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公开(公告)号：US20130253141A1
公开(公告)日：2013-09-26
申请号：US13792832
申请日：2013-03-11
发明人： Frank J. Feher , Gregory M. Whited , Gopal K. Chotani , Fernando Valle , Carol Fioresi , Karl J. Sanford , Joseph McAuliffe , Marguerite Cervin , Aaron S. Puhala , Andrei Miasnikov , Ilana S. Aldor
IPC分类号： C08F136/08 , C08F236/10 , C08F236/08
CPC分类号： C08F236/18 , C08F2/00 , C08F36/04 , C08F136/08 , C08F236/08 , C08F236/10 , C08F236/12 , C08L9/00 , C12P5/007 , Y10T436/24
摘要： It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ13C value of greater than −22‰.
摘要翻译： 已经发现，培养物中的某些细胞可将大于约0.002％的细胞培养基中可用的碳转化为异戊二烯。 这些细胞具有异源核酸，其（i）编码异戊二烯合酶多肽，和（ii）可操作地连接于启动子。 然后可以回收在这种培养基中产生的异戊二烯并聚合成合成橡胶和其它有用的聚合物材料。 本发明的合成含异戊二烯的聚合物提供可证实为从非石化基础资源得到的益处。 它们也可以分析与来自天然来源的橡胶。 本发明更具体地公开了由衍生自异戊二烯单体的重复单元组成的聚异戊二烯聚合物，其中聚异戊二烯聚合物的δ13C值大于-220 / 00。
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公开(公告)号：US08940849B2
公开(公告)日：2015-01-27
申请号：US13792832
申请日：2013-03-11
发明人： Frank J. Feher , Gregory M. Whited , Gopal K. Chotani , Fernando Valle , Carol Fioresi , Karl J. Sanford , Joseph McAuliffe , Marguerite Cervin , Aaron S. Puhala , Andrei Miasnikov , Ilana S. Aldor
IPC分类号： C08F297/04 , C08F136/08 , C08F236/08 , C07C11/18 , C08F2/00 , C08F36/04 , C08L9/00 , C12P5/00 , C08F236/10 , C12P5/02 , C08F4/48
CPC分类号： C08F236/18 , C08F2/00 , C08F36/04 , C08F136/08 , C08F236/08 , C08F236/10 , C08F236/12 , C08L9/00 , C12P5/007 , Y10T436/24
摘要： It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ13C value of greater than −22‰.
摘要翻译： 已经发现，培养物中的某些细胞可将大于约0.002％的细胞培养基中可用的碳转化为异戊二烯。 这些细胞具有异源核酸，其（i）编码异戊二烯合酶多肽，和（ii）可操作地连接于启动子。 然后可以回收在这种培养基中产生的异戊二烯并聚合成合成橡胶和其它有用的聚合物材料。 本发明的合成含异戊二烯的聚合物提供可证实为从非石化基础资源得到的益处。 它们也可以分析与来自天然来源的橡胶。 本发明更具体地公开了由衍生自异戊二烯单体的重复单元组成的聚异戊二烯聚合物，其中聚异戊二烯聚合物的δ13C值大于-22‰。
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公开(公告)号：US10774345B2
公开(公告)日：2020-09-15
申请号：US15677335
申请日：2017-08-15
发明人： Anthony R. Calabria , Marguerite A. Cervin , Gopal K. Chotani , Richard La Duca , Joseph C. McAuliffe , Michael C. Miller , Timothy A. Sabo , Karl J. Sanford , Erin. L. Spring , Gregory M. Whited
IPC分类号： C12P5/02 , C12P5/00 , C12N15/52 , C07C11/18 , C12N9/88 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80
摘要： The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
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公开(公告)号：US20150191746A1
公开(公告)日：2015-07-09
申请号：US14590882
申请日：2015-01-06
CPC分类号： C12P5/007 , C07C1/2078 , C07C1/24 , C12N9/14 , C12N9/16 , C12N9/88 , C12N9/90 , C12Y301/03 , C12Y301/07 , C12Y306/01 , C12Y503/03002
摘要： The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl deerivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene or prenyl derivatives produced there from.
摘要翻译： 本发明提供了从培养细胞产生衍生物的方法。 此外，本发明提供了通过使用化学或生物催化剂将从生物或石油化学来源获得的异戊烯基脱戊基转化为异戊二烯的方法。 本发明还提供了包含从其制备的培养细胞或异戊二烯或异戊二烯基衍生物的组合物。
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公开(公告)号：US09909144B2
公开(公告)日：2018-03-06
申请号：US14987681
申请日：2016-01-04
发明人： Marguerite A. Cervin , Gopal K. Chotani , Frank J. Feher , Richard La Duca , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Aaron S. Puhala , Karl J. Sanford , Fernando Valle , Gregory M. Whited
IPC分类号： C12N1/20 , C12N1/00 , C12N15/00 , C12P5/02 , C07H21/04 , C12P5/00 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90 , C12N15/52
CPC分类号： C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
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公开(公告)号：US09777294B2
公开(公告)日：2017-10-03
申请号：US14973485
申请日：2015-12-17
发明人： Anthony R. Calabria , Marguerite A. Cervin , Gopal K. Chotani , Richard La Duca , Joseph C. McAuliffe , Michael C. Miller , Timothy A. Sabo , Karl J. Sanford , Erin L. Spring , Gregory M. Whited
IPC分类号： C12P5/02 , C12P5/00 , C12N15/52 , C07C11/18 , C12N9/88 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80
CPC分类号： C12P5/007 , C07C11/18 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80 , C12P5/02 , C12Y402/03027 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
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公开(公告)号：US09752161B2
公开(公告)日：2017-09-05
申请号：US14148332
申请日：2014-01-06
摘要： The invention features methods producing isoprene and a co-product, such as ethanol, 1,3-propanediol, or hydrogen from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides compositions comprising isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen. Additionally, the invention provides methods of co-producing isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen by culturing cells under conditions suitable for co-production of isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen.
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8.发明申请COMPOSITIONS AND METHODS FOR PRODUCING ISOPRENE FREE OF C5 HYDROCARBONS UNDER DECOUPLING CONDITIONS AND/OR SAFE OPERATING RANGES 有权在解除条件和/或安全操作范围内生产不含C5碳氢化合物的异丙苯的组合物和方法公开(公告)号：US20140155660A1
公开(公告)日：2014-06-05
申请号：US13898320
申请日：2013-05-20
发明人： Anthony R. Calabria , Marguerite A. Cervin , Gopal K. Chotani , Richard La Duca , Joseph C. McAuliffe , Michael C. Miller , Timothy A. Sabo , Karl J. Sanford , Erin L. Spring , Gregory M. Whited
IPC分类号： C07C11/18
CPC分类号： C12P5/007 , C07C11/18 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80 , C12P5/02 , C12Y402/03027 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
摘要翻译： 本发明的特征在于从培养细胞产生异戊二烯的方法，其中固定相中的细胞。 本发明还提供包含这些培养细胞和/或增加量的异戊二烯的组合物。 本发明还提供了在气相中包括不可燃浓度的异戊二烯的体系。 此外，本发明提供了异戊二烯组合物，例如具有增加量的异戊二烯或增加的纯度的组合物。
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公开(公告)号：US20160281113A1
公开(公告)日：2016-09-29
申请号：US14987681
申请日：2016-01-04
发明人： Marguerite A. Cervin , Gopal K. Chotani , Frank J. Feher , Richard La Duca , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Aaron S. Puhala , Karl J. Sanford , Fernando Valle , Gregory M. Whited
CPC分类号： C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
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公开(公告)号：US08945893B2
公开(公告)日：2015-02-03
申请号：US13912002
申请日：2013-06-06
CPC分类号： C12P5/007 , C07C1/2078 , C07C1/24 , C12N9/14 , C12N9/16 , C12N9/88 , C12N9/90 , C12Y301/03 , C12Y301/07 , C12Y306/01 , C12Y503/03002
摘要： The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl derivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene or prenyl derivatives produced there from.
摘要翻译： 本发明提供了从培养细胞产生衍生物的方法。 此外，本发明提供了通过使用化学或生物催化剂将由生物或石油化学源获得的异戊烯基衍生物转化为异戊二烯的方法。 本发明还提供了包含从其制备的培养细胞或异戊二烯或异戊二烯基衍生物的组合物。
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