动源，电磁离合器机构，驱动控制装置，加速器操作量检测装置，加速器异常检测装置，节气门开度检测装置，节气门异常检测装置， 阀异常检测装置和离合器控制装置。 加速器异常检测装置判断加速器操作量检测装置的异常，并且节气门异常检测装置判断节气门开度检测装置的异常。 此外，在加速器操作量的操作量小于规定值的条件下，阀门异常检测装置判断节气门控制的操作是当节气门开度大于规定值时的异常。 作为这三种异常判断的结果，当至少其中一个被判断为异常时，电磁离合器机构由离合器控制装置驱动，从而将驱动源与节流轴分离。

公开(公告)号：US20110180738A1

公开(公告)日：2011-07-28

申请号：US13120280

申请日：2009-12-07

申请人： Yoshikuni Ito ,  Toru Fujikawa

发明人： Yoshikuni Ito ,  Toru Fujikawa

IPC分类号： F16K5/00

CPC分类号： F16K11/0853 ,  F16K31/043 ,  F16K31/047 ,  Y10T137/86871

摘要： A rotary valve apparatus includes a casing having a fluid passageway, a rotor rotatably mounted in the casing and configured to control, by rotation thereof, a flow state of fluid flowing in the fluid passageway, a drive mechanism for rotating the rotor, and a lock mechanism configured to allow transmission of a rotational force from the drive mechanism to the rotor and to inhibit rotation of the rotor under non-rotation driving state of the driving mechanism.

摘要翻译： 旋转阀装置包括具有流体通道的壳体，可旋转地安装在壳体中的构造，用于通过旋转来控制在流体通道中流动的流体的流动状态，用于旋转转子的驱动机构和锁 机构，其构造成允许从驱动机构传递到转子的旋转力，并且在驱动机构的非旋转驱动状态下禁止转子旋转。

公开(公告)号：US07287507B2

公开(公告)日：2007-10-30

申请号：US10546986

申请日：2004-02-27

申请人： Kazumasa Futamura ,  Makoto Shirai ,  Toru Fujikawa ,  Atsutoshi Ikegawa

发明人： Kazumasa Futamura ,  Makoto Shirai ,  Toru Fujikawa ,  Atsutoshi Ikegawa

IPC分类号： F01M1/02

CPC分类号： F01M11/02 ,  F01M2001/123 ,  F01M2001/126

摘要： In order to provide an engine oil supply apparatus including a second oil pump (12) which can draw in and discharge oil quickly regardless of whether or not a first oil pump (11) is driven and which does not need to be large, an engine oil supply apparatus (Y) includes a first oil pump (11) drawing oil through a first oil passage (21) from an oil holder (13) holding oil, a second oil pump (12) connected in series with the first oil pump (11) through a connection oil passage (26) and driven independently of the first oil pump (11), a first supply oil passage (23) for supplying oil to a first circulation section (41) from the first oil pump (11), and a second supply oil passage (24) for supplying oil to a second circulation section (42) from the second oil pump (12). In the engine oil supply apparatus (Y), a first oil reservoir (15) holds oil to be supplied to the second oil pump (12) and is provided independently of the oil holder (13) is provided.

摘要翻译： 为了提供一种发动机供油装置，其包括能够快速吸入和排出油的第二油泵（12），而不管第一油泵（11）是否被驱动并且不需要较大，发动机 供油装置（Y）包括：第一油泵（11），其通过来自保持油的油保持器（13）的第一油路（21）抽取油;第二油泵（12），与第一油泵 11），通过连接油路（26）独立于第一油泵（11）驱动，第一供油通道（23），用于从第一油泵（11）向第一循环段（41）供油; 以及用于从第二油泵（12）向第二循环部（42）供给油的第二供给油路（24）。 在发动机供油装置（Y）中，设置第一储油部（15），将供给第二油泵（12）的油保持为独立于油保持器（13）而设置。

公开(公告)号：US08267058B2

公开(公告)日：2012-09-18

申请号：US12602631

申请日：2008-09-08

申请人： Shigemitsu Suzuki ,  Toru Fujikawa ,  Yasutaka Miura ,  Naoto Toma

发明人： Shigemitsu Suzuki ,  Toru Fujikawa ,  Yasutaka Miura ,  Naoto Toma

IPC分类号： F01L1/34

CPC分类号： F01L1/3442 ,  F01L1/022 ,  F01L1/024 ,  F01L2001/34426 ,  F01L2001/3443 ,  F01L2001/34446 ,  F01L2001/34466 ,  F01L2001/34473 ,  F01L2001/34479 ,  F01L2001/34483 ,  F01L2800/00

摘要： A valve opening/closing timing control apparatus includes a phase displacing mechanism for displacing relative phase between a drive-side rotational member and a driven-side rotational member rotatable in unison with a cam shaft, a first pump driven by an internal combustion engine, a second pump driven by a drive source different from the internal combustion engine, a locking mechanism capable of locking the relative phase to an initial phase suitable for starting the internal combustion engine, and an urging mechanism 3 for urging the phase displacing mechanism in the advancing direction between the most retarding phase and the initial phase, a minimal urging force of the urging mechanism being set so as to override the displacing force toward the retarding phase side at the minimal pressure.

摘要翻译： 一个开阀/关闭正时控制装置，包括一个相移装置，用于使驱动侧旋转件和一个与凸轮轴一体旋转的从动侧旋转件之间相对相移，由内燃机驱动的第一泵， 由不同于内燃机的驱动源驱动的第二泵，能够将相位锁定到适于起动内燃机的初始阶段的锁定机构，以及用于在前进方向上推动相位移机构的推动机构3 在最延迟阶段和初始阶段之间，推动机构的最小推动力被设定为在最小压力下超越朝向延迟相侧的移动力。

公开(公告)号：US20100175650A1

公开(公告)日：2010-07-15

申请号：US12602631

申请日：2008-09-08

申请人： Shigemitsu Suzuki ,  Toru Fujikawa ,  Yasutaka Miura ,  Naoto Toma

发明人： Shigemitsu Suzuki ,  Toru Fujikawa ,  Yasutaka Miura ,  Naoto Toma

IPC分类号： F01L1/34

CPC分类号： F01L1/3442 ,  F01L1/022 ,  F01L1/024 ,  F01L2001/34426 ,  F01L2001/3443 ,  F01L2001/34446 ,  F01L2001/34466 ,  F01L2001/34473 ,  F01L2001/34479 ,  F01L2001/34483 ,  F01L2800/00

摘要： A valve opening/closing timing control apparatus includes a phase displacing mechanism for displacing relative phase between a drive-side rotational member and a driven-side rotational member rotatable in unison with a cam shaft, a first pump driven by an internal combustion engine, a second pump driven by a drive source different from the internal combustion engine, a locking mechanism capable of locking the relative phase to an initial phase suitable for starting the internal combustion engine, and an urging mechanism 3 for urging the phase displacing mechanism in the advancing direction between the most retarding phase and the initial phase, a minimal urging force of the urging mechanism being set so as to override the displacing force toward the retarding phase side at the minimal pressure.

摘要翻译： 一个开阀/关闭正时控制装置，包括一个相移装置，用于使驱动侧旋转件和一个与凸轮轴一体旋转的从动侧旋转件之间相对相移，由内燃机驱动的第一泵， 由不同于内燃机的驱动源驱动的第二泵，能够将相位锁定到适于起动内燃机的初始阶段的锁定机构，以及用于在前进方向上推动相位移机构的推动机构3 在最延迟阶段和初始阶段之间，推动机构的最小推动力被设定为在最小压力下超越朝向延迟相侧的移动力。