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公开(公告)号：US20180066287A1
公开(公告)日：2018-03-08
申请号：US15677335
申请日：2017-08-15
发明人： Anthony R. CALABRIA , Marguerite A. CERVIN , Gopal K. CHOTANI , Richard LA DUCA , Joseph C. MCAULIFFE , Michael C. MILLER , Timothy A. SABO , Karl J. SANFORD , Erin L. Spring , Gregory M. WHITED
IPC分类号： C12P5/00 , C12N15/80 , C12N15/75 , C12N15/74 , C12N15/70 , C12N15/52 , C07C11/18 , C12P5/02 , C12N9/88
CPC分类号： C12P5/007 , C07C11/18 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80 , C12P5/02 , C12Y402/03027 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
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2.发明申请COMPOSITIONS AND METHODS FOR PRODUCING ISOPRENE FREE OF C5 HYDROCARBONS UNDER DECOUPLING CONDITIONS AND/OR SAFE OPERATING RANGES 审中-公开在解除条件和/或安全操作范围内生产不含C5碳氢化合物的异丙苯的组合物和方法公开(公告)号：US20160281112A1
公开(公告)日：2016-09-29
申请号：US14973485
申请日：2015-12-17
发明人： Anthony R. CALABRIA , Marguerite A. CERVIN , Gopal K. CHOTANI , Richard LA DUCA , Joseph C. MCAULIFFE , Michael C. MILLER , Timothy A. SABO , Karl J. SANFORD , Erin L. WEBSTER , Gregory M. WHITED
CPC分类号： C12P5/007 , C07C11/18 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80 , C12P5/02 , C12Y402/03027 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a nonflammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
摘要翻译： 本发明的特征在于从培养细胞产生异戊二烯的方法，其中固定相中的细胞。 本发明还提供包含这些培养细胞和/或增加量的异戊二烯的组合物。 本发明还提供了在气相中包含不可燃浓度的异戊二烯的体系。 此外，本发明提供了异戊二烯组合物，例如具有增加量的异戊二烯或增加的纯度的组合物。
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公开(公告)号：US20140187839A1
公开(公告)日：2014-07-03
申请号：US14035746
申请日：2013-09-24
发明人： Frank J. FEHER , John Kaluen KAN , Joseph C. MCAULIFFE , Thomas F. MCCALL , Lawrence J. PICKERT , Christopher D. PLOETZ , Stephan RODEWALD , Timothy A. SABO , Tang H. WONG
IPC分类号： C07C7/10
CPC分类号： C07C11/18 , B01D11/0426 , B01D11/0492 , C07C7/04 , C07C7/10
摘要： Methods and apparatus for the purification of isoprene, such as the purification of a bioisoprene composition from fermentor off-gas. The apparatus includes two columns that process the fermentor off-gas, which includes isoprene and various impurities. A solvent is added to the off-gas in the first column, and the isoprene is stripped from the solvent in the second column. Also provided is a downstream further purification process. Also provided are the resulting purified isoprene compositions.
摘要翻译： 用于纯化异戊二烯的方法和装置，例如从发酵罐尾气净化生物异戊二烯组合物。 该装置包括处理发酵罐废气的两个塔，其包括异戊二烯和各种杂质。 向第一塔中的废气中加入溶剂，从第二塔中的溶剂中除去异戊二烯。 还提供了下游进一步的纯化方法。 还提供了所得纯化的异戊二烯组合物。
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公开(公告)号：US20130309743A1
公开(公告)日：2013-11-21
申请号：US13912002
申请日：2013-06-06
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C07C1/2078 , C07C1/24 , C12N9/14 , C12N9/16 , C12N9/88 , C12N9/90 , C12Y301/03 , C12Y301/07 , C12Y306/01 , C12Y503/03002
摘要： The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl derivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene or prenyl derivatives produced there from.
摘要翻译： 本发明提供了从培养细胞产生衍生物的方法。 此外，本发明提供了通过使用化学或生物催化剂将由生物或石油化学源获得的异戊烯基衍生物转化为异戊二烯的方法。 本发明还提供了包含从其制备的培养细胞或异戊二烯或异戊二烯基衍生物的组合物。
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公开(公告)号：US20180273982A1
公开(公告)日：2018-09-27
申请号：US15873761
申请日：2018-01-17
发明人： Marguerite A. CERVIN , Gopal K. CHOTANI , Frank J. FEHER , Richard LA DUCA , Joseph C. MCAULIFFE , Andrei MIASNIKOV , Caroline M. PERES , Aaron S. PUHALA , Karl J. SANFORD , Fernando VALLE , Gregory M. WHITED
CPC分类号： C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
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公开(公告)号：US20150274615A1
公开(公告)日：2015-10-01
申请号：US14682930
申请日：2015-04-09
发明人： Frank J. FEHER , John Kaluen KAN , Joseph C. MCAULIFFE , Thomas F. MCCALL , Lawrence J. PICKERT , Christopher D. PLOETZ , Stephan RODEWALD , Timothy A. SABO , Tang H. WONG
CPC分类号： C07C11/18 , B01D11/0426 , B01D11/0492 , C07C7/04 , C07C7/10
摘要： Methods and apparatus for the purification of isoprene, such as the purification of a bioisoprene composition from fermentor off-gas. The apparatus includes two columns that process the fermentor off-gas, which includes isoprene and various impurities. A solvent is added to the off-gas in the first column, and the isoprene is stripped from the solvent in the second column. Also provided is a downstream further purification process. Also provided are the resulting purified isoprene compositions.
摘要翻译： 用于纯化异戊二烯的方法和装置，例如从发酵罐尾气净化生物异戊二烯组合物。 该装置包括处理发酵罐废气的两个塔，其包括异戊二烯和各种杂质。 向第一塔中的废气中加入溶剂，从第二塔中的溶剂中除去异戊二烯。 还提供了下游进一步的纯化方法。 还提供了所得纯化的异戊二烯组合物。
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7.发明申请ENHANCED PRODUCTION OF ISOPRENE USING HOST CELLS HAVING DECREASED ISPA ACTIVITY 审中-公开使用具有减少的ISPA活性的宿主细胞增强异丙苯的生产公开(公告)号：US20150218590A1
公开(公告)日：2015-08-06
申请号：US14593860
申请日：2015-01-09
发明人： Joseph C. MCAULIFFE , Rachel E. Muir , Alex T. Nielsen , Caroline M. Peres , Dmitrii V. Vaviline , Derek H. Wells
CPC分类号： C12P5/007 , C12N9/1085 , C12N9/88 , C12Y205/01001 , C12Y402/03027 , Y02P20/52
摘要： This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
摘要翻译： 本发明涉及能够以高效率利用这种重组微生物生产异戊二烯和异戊二烯生产的重组微生物。 在本发明中，改变了ispA基因的功能活性，以减少重组细胞中产生异戊二烯的重组细胞的产生，或在发酵过程中容易受类异戊二烯积累影响的细胞中。 这种降低的ispA基因功能活性能够增强宿主微生物中异戊二烯的合成。
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公开(公告)号：US20150191746A1
公开(公告)日：2015-07-09
申请号：US14590882
申请日：2015-01-06
CPC分类号： C12P5/007 , C07C1/2078 , C07C1/24 , C12N9/14 , C12N9/16 , C12N9/88 , C12N9/90 , C12Y301/03 , C12Y301/07 , C12Y306/01 , C12Y503/03002
摘要： The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl deerivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene or prenyl derivatives produced there from.
摘要翻译： 本发明提供了从培养细胞产生衍生物的方法。 此外，本发明提供了通过使用化学或生物催化剂将从生物或石油化学来源获得的异戊烯基脱戊基转化为异戊二烯的方法。 本发明还提供了包含从其制备的培养细胞或异戊二烯或异戊二烯基衍生物的组合物。
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公开(公告)号：US20140162337A1
公开(公告)日：2014-06-12
申请号：US13940092
申请日：2013-07-11
发明人： Gopal K. CHOTANI , Joseph C. MCAULIFFE , Michael C. MILLER , Rachel E. MUIR , Dmitrii V. VAVILINE , Walter WEYLER
摘要： The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.
摘要翻译： 本发明提供了使用DXP途径和MVA途径的各种组分或与DXP途径和MVA途径相关的组分，铁 - 硫簇相互作用的氧化还原多肽和异戊二烯合酶从培养细胞产生异戊二烯的方法。 本发明还提供包括这些培养细胞的组合物。
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公开(公告)号：US20140127770A1
公开(公告)日：2014-05-08
申请号：US14148332
申请日：2014-01-06
IPC分类号： C12P5/00
摘要： The invention features methods producing isoprene and a co-product, such as ethanol, 1,3-propanediol, or hydrogen from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides compositions comprising isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen. Additionally, the invention provides methods of co-producing isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen by culturing cells under conditions suitable for co-production of isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen.
摘要翻译： 本发明的特征在于从培养细胞产生异戊二烯和共产物如乙醇，1,3-丙二醇或氢的方法。 本发明还提供包括这些培养细胞的组合物。 本发明提供了包含异戊二烯和乙醇，异戊二烯和1,3-丙二醇以及异戊二烯和氢的组合物。 另外，本发明提供了通过在适合共同生产异戊二烯和乙醇，异戊二烯和1,3-丙二醇的条件下培养细胞来共同生产异戊二烯和乙醇，异戊二烯和1,3-丙二醇以及异戊二烯和氢的方法，以及 异戊二烯和氢。
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