公开(公告)号：US20160266040A2

公开(公告)日：2016-09-15

申请号：US14538422

申请日：2014-11-11

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/64 ,  G01N1/28

CPC classification number: G01N21/64 ,  B01L3/021 ,  B01L3/0241 ,  G01N1/28 ,  G01N21/01 ,  G01N21/17 ,  G01N21/33 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  G01N2035/1062 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.

公开(公告)号：US20190331638A1

公开(公告)日：2019-10-31

申请号：US15962925

申请日：2018-04-25

Applicant: Tecan Trading AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tin Ngo ,  Tiffany Ding (Lay) ,  Torleif Ove Bjornson

IPC: G01N27/447 ,  B01L3/00

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.

公开(公告)号：US20150060700A1

公开(公告)日：2015-03-05

申请号：US14538422

申请日：2014-11-11

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/64 ,  G01N1/28

CPC classification number: G01N21/64 ,  B01L3/021 ,  B01L3/0241 ,  G01N1/28 ,  G01N21/01 ,  G01N21/17 ,  G01N21/33 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  G01N2035/1062 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.

Abstract translation: 用于分析由液体处理系统提供的液滴中包含的样品的光学测量装置和方法具有液体处理尖端。 光源照射液滴; 检测器测量样品光; 并且具有第一光学元件的光学系统透射照射光，并且处理器处理测量信号。 液滴在液体处理尖端的液体处理孔处悬挂在液滴被由光源和第一光学元件限定的第一光轴穿透的位置处。 只有液体处理尖端和液体处理尖端内的液体样品物理地接触液滴。 实现液滴相对于第一光学元件的尺寸和位置的相互适应。

公开(公告)号：US09488576B2

公开(公告)日：2016-11-08

申请号：US14794394

申请日：2015-07-08

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/17 ,  G01N21/03 ,  G01N21/13 ,  G01N21/64 ,  G01N21/59 ,  G01N35/00 ,  C12Q1/68 ,  G01N21/33 ,  G01N21/01 ,  B01L3/02 ,  G01N21/85 ,  G01N35/10

CPC classification number: G01N21/59 ,  B01L3/021 ,  B01L3/0241 ,  G01N21/01 ,  G01N21/17 ,  G01N21/33 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6486 ,  G01N35/1009 ,  G01N2021/0162 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  G01N2035/1062 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: Optical measuring apparatus for analysis of samples contained in liquid drops includes a liquid handling system with at least one liquid handling tip. The apparatus has a light source for irradiating the drop, a detector for measuring sample light, an optics system with first optical elements for transmitting irradiation light, and a processor for processing measurement signals. The drop is suspended at the liquid handling orifice of the tip in a position where the drop is penetrated by a first optical axis defined by the light source and the first optical elements. The drop is physically touched only by the liquid handling tip and the liquid sample inside the tip. The tip is attached to a robot arm which adjusts the position of the liquid drop with respect to at least one optical element of the optics system.

Abstract translation: 用于分析包含在液滴中的样品的光学测量装置包括具有至少一个液体处理尖端的液体处理系统。 该装置具有用于照射液滴的光源，用于测量样品光的检测器，具有用于发射照射光的第一光学元件的光学系统和用于处理测量信号的处理器。 液滴悬挂在尖端的液体处理孔处，其中液滴被由光源和第一光学元件限定的第一光轴穿透。 该液滴仅由液体处理尖端和尖端内部的液体样品物理接触。 尖端附接到机器人臂，其相对于光学系统的至少一个光学元件调节液滴的位置。

公开(公告)号：US09488579B2

公开(公告)日：2016-11-08

申请号：US14538422

申请日：2014-11-11

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/17 ,  G01N21/03 ,  G01N21/13 ,  G01N21/64 ,  G01N21/59 ,  G01N35/00 ,  C12Q1/68 ,  G01N1/28 ,  G01N21/01 ,  G01N21/33 ,  B01L3/02 ,  G01N21/85 ,  G01N35/10

CPC classification number: G01N21/64 ,  B01L3/021 ,  B01L3/0241 ,  G01N1/28 ,  G01N21/01 ,  G01N21/17 ,  G01N21/33 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  G01N2035/1062 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.

Abstract translation: 用于分析由液体处理系统提供的液滴中包含的样品的光学测量装置和方法具有液体处理尖端。 光源照射液滴; 检测器测量样品光; 并且具有第一光学元件的光学系统透射照射光，并且处理器处理测量信号。 液滴在液体处理尖端的液体处理孔处悬挂在液滴被由光源和第一光学元件限定的第一光轴穿透的位置处。 只有液体处理尖端和液体处理尖端内的液体样品物理地接触液滴。 实现液滴相对于第一光学元件的尺寸和位置的相互适应。

公开(公告)号：US08912007B2

公开(公告)日：2014-12-16

申请号：US13746722

申请日：2013-01-22

Applicant: Tecan Trading AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/17 ,  G01N21/64 ,  G01N35/00 ,  C12Q1/68 ,  B01L3/02 ,  G01N15/02 ,  G01N21/33 ,  G01N21/01 ,  G01N35/10 ,  G01N21/85 ,  G01N21/03

CPC classification number: G01N21/17 ,  B01L3/021 ,  B01L3/0241 ,  G01N15/0227 ,  G01N21/01 ,  G01N21/03 ,  G01N21/33 ,  G01N21/49 ,  G01N21/645 ,  G01N2015/0038 ,  G01N2015/0693 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.

Abstract translation: 用于分析由液体处理系统提供的液滴中包含的样品的光学测量装置和方法具有液体处理尖端。 光源照射液滴; 检测器测量样品光; 并且具有第一光学元件的光学系统透射照射光，并且处理器处理测量信号。 液滴在液体处理尖端的液体处理孔处悬挂在液滴被由光源和第一光学元件限定的第一光轴穿透的位置处。 只有液体处理尖端和液体处理尖端内的液体样品物理地接触液滴。 实现液滴相对于第一光学元件的尺寸和位置的相互适应。

公开(公告)号：US20150308944A1

公开(公告)日：2015-10-29

申请号：US14794394

申请日：2015-07-08

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/13 ,  G01N21/64 ,  G01N21/59 ,  G01N21/03

CPC classification number: G01N21/59 ,  B01L3/021 ,  B01L3/0241 ,  G01N21/01 ,  G01N21/17 ,  G01N21/33 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6486 ,  G01N35/1009 ,  G01N2021/0162 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  G01N2035/1062 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: Optical measuring apparatus configured for analysis of samples contained in liquid drops provided by a liquid handling system that comprises at least one liquid handling tip. The apparatus comprises a light source for irradiating the drop; a detector for measuring sample light; an optics system with first optical elements for transmitting irradiation light, and a processor for accepting and processing measurement signals. The drop is suspended at the liquid handling orifice of the tip in a position where the drop is penetrated by a first optical axis defined by the light source and the first optical elements. The drop is physically touched only by the tip and the liquid sample inside the tip. A robot arm to which the tip is attached is configured as a mechanism for adapting the position of the liquid drop with respect to at least one optical element of the optics system.

Abstract translation: 光学测量装置，其被配置用于分析由液体处理系统提供的液滴中包含的样品，所述液体处理系统包括至少一个液体处理尖端。 该装置包括用于照射该液滴的光源; 用于测量样品光的检测器; 具有用于发射照射光的第一光学元件的光学系统和用于接收和处理测量信号的处理器。 液滴悬挂在尖端的液体处理孔处，其中液滴被由光源和第一光学元件限定的第一光轴穿透。 滴液仅由尖端和尖端内的液体样品物理接触。 配置有尖端的机器人臂被配置为用于相对于光学系统的至少一个光学元件适配液滴的位置的机构。

公开(公告)号：US20140206093A1

公开(公告)日：2014-07-24

申请号：US13746722

申请日：2013-01-22

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/17

CPC classification number: G01N21/17 ,  B01L3/021 ,  B01L3/0241 ,  G01N15/0227 ,  G01N21/01 ,  G01N21/03 ,  G01N21/33 ,  G01N21/49 ,  G01N21/645 ,  G01N2015/0038 ,  G01N2015/0693 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.

Abstract translation: 用于分析由液体处理系统提供的液滴中包含的样品的光学测量装置和方法具有液体处理尖端。 光源照射液滴; 检测器测量样品光; 并且具有第一光学元件的光学系统透射照射光，并且处理器处理测量信号。 液滴在液体处理尖端的液体处理孔处悬挂在液滴被由光源和第一光学元件限定的第一光轴穿透的位置处。 只有液体处理尖端和液体处理尖端内的液体样品物理地接触液滴。 实现液滴相对于第一光学元件的尺寸和位置的相互适应。