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公开(公告)号：US5378698A
公开(公告)日：1995-01-03
申请号：US960851
申请日：1992-10-14
IPC分类号： A61K31/55 , A61K31/554 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07D281/10 , C07D417/12 , C07D417/06
CPC分类号： C07D417/12 , C07D281/10
摘要： A compound of the formula: ##STR1## wherein X is .dbd.N--A--R.sup.1 or .dbd.C(R.sup.1)R.sup.2 ; A is a single bond, polymethylene or --CO--; R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, unsubstituted or substituted phenyl, optionally substituted benzhydryl, or optionally substituted 5 to 6 membered heterocyclic group; Y is hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, optionally substituted phenoxy, optionally substituted benzyloxy, or optionally substituted benzyl; Z is hydrogen or acyl; n is an integer of from 2 to 6, and pharmaceutically acceptable salt thereof. A pharmaceutical composition containing the compound, which is useful for treating hypertension and cardiac diseases, is also provided.
摘要翻译： 下式的化合物：其中X为= N-A-R 1或= C（R 1）R 2; A是单键，聚亚甲基或-CO-; R 1和R 2各自为氢，C 1 -C 6烷基，C 3 -C 7环烷基，未取代或取代的苯基，任选取代的二苯甲基或任选取代的5至6元杂环基; Y是氢，卤素，C 1 -C 6烷基，C 3 -C 7环烷基，C 1 -C 6烷氧基，任选取代的苯氧基，任选取代的苄氧基或任选取代的苄基; Z是氢或酰基; n为2〜6的整数，及其药学上可接受的盐。 还提供含有该化合物的药物组合物，其可用于治疗高血压和心脏病。
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公开(公告)号：US5462936A
公开(公告)日：1995-10-31
申请号：US292226
申请日：1994-08-22
IPC分类号： A61K31/55 , A61K31/554 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07D281/10 , C07D417/12 , C07D417/06
CPC分类号： C07D417/12 , C07D281/10
摘要： A compound of the formula: ##STR1## wherein X is .dbd.N--A--R.sup.1 or .dbd.C(R.sup.1)R.sup.2 ; A is a single bond, polymethylerie or --CO--; R.sup.1 and R.sup.2 are each hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, unsubstituted or substituted phenyl, optionally substituted benzhydryl, or optionally substituted 5 to 6 membered heterocyclic group; Y is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-6 alkoxy, optionally substituted phenoxy, optionally substituted benzyloxy, or optionally substituted benzyl; Z is hydrogen or acyl; n is an integer of from 2 to 6, and pharmaceutically acceptable salt thereof. A pharmaceutical composition containing the compound, which is useful for treating hypertension and cardiac diseases, is also provided.
摘要翻译： 下式的化合物：其中X为= N-A-R 1或= C（R 1）R 2; A是单键，聚甲基或-CO-; R 1和R 2各自为氢，C 1-6烷基，C 3-7环烷基，未取代或取代的苯基，任选取代的二苯甲基或任选取代的5至6元杂环基; Y是氢，卤素，C 1-6烷基，C 3-6环烷基，C 1-6烷氧基，任选取代的苯氧基，任意取代的苄氧基或任选取代的苄基; Z是氢或酰基; n为2〜6的整数，及其药学上可接受的盐。 还提供含有该化合物的药物组合物，其可用于治疗高血压和心脏病。
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公开(公告)号：US5473066A
公开(公告)日：1995-12-05
申请号：US182828
申请日：1994-01-19
申请人： Teruo Yamamori , Hiroshi Harada , Eiichi Oosugi , Katsunori Sakai
发明人： Teruo Yamamori , Hiroshi Harada , Eiichi Oosugi , Katsunori Sakai
IPC分类号： B01J23/745 , B01J23/74 , C07B53/00 , C07B61/00 , C07C319/14 , C07C323/56 , C07D281/10 , C07D295/13 , C07B45/00 , C07D295/14
CPC分类号： C07D295/13 , C07C319/14 , C07C323/56 , C07D281/10
摘要： Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): ##STR1## is provided, said process comprising carrying out a stereoselective addition reaction of an o-(aminoalkylamino) thiophenyl derivative with a trans-substituted glycidic ester at an elevated temperature in a nonpolar solvent in the presence of a divalent or trivalent iron ion to prepare a threo-form intermediate, hydrolyzing the ester group of said intermediate, acetylating the hydroxyl group of said hydrolyzed compound, and subjecting said acetylated compound to a ring closure reaction to obtain the objective compound (VI).
摘要翻译： （VI）表示的5-（氨基烷基氨基）-1,5-苯并硫氮杂衍生物的顺式形式的立体选择性方法：所述方法包括进行邻位反应的立体选择性加成反应， （氨基烷基氨基）噻吩基衍生物与反式取代的缩水甘油酯在升高的温度下在非极性溶剂中在二价或三价铁离子存在下反应以制备苏式中间体，水解所述中间体的酯基，乙酰化羟基 的所述水解化合物，并使所述乙酰化合物进行闭环反应以获得目标化合物（VI）。
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公开(公告)号：US07429593B2
公开(公告)日：2008-09-30
申请号：US10489333
申请日：2001-09-14
IPC分类号： A01N43/54 , A01N43/40 , C07D239/42 , C07D401/04 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D211/72 , C07D211/84 , C07D213/00 , A61K31/44
CPC分类号： C07D213/75 , A61K31/165 , A61K31/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
摘要翻译： 提供具有增强载脂蛋白A表达活性的化合物，其用作药物。 式（I）的化合物：其中环A和Ar 1独立地是单环或双环芳族碳环基或芳族杂环基，其各自可以被任选取代;等等; R为氢等; Z是氧等; Y 1和Y 2是氢，低级烷基等; n为0〜2的整数， 虚线是存在或不存在债券; 并且波浪线表示相对于双键的顺式或反式几何异构体; 被披露。
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公开(公告)号：US20080221112A1
公开(公告)日：2008-09-11
申请号：US12081662
申请日：2008-04-18
IPC分类号： A61K31/498 , A61K31/4402 , A61P9/10
CPC分类号： C07D213/75 , A61K31/165 , A61K31/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
摘要翻译： 提供具有增强载脂蛋白A表达活性的化合物，其用作药物。 式（I）的化合物：其中环A和Ar 1独立地是单环或双环芳族碳环基或芳族杂环基，其各自可以被任选取代;等等; R为氢等; Z是氧等; Y 1和Y 2是氢，低级烷基等; n为0〜2的整数， 虚线是存在或不存在债券; 并且波浪线表示相对于双键的顺式或反式几何异构体; 被披露。
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公开(公告)号：US08106051B2
公开(公告)日：2012-01-31
申请号：US12081662
申请日：2008-04-18
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D213/75 , A61K31/165 , A61K31/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
摘要翻译： 提供具有增强载脂蛋白A表达活性的化合物，其用作药物。 式（I）的化合物：其中环A和Ar 1独立地是单环或双环芳族碳环基或芳族杂环基，其各自可以被任选取代;等等; R为氢等; Z是氧等; Y1和Y2是氢，低级烷基等; n为0〜2的整数， 虚线是存在或不存在债券; 并且波浪线表示相对于双键的顺式或反式几何异构体; 被披露。
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公开(公告)号：US08439470B2
公开(公告)日：2013-05-14
申请号：US13239999
申请日：2011-09-22
申请人： Katsunori Sakai
发明人： Katsunori Sakai
IPC分类号： B41J29/38
CPC分类号： B41J2/2142 , B41J11/0095
摘要： A liquid ejecting device to eject droplets of liquid onto a recording medium is provided. The image ejecting device includes a recording medium conveyer, a liquid ejecting head, a detector unit, an image data storage, a controller, and a cancellation signal output unit to output cancellation signals in an error condition. The controller includes a creating unit to create first dot pattern data and sum segments extracted from the first dot pattern data to create second dot pattern data, a transmission unit, and a cancellation controller unit to stop the creating unit, create second dot pattern data by adding a dot pattern to the segments having been extracted from the first dot pattern data, and transmit the created second dot pattern data to the transmission unit. The controller controls the liquid ejecting head to eject the droplets from the nozzles according to the second dot pattern data.
摘要翻译： 提供了一种将液体液滴喷射到记录介质上的液体喷射装置。 图像喷射装置包括记录介质输送器，液体喷射头，检测器单元，图像数据存储器，控制器和抵消信号输出单元，以在错误状态下输出抵消信号。 该控制器包括：创建单元，用于创建从第一点图案数据提取的第一点阵图形数据和和段，以创建第二点阵图形数据，发送单元和取消控制器单元，以停止创建单元，通过以下步骤创建第二点阵图数据： 向从第一点图案数据提取的段添加点图案，并将所创建的第二点图案数据发送到发送单元。 控制器控制液体喷射头，以根据第二点图案数据从喷嘴喷射液滴。
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公开(公告)号：US20070148528A1
公开(公告)日：2007-06-28
申请号：US11644875
申请日：2006-12-26
申请人： Katsunori Sakai
发明人： Katsunori Sakai
CPC分类号： H01M8/04231 , H01M8/0612 , H01M8/0662 , Y02P70/56
摘要： A fuel cell generating system can reduce or prevent the degradation and increase the durability of a fuel cell main body without increasing the volume of the fuel cell generating system includes a fuel cell main body comprises an electrolyte membrane, an anode electrode and a cathode electrode disposed on separate sides of the electrolyte membrane, a first separator having gas flow channels that supply a fuel gas containing hydrogen to the anode electrode and a second separator having oxidant gas flow channels to supply an oxidant gas containing oxygen to the cathode electrode. A gas supply system that supplies a non-reactive gas to the anode gas flow channel besides the oxidant gas and the fuel gas, wherein, during a starting operation, a predetermined amount of the non-reactive gas is supplied to the anode gas flow channel, and the fuel gas is supplied after the supply the non-reactive gas.
摘要翻译： 燃料电池产生系统可以在不增加燃料电池产生系统的体积的情况下降低或防止燃料电池主体的劣化和增加耐用性。包括燃料电池主体，其包括电解质膜，阳极电极和阴极电极 在所述电解质膜的分离侧，具有向所述阳极电极供给含有氢的燃料气体的气体流路的第一分离器和具有氧化剂气体流路的第二分离器，以向所述阴极供给含氧的氧化剂气体。 一种气体供给系统，其除了氧化剂气体和燃料气体之外还向阳极气体流动通道提供非反应性气体，其中在启动操作期间，将预定量的非反应性气体供应到阳极气体流动通道 并且在供给非反应性气体之后供给燃料气体。
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公开(公告)号：US5085949A
公开(公告)日：1992-02-04
申请号：US650761
申请日：1991-02-05
IPC分类号： H01M8/04
CPC分类号： H01M8/04552 , H01M8/04029 , H01M8/04365 , H01M8/04671 , H01M8/04768
摘要： A fuel cell generation system comprises a cell stack consisting of a plurality of cells, said cell having a fuel electrode, an oxidizer electrode, and an electrolyte layer located between said both electrodes, a fuel cell main body having a plurality of cooling plates for absorbing heat generated in said cell, said plate being located between said cells, and a cooling unit for supplying a coolant through said cooling plate. The system further provides a reference voltage source for supplying a reference voltage and a determining unit for comparing an output voltage of at least one cell located at the upper portion of the cell main body with the reference voltage and determining if an abnormal state occurs in the cooling unit based on the comparing result. The reference voltage is picked up out of a part of the cell stack.
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10.发明授权Sealing member for fuel cell, fuel cell, and method of manufacturing the fuel cell 有权燃料电池用密封材料，燃料电池及燃料电池的制造方法公开(公告)号：US07897288B2
公开(公告)日：2011-03-01
申请号：US11607886
申请日：2006-12-04
申请人： Aihara Yuichi , Katsunori Sakai
发明人： Aihara Yuichi , Katsunori Sakai
CPC分类号： H01M8/0276 , H01M8/0258 , H01M8/0273 , H01M8/0284 , Y02P70/56
摘要： A sealing member for a fuel cell includes a pair of belts that include non-gas transmitting layers formed of aromatic polyimide or aluminum and thermoplastic resin layers. The belts are disposed such that the thermoplastic resin layers of the belts face each other, and the thermoplastic resin layers in outer edge portions of the belts are thermally bonded to each other. In a fuel cell, an inner portion of the belts engage the electrolyte membrane.
摘要翻译： 燃料电池用密封材料包括一对带，其包括由芳族聚酰亚胺或铝和热塑性树脂层形成的非气体透过层。 皮带被布置成使得带的热塑性树脂层彼此面对，并且带的外边缘部分中的热塑性树脂层彼此热粘合。 在燃料电池中，带的内部接合电解质膜。
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