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公开(公告)号：US20160355844A1
公开(公告)日：2016-12-08
申请号：US15213830
申请日：2016-07-19
CPC分类号： C12P5/026 , C12N9/001 , C12N9/0071 , C12N9/88 , C12N15/52 , C12P5/02 , C12P7/16 , C12P7/18 , C12Y103/01035 , C12Y103/08 , C12Y114/11022 , C12Y401/01033 , C12Y402/01 , C12Y402/01127 , C12Y402/03027 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
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公开(公告)号：US09422578B2
公开(公告)日：2016-08-23
申请号：US13691623
申请日：2012-11-30
CPC分类号： C12P5/026 , C07C11/167 , C08F136/06 , C08J5/00 , C08J2347/00 , C12N9/001 , C12N9/88 , C12N15/52 , C12P5/02 , C12Y103/08 , C12Y401/01033 , C12Y402/01 , C12Y402/03027 , Y02E50/343 , Y02P20/52
摘要： This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
摘要翻译： 该文献描述了通过在丁二烯合成底物中形成两个乙烯基来生产丁二烯的生化途径。 本文描述的这些途径依赖于酶，例如甲羟戊酸二磷酸脱羧酶，异戊二烯合酶和用于最终酶促步骤的脱水酶。
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公开(公告)号：US20150191747A1
公开(公告)日：2015-07-09
申请号：US14656827
申请日：2015-03-13
发明人： Wendy Yiting Chen , FungMin Liew , Michael Koepke
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/1022 , C12N9/1025 , C12N9/1029 , C12N9/1085 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N15/52 , C12N15/74 , C12P7/42 , C12P9/00 , C12Y101/01088 , C12Y101/01267 , C12Y117/07001 , C12Y202/01007 , C12Y203/01009 , C12Y203/0301 , C12Y205/0101 , C12Y205/0109 , C12Y207/01036 , C12Y207/01148 , C12Y207/04002 , C12Y207/0706 , C12Y401/01033 , C12Y402/03027 , C12Y402/03046 , C12Y406/01012 , C12Y503/03002 , Y02E50/343
摘要： The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.
摘要翻译： 本发明提供了通过微生物发酵生产萜烯或其前体的方法。 通常，该方法包括在气态底物存在下培养重组细菌，由此细菌产生萜烯或其前体，例如甲羟戊酸，焦磷酸异戊烯酯，焦磷酸二甲基烯丙酯，异戊二烯，焦磷酸格那酯，和/或法呢烯 。 细菌可以包含一种或多种外源酶，例如甲羟戊酸，DXS或萜烯生物合成途径中的酶。
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公开(公告)号：US20130323820A1
公开(公告)日：2013-12-05
申请号：US13909012
申请日：2013-06-03
发明人： Wendy Yiting Chen , FungMin Liew , Michael Koepke
IPC分类号： C12N15/74
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/1022 , C12N9/1025 , C12N9/1029 , C12N9/1085 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N15/52 , C12N15/74 , C12P7/42 , C12P9/00 , C12Y101/01088 , C12Y101/01267 , C12Y117/07001 , C12Y202/01007 , C12Y203/01009 , C12Y203/0301 , C12Y205/0101 , C12Y205/0109 , C12Y207/01036 , C12Y207/01148 , C12Y207/04002 , C12Y207/0706 , C12Y401/01033 , C12Y402/03027 , C12Y402/03046 , C12Y406/01012 , C12Y503/03002 , Y02E50/343
摘要： Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed-stocks, such as turpentine. However, these production methods are expensive, unsustainable and often cause environmental problems including contributing to climate change. Microbial fermentation provides an alternative option for the production of terpenes. One or more terpenes and/or precursors can be produced by microbial fermentation of a substrate comprising CO. Recombinant microorganisms may be used in such methods. Carboxydotrophic, acetogenic, recombinant microorganisms can be used in such methods. The recombinant microorgnsims may contain exogenous mevalonate (MVA) pathway enzymes and/or DXS pathway enzymes, for example.
摘要翻译： 萜烯是用于不同行业的有价值的商业产品。 萜烯可以由石化源和萜烯原料如松节油生产。 然而，这些生产方法是昂贵的，不可持续的，并且常常导致包括气候变化的环境问题。 微生物发酵为萜烯的生产提供了替代选择。 一种或多种萜烯和/或前体可以通过包含CO的底物的微生物发酵产生。重组微生物可以用于这些方法。 在这些方法中可以使用羧基营养型，乙酰酵素，重组微生物。 例如，重组微型蛋白可以含有外源性甲羟戊酸（MVA）途径酶和/或DXS途径酶。
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公开(公告)号：US08288148B2
公开(公告)日：2012-10-16
申请号：US12335071
申请日：2008-12-15
申请人： Marguerite A. Cervin , Gopal K. Chotani , Frank J. Feher , Richard La Duca , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Aaron S. Puhala , Karl J. Sanford , Fernando Valle , Gregory M. Whited
发明人： Marguerite A. Cervin , Gopal K. Chotani , Frank J. Feher , Richard La Duca , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Aaron S. Puhala , Karl J. Sanford , Fernando Valle , Gregory M. Whited
CPC分类号： C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
摘要翻译： 本发明的特征在于从培养细胞产生异戊二烯的方法。 本发明还提供包括这些培养细胞的组合物。
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公开(公告)号：US5837839A
公开(公告)日：1998-11-17
申请号：US733825
申请日：1996-10-18
CPC分类号： C12Y401/01033 , C12N9/88
摘要： We have cloned and expressed the cDNA for human liver mevalonate pyrophosphate decarboxylase, an enzyme of the cholesterol synthesis pathway. This cDNA encodes a 400 amino acid protein (43 kDa) which resembles the coding sequence of an unidentified and incomplete open reading frame adjacent to the COQ2 gene of Saccharomyces cerevisiae. We also found an expression sequence tag clone made from human infant brain cDNA to be almost identical to our cDNA sequence.
摘要翻译： 我们克隆并表达了人肝磷酸焦磷酸脱羧酶（一种胆固醇合成途径的酶）的cDNA。 该cDNA编码400个氨基酸的蛋白质（43kDa），其类似于与酿酒酵母的COQ2基因相邻的未鉴定和不完整的开放阅读框的编码序列。 我们还发现由人类婴儿脑cDNA制成的表达序列标签克隆与我们的cDNA序列几乎相同。
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公开(公告)号：US20180273982A1
公开(公告)日：2018-09-27
申请号：US15873761
申请日：2018-01-17
发明人： Marguerite A. CERVIN , Gopal K. CHOTANI , Frank J. FEHER , Richard LA DUCA , Joseph C. MCAULIFFE , Andrei MIASNIKOV , Caroline M. PERES , Aaron S. PUHALA , Karl J. SANFORD , Fernando VALLE , Gregory M. WHITED
CPC分类号： C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
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公开(公告)号：US09909146B2
公开(公告)日：2018-03-06
申请号：US13002504
申请日：2009-07-06
申请人： Philippe Marliere
发明人： Philippe Marliere
CPC分类号： C12P5/026 , C07C2/28 , C12N9/88 , C12Y401/01033 , C07C11/02
摘要： The present invention relates to a method for generating alkenes biologically. It relates more particularly to a method for producing terminal alkenes by enzymatic decarboxylation of 3-hydroxyalkanoate molecules. The invention also relates to the enzymatic systems and the microbial strains used, and also to the products obtained.
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公开(公告)号：US20160281113A1
公开(公告)日：2016-09-29
申请号：US14987681
申请日：2016-01-04
发明人： Marguerite A. Cervin , Gopal K. Chotani , Frank J. Feher , Richard La Duca , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Aaron S. Puhala , Karl J. Sanford , Fernando Valle , Gregory M. Whited
CPC分类号： C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
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公开(公告)号：US09422580B2
公开(公告)日：2016-08-23
申请号：US13916156
申请日：2013-06-12
CPC分类号： C12P5/026 , C12N9/001 , C12N9/0071 , C12N9/88 , C12N15/52 , C12P5/02 , C12P7/16 , C12P7/18 , C12Y103/01035 , C12Y103/08 , C12Y114/11022 , C12Y401/01033 , C12Y402/01 , C12Y402/01127 , C12Y402/03027 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
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