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    Rat highly sensitive to carcinogen
    3.
    发明申请
    Rat highly sensitive to carcinogen 审中-公开
    鼠对致癌物质敏感

    公开(公告)号：US20050044578A1

    公开(公告)日：2005-02-24

    申请号：US10784633

    申请日：2004-02-23

    申请人： Tomoyuki Shirai ,  Makoto Asamoto ,  Naomi Hokaiwado

    发明人： Tomoyuki Shirai ,  Makoto Asamoto ,  Naomi Hokaiwado

    IPC分类号： A01K67/027 ,  C07K14/705 ,  C12N15/09 ,  C12N15/85

    CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/705

    摘要： In order to make it possible to detect a carcinogen highly sensitively and more easily in a short time, the present invention provides a rat having a high sensitivity to a carcinogen, and a method for detecting carcinogens using the rat, and a method for screening anticancer substances using the rat made to develop a cancer. It has been found that a rat whose normal function in gap junction is inhibited has a high sensitivity to a carcinogen. For the inhibition of normal function in gap junction, part of a connexin gene is made to be deficient and a plasmid vector engineered to carry a gene deficient in connexin function is introduced into a rat to make a transgenic rat. By using the rat of the present invention, it becomes possible to detect a carcinogen highly sensitively and more easily in a short time, and the rat of the present invention made to develop a cancer can be effectively used for the screening of anticancer substances.

    摘要翻译： 为了能够在短时间内高度敏感地且更容易地检测致癌物，本发明提供了对致癌物具有高敏感性的大鼠和使用大鼠检测致癌物质的方法，以及用于筛选抗癌剂的方法 使用大鼠制造癌症的物质。 已经发现，在间隙连接处正常功能被抑制的大鼠对致癌物质具有高敏感性。 为了抑制间隙连接中的正常功能，使连接蛋白基因的一部分缺陷，并将工程改造的携带缺失连接蛋白功能的基因的质粒载体导入大鼠中以制备转基因大鼠。 通过使用本发明的大鼠，可以在短时间内高度敏感地且更容易地检测致癌物，并且可以有效地利用制造癌症的本发明的大鼠来筛选抗癌物质。

    Relative velocity sensing device
    4.
    发明授权
    Relative velocity sensing device 失效
    相对速度感测装置

    公开(公告)号：US5365060A

    公开(公告)日：1994-11-15

    申请号：US38783

    申请日：1993-03-29

    申请人： Tomoyuki Shirai

    发明人： Tomoyuki Shirai

    IPC分类号： G11B7/085 ,  F02B75/02 ,  G01P3/36 ,  G01P3/42 ,  G11B21/08 ,  G01D5/34

    CPC分类号： G01P3/36 ,  F02B2075/025

    摘要： A relative velocity sensing device for sensing an optical beam spot, for example, by using a tracking error difference signal that fluctuates as a sine-wave in accordance with a movement of the beam spot. The tracking error difference signal is converted into a first sawtooth wave signal, and a second sawtooth wave signal, having a phase which is offset from the first sawtooth wave signal by one half of the period thereof. A first differential signal is obtained in accordance with the first sawtooth wave signal, and a second differential signal is obtained in accordance with the second sawtooth wave signal. The level of a tracking error sum signal is shifted to obtain a level-shifted signal, so that a polarity signal is obtained. The first differential signal is selected when the polarity signal is positive, and the second differential signal is selected when the polarity signal is negative and, thus, a velocity signal showing the velocity of the beam spot with a high accuracy may be obtained.

    摘要翻译： 一种用于感测光束点的相对速度感测装置，例如通过使用根据束斑的移动而波动为正弦波的跟踪误差差信号。 跟踪误差差信号被转换成第一锯齿波信号和第二锯齿波信号，该信号具有从第一锯齿波信号偏移其周期的一半的相位。 根据第一锯齿波信号获得第一差分信号，并且根据第二锯齿波信号获得第二差分信号。 将跟踪误差和信号的电平移位以获得电平移位信号，从而获得极性信号。 当极性信号为正时选择第一差分信号，并且当极性信号为负时选择第二差分信号，因此可以获得表示高精度的光点速度的速度信号。

    Color sign inserting circuit for video signal reproducing system
    5.
    发明授权
    Color sign inserting circuit for video signal reproducing system 失效
    用于视频信号再现系统的色标插入电路

    公开(公告)号：US4561013A

    公开(公告)日：1985-12-24

    申请号：US460079

    申请日：1983-01-20

    申请人： Tsutomu Fukui ,  Tomoyuki Shirai

    发明人： Tsutomu Fukui ,  Tomoyuki Shirai

    IPC分类号： H04N9/74 ,  H04N9/79 ,  H04N9/02

    CPC分类号： H04N9/74

    摘要： A color sign inserting circuit for a video signal reproducing system is disclosed, which comprises a the color burst detecting circuit for extracting color burst from a video signal detected from a recording system, a flywheel oscillator locked to the average values of the frequency and phase of a color burst signal extracted from the color burst detecting circuit for detecting time axis variation components, a phase shifter for controlling the phase of the clock output of the flywheel oscillator, and a sign inserting circuit for superimposing the output of the phase shifter and a sign signal on the video signal. Display of an inserted sign in color in the reproduction of video thus can be realized by merely adding an inexpensive color signal shifter to the conventional functions necessary for the video signal processing.

    摘要翻译： 公开了一种用于视频信号再现系统的彩色符号插入电路，它包括一个用于从从记录系统检测的视频信号中提取彩色脉冲串的色同步脉冲串检测电路，锁定到频率和相位的平均值的飞轮振荡器 从用于检测时间轴变化分量的色同步检测电路提取的色同步信号，用于控制飞轮振荡器的时钟输出的相位的移相器和用于叠加移相器的输出和符号的符号插入电路 信号上的视频信号。 因此，通过仅将视频信号处理所需的常规功能仅添加便宜的彩色信号移位器，可以实现在视频再现中的插入符号的显示。

    Model rat with the onset of prostatic cancer
    6.
    发明授权
    Model rat with the onset of prostatic cancer 有权
    模型大鼠与前列腺癌的发病

    公开(公告)号：US07105717B1

    公开(公告)日：2006-09-12

    申请号：US10204504

    申请日：2000-06-13

    申请人： Tomoyuki Shirai ,  Makoto Asamoto ,  Satoru Takahashi

    发明人： Tomoyuki Shirai ,  Makoto Asamoto ,  Satoru Takahashi

    IPC分类号： A01K67/00

    CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/005 ,  C12N2710/22022

    摘要： To provide a rat model with the onset of prostate cancer in which the prostate cancer including an invasive cancer can be developed and can be bred for generations stably. A rat model with the onset of prostate cancer which can develop prostate cancer including invasive cancer and can be bred for generations stably is established by: ligating an SV40 large T antigen gene onto the downstream of rat probasin gene promoter; the resulting PBSVT transgene is introduced into a fertilized egg of a Sprague-Dawley rat; after the introduction, the fertilized egg is transplanted into a recipient rat; a transgenic rat obtained from the recipient rat is then mated with a wild-type Sprague-Dawley rat; the transgenic offspring rats thus obtained are similarly can be bred for generations thereafter; and transgenic rats developing prostate cancer are selected through histopathological observation of the prostate.

    摘要翻译： 提供具有前列腺癌发病的大鼠模型，其中可以开发包括侵袭性癌症的前列腺癌并且可以稳定繁殖。 通过将SV40大T抗原基因连接到大鼠probasin基因启动子的下游，建立可以发展前列腺癌包括侵袭性癌症并可以稳定繁殖的前列腺癌的大鼠模型， 将得到的PBSVT转基因导入Sprague-Dawley大鼠的受精卵中; 引入后，将受精卵移植到受体大鼠中; 然后将从受体大鼠获得的转基因大鼠与野生型Sprague-Dawley大鼠配对; 这样获得的转基因后代大鼠同样可以繁殖后代; 并通过组织病理学观察前列腺来选择发展前列腺癌的转基因大鼠。

    Optical head locating mechanism for magnetically locating an optical head
    8.
    发明授权
    Optical head locating mechanism for magnetically locating an optical head 失效
    用于磁头定位光头的光头定位机构

    公开(公告)号：US5191570A

    公开(公告)日：1993-03-02

    申请号：US610112

    申请日：1990-11-07

    申请人： Tomoyuki Shirai

    发明人： Tomoyuki Shirai

    IPC分类号： G11B7/085

    CPC分类号： G11B7/08582

    摘要： An optical head locating mechanism for locating an optical head adapted to be positioned in an optical device at a desired point. The optical head locating mechanism comprises a first location device for floating the optical head and locating it at a desired position along a focusing direction, and a second in a direction orthogonal to a tracking direction. Thus, it becomes possible to smoothly and quickly move the optical head, and further it becomes possible to accurately locate the optical head.

    摘要翻译： 一种光学头定位机构，用于定位适于定位在光学装置中的所需点处的光学头。 光头定位机构包括用于浮动光学头并将其定位在沿着聚焦方向的期望位置的第一定位装置，以及沿与跟踪方向正交的方向上的第二定位装置。 因此，可以平滑且快速地移动光学头，并且还可以精确地定位光学头。