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公开(公告)号：US08106051B2
公开(公告)日：2012-01-31
申请号：US12081662
申请日：2008-04-18
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D213/75 , A61K31/165 , A61K31/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
摘要翻译： 提供具有增强载脂蛋白A表达活性的化合物，其用作药物。 式（I）的化合物：其中环A和Ar 1独立地是单环或双环芳族碳环基或芳族杂环基，其各自可以被任选取代;等等; R为氢等; Z是氧等; Y1和Y2是氢，低级烷基等; n为0〜2的整数， 虚线是存在或不存在债券; 并且波浪线表示相对于双键的顺式或反式几何异构体; 被披露。
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公开(公告)号：US07429593B2
公开(公告)日：2008-09-30
申请号：US10489333
申请日：2001-09-14
IPC分类号： A01N43/54 , A01N43/40 , C07D239/42 , C07D401/04 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D211/72 , C07D211/84 , C07D213/00 , A61K31/44
CPC分类号： C07D213/75 , A61K31/165 , A61K31/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
摘要翻译： 提供具有增强载脂蛋白A表达活性的化合物，其用作药物。 式（I）的化合物：其中环A和Ar 1独立地是单环或双环芳族碳环基或芳族杂环基，其各自可以被任选取代;等等; R为氢等; Z是氧等; Y 1和Y 2是氢，低级烷基等; n为0〜2的整数， 虚线是存在或不存在债券; 并且波浪线表示相对于双键的顺式或反式几何异构体; 被披露。
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公开(公告)号：US20080221112A1
公开(公告)日：2008-09-11
申请号：US12081662
申请日：2008-04-18
IPC分类号： A61K31/498 , A61K31/4402 , A61P9/10
CPC分类号： C07D213/75 , A61K31/165 , A61K31/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
摘要翻译： 提供具有增强载脂蛋白A表达活性的化合物，其用作药物。 式（I）的化合物：其中环A和Ar 1独立地是单环或双环芳族碳环基或芳族杂环基，其各自可以被任选取代;等等; R为氢等; Z是氧等; Y 1和Y 2是氢，低级烷基等; n为0〜2的整数， 虚线是存在或不存在债券; 并且波浪线表示相对于双键的顺式或反式几何异构体; 被披露。
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4.发明授权Method of enhancing the expression of apolipoprotein AI using olefin derivatives 有权使用烯烃衍生物增强载脂蛋白AI表达的方法公开(公告)号：US08124625B2
公开(公告)日：2012-02-28
申请号：US10489365
申请日：2001-09-14
IPC分类号： A61K31/445 , A61K31/44
CPC分类号： C07D213/06 , A61K31/215 , A61K31/40 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/55 , C07D213/57 , C07D215/04 , C07D215/14 , C07D235/18 , C07D241/42 , C07D263/57 , C07D277/66 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04
摘要： Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2—, —CY2═CZ2—, —CY2Y3—CHZ2—, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.
摘要翻译： 提供了具有增强载脂蛋白A表达的活性的化合物。 式（I）化合物：其中Ar 1和Ar 2独立地为可任意取代的苯基，萘基或单环或双环芳族杂环基; -X-是-N = CZ2-，-CY2 = CZ2-，-CY2Y3-CHZ2-，-S-，-O-等; Y 1，Y 2，Y 3，Z 1和Z 2独立地为氢，卤素，低级烷基，苯基等; Z1和Z2可以独立地是可以与Ar2和Ar1结合形成稠环的连接基团; m为0或1，n为0至2; 其前药，其药学上可接受的盐或溶剂合物; 被披露。
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公开(公告)号：US20090036457A1
公开(公告)日：2009-02-05
申请号：US12230993
申请日：2008-09-09
IPC分类号： A61K31/498 , A61K31/47 , A61K31/44 , A61K31/4436 , A61K31/4184 , A61K31/428 , A61K31/423 , A61P9/10
CPC分类号： C07D213/06 , A61K31/215 , A61K31/40 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/55 , C07D213/57 , C07D215/04 , C07D215/14 , C07D235/18 , C07D241/42 , C07D263/57 , C07D277/66 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04
摘要： Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2-, —CY2═CZ2-, —CY2Y3—CHZ2-, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.
摘要翻译： 提供了具有增强载脂蛋白A表达的活性的化合物。 式（I）化合物：其中Ar 1和Ar 2独立地为可任意取代的苯基，萘基或单环或双环芳族杂环基; -X-是-N-CZ2-，-CY2-CZ2-，-CY2Y3-CHZ2-，-S-，-O-等; Y 1，Y 2，Y 3，Z 1和Z 2独立地为氢，卤素，低级烷基，苯基等; Z1和Z2可以独立地是可以与Ar2和Ar1结合形成稠环的连接基团; m为0或1，n为0至2; 其前药，其药学上可接受的盐或溶剂合物; 被披露。
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公开(公告)号：US08053445B2
公开(公告)日：2011-11-08
申请号：US12230993
申请日：2008-09-09
申请人： Teruo Yamamori , Kiyoshi Nagata , Kunio Hayashi
发明人： Teruo Yamamori , Kiyoshi Nagata , Kunio Hayashi
IPC分类号： A61K31/47
CPC分类号： C07D213/06 , A61K31/215 , A61K31/40 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/55 , C07D213/57 , C07D215/04 , C07D215/14 , C07D235/18 , C07D241/42 , C07D263/57 , C07D277/66 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04
摘要： Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2—, —CY2═CZ2—, —CY2Y3—CHZ2—, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.
摘要翻译： 提供了具有增强载脂蛋白A表达的活性的化合物。 式（I）化合物：其中Ar 1和Ar 2独立地为可任意取代的苯基，萘基或单环或双环芳族杂环基; -X-是-N = CZ2-，-CY2 = CZ2-，-CY2Y3-CHZ2-，-S-，-O-等; Y 1，Y 2，Y 3，Z 1和Z 2独立地为氢，卤素，低级烷基，苯基等; Z1和Z2可以独立地是可以与Ar2和Ar1结合形成稠环的连接基团; m为0或1，n为0至2; 其前药，其药学上可接受的盐或溶剂合物; 被披露。
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公开(公告)号：US07893638B2
公开(公告)日：2011-02-22
申请号：US11979250
申请日：2007-10-31
申请人： Sadahiro Akama , Shuji Agatsuma , Nobumasa Ueda , Masahiro Kuroda , Kiyoshi Nagata , Masaya Ootake
发明人： Sadahiro Akama , Shuji Agatsuma , Nobumasa Ueda , Masahiro Kuroda , Kiyoshi Nagata , Masaya Ootake
IPC分类号： H02P23/12
摘要： A motor driving apparatus has a loss-of-synchronism monitoring circuit that monitors the rotation of a rotary machine such as a brushless DC motor to detect a sign of transition to a state of loss of synchronism. When the sign is detected, an energization control circuit temporarily stops driving of the rotary machine to bring it into a free running state, and thereafter carries out control so as to resume driving of the rotary machine. Further, the motor driving apparatus has an inverter and a drive control circuit that controls switching operation of the inverter based on rotation of the rotary machine.
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公开(公告)号：US20100116361A1
公开(公告)日：2010-05-13
申请号：US12613099
申请日：2009-11-05
IPC分类号： F16K31/20
CPC分类号： F02M37/106 , B60K15/077 , B60K2015/03105 , B60K2015/03217 , F02M37/0094 , F02M37/12 , Y10T137/7323
摘要： A fuel pump control device is for a fuel supply system for an engine. The system includes a fuel tank, a subtank, a fuel pump pumping fuel in the subtank for supply to the engine, a pressure regulator regulating fuel pressure from the fuel pump within a set pressure, and a jet pump pumping fuel in the fuel tank into the subtank through pumping action by a fuel ejection flow to the fuel tank through a return pipe of the regulator. The device includes a fuel level detecting unit for detecting fuel tank level and a control unit for controlling fuel discharge amount from the fuel pump. The control unit sets jet pump drive correction amount of fuel for driving the jet pump based on the fuel tank level. The control unit increases the fuel discharge amount from the fuel pump by the correction amount to drive the jet pump.
摘要翻译： 燃料泵控制装置用于发动机的燃料供给系统。 该系统包括一个燃料箱，一个子容器，一个燃料泵，在子容纳槽中抽出燃料以供给发动机;一个压力调节器，调节来自燃料泵的燃料压力在一个设定的压力范围内;一个喷射泵将燃料箱中的燃料泵入 子容器通过通过调节器的返回管的燃料喷射流向燃料箱的泵送作用。 该装置包括用于检测燃料箱液位的燃料液位检测单元和用于控制来自燃料泵的燃料排出量的控制单元。 控制单元基于燃料箱水平设定用于驱动喷射泵的喷射泵驱动校正量的燃料。 控制单元将来自燃料泵的燃料排出量增加到驱动喷射泵的校正量。
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公开(公告)号：US20100116253A1
公开(公告)日：2010-05-13
申请号：US12605714
申请日：2009-10-26
CPC分类号： F02M37/10 , F02D41/2464 , F02D41/3082 , F02M37/46
摘要： An integrated value of discharge quantity of a fuel pump is used as a parameter evaluating a pressure loss of a fuel filter. A target discharge quantity is obtained by correcting a fuel quantity required by an engine with a filter pressure loss correction amount corresponding to an integrated value of the discharged quantity. A target rotational speed of the fuel pump is computed based on the target discharge quantity, so that the target rotational speed is corrected in accordance with the pressure loss of the fuel filter. Alternatively, the target rotational speed may be corrected in accordance with a deterioration degree of the fuel pump.
摘要翻译： 使用燃料泵的排出量的积分值作为评价燃料过滤器的压力损失的参数。 通过利用与排出量的积分值相对应的过滤器压力损失校正量来校正发动机所需的燃料量来获得目标排出量。 基于目标排出量计算燃料泵的目标转速，从而根据燃料过滤器的压力损失校正目标转速。 或者，可以根据燃料泵的劣化程度来校正目标转速。
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公开(公告)号：US20070052310A1
公开(公告)日：2007-03-08
申请号：US11515790
申请日：2006-09-06
申请人： Hiromi Sakai , Kiyoshi Nagata , Shinji Sumiya
发明人： Hiromi Sakai , Kiyoshi Nagata , Shinji Sumiya
CPC分类号： F04D5/002 , F02M37/048 , F04D13/064 , H02K1/2733 , H02K1/28 , H02K5/12 , H02K15/03
摘要： A fluid pump includes a motor portion that has a stationary part and a rotator. The inner circumferential periphery of the stationary part and the outer circumferential periphery of the rotator define a fuel passage therebetween. The rotator is rotatable around the inner circumferential periphery of the stationary part. The motor portion drives a pump portion for pumping fuel through the fuel passage. The rotator includes a permanent magnet that is formed by injection molding a composite material containing a magnetic material and resin. The permanent magnet has one end with respect to the axial direction of the permanent magnet. The one end defines an axial end surface. The axial end surface has an injection port mark.
摘要翻译： 流体泵包括具有静止部分和旋转器的马达部分。 固定部的内周面和旋转体的外周周缘之间形成燃料通路。 旋转体可围绕静止部分的内圆周旋转。 马达部分驱动泵部分，以将燃料泵送通过燃料通道。 旋转体包括通过注射成型含有磁性材料和树脂的复合材料形成的永磁体。 永磁体相对于永磁体的轴向具有一端。 一端限定轴向端面。 轴向端面具有注射口标记。
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