-
公开(公告)号：US06266622B1
公开(公告)日：2001-07-24
申请号：US08980115
申请日：1997-11-26
申请人： Thomas S. Scanlan , John D. Baxter , Robert J. Fletterick , Richard L. Wagner , Peter J. Kushner , James J. Apriletti , Brian L. West , Andrew K. Shiau
发明人： Thomas S. Scanlan , John D. Baxter , Robert J. Fletterick , Richard L. Wagner , Peter J. Kushner , James J. Apriletti , Brian L. West , Andrew K. Shiau
IPC分类号： G06F1900
CPC分类号： C07K14/723 , A61K31/192 , A61K31/195 , A61K31/198 , A61K31/27 , C07K14/72 , C07K2299/00 , G01N33/68 , G01N33/78 , G01N2333/723 , G01N2500/04 , G06F19/16
摘要： The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as “TR”). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.
-
公开(公告)号：US06236946B1
公开(公告)日：2001-05-22
申请号：US08764870
申请日：1996-12-13
申请人： Thomas S. Scanlan , John D. Baxter , Robert J. Fletterick , Richard L. Wagner , Peter J. Kushner , James Apriletti , Brian West , Andrew K. Shiau
发明人： Thomas S. Scanlan , John D. Baxter , Robert J. Fletterick , Richard L. Wagner , Peter J. Kushner , James Apriletti , Brian West , Andrew K. Shiau
IPC分类号： G06F1900
CPC分类号： C07K14/72 , C07K2299/00
摘要： The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as “TR”). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.
摘要翻译： 本发明提供了基于核受体，特别是甲状腺受体（本文中称为“TR”）的三维结构产生核受体合成配体的新方法，特别是计算方法和组合物。 还提供了晶体，核受体合成配体和相关方法。
-
公开(公告)号：US06965850B2
公开(公告)日：2005-11-15
申请号：US09281717
申请日：1999-03-30
申请人： John D. Baxter , Beatrice Darimont , Weijun Feng , Robert J. Fletterick , Peter J. Kushner , Richard L. Wagner , Brian L. West , Keith R. Yamamoto
发明人： John D. Baxter , Beatrice Darimont , Weijun Feng , Robert J. Fletterick , Peter J. Kushner , Richard L. Wagner , Brian L. West , Keith R. Yamamoto
IPC分类号： G01N33/53 , C07K14/47 , C07K14/705 , C12N15/09 , G01N33/00 , G01N33/15 , G01N33/50 , G01N33/68 , G06F17/30 , G06F17/50 , H01L21/3065 , H01L21/314 , H01L21/336 , G06N7/00 , G06G7/58
CPC分类号： H01L21/3065 , G01N33/6875 , G01N2500/20 , H01L21/314 , H01L29/6659
摘要： The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. The invention includes a method for identifying residues comprising a coactivator binding site for a nuclear receptor of interest. Also included is a method of identifying agonists and/or antagonists that bind to a coactivator binding site of a nuclear receptor of interest. Agonists and antagonists of coactivator binding to nuclear receptors also are provided. The invention is exemplified by identification and manipulation of the coactivator binding site of the thyroid receptor (TR), and compounds that bind to this sites. The methods can be applied to other nuclear receptors including RAR, RXR, PPAR, VDR, ER, GR, PR, MR, and AR.
摘要翻译： 本发明涉及用于调节核受体共激活因子结合的方法和激动剂/拮抗剂化合物。 本发明包括用于鉴定残留物的方法，所述残基包含感兴趣的核受体的共激活子结合位点。 还包括鉴定结合感兴趣的核受体的共激活子结合位点的激动剂和/或拮抗剂的方法。 共激活剂与核受体结合的激动剂和拮抗剂也被提供。 本发明通过甲状腺受体（TR）的共激活因子结合位点的鉴定和操作以及与该位点结合的化合物来举例说明。 该方法可应用于其他核受体，包括RAR，RXR，PPAR，VDR，ER，GR，PR，MR和AR。
-
公开(公告)号：US07122579B2
公开(公告)日：2006-10-17
申请号：US10374681
申请日：2003-02-25
IPC分类号： A61K31/195
CPC分类号： A61K31/195 , A61K45/06 , Y10S514/913
摘要： The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for effect on intraocular pressure, aqueous pressure, hydraulic conductivity, hyaluronic acid secretion, and extracellular matrix assembly are provided. Methods of treating glaucoma and treating excess intraocular pressure with synthetic thyroid hormones and compositions therefore are also provided.
-
5.发明授权Method for creating specific, high affinity nuclear receptor pharmaceuticals 失效用于产生特异性，高亲合力的核受体药物的方法公开(公告)号：US07302347B2
公开(公告)日：2007-11-27
申请号：US10317034
申请日：2002-12-10
CPC分类号： C40B40/04 , G01N33/743 , G01N2333/723 , G01N2800/108 , Y10S707/99943
摘要： This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are included along with nuclear receptor agonist complexes and libraries of agonists.
摘要翻译： 本发明涉及激活核受体的激动剂。 这些激动剂包括与天然配体结合口外的核受体的区域接触的延伸。 用于制备，鉴定和设计这种激动剂的方法包括核受体激动剂复合物和激动剂文库。
-
公开(公告)号：US6054485A
公开(公告)日：2000-04-25
申请号：US915232
申请日：1997-08-20
IPC分类号： A61K9/00 , A61K9/127 , A61K31/195 , A61K31/198 , A61K31/205 , A61K31/27 , A61K38/23 , A61K45/06 , A61K47/30 , A61P27/06 , A61P43/00 , G01N33/15 , G01N33/50 , G01N33/566
CPC分类号： A61K31/195 , A61K45/06 , Y10S514/913
摘要： The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for effect on intraocular pressure, aqueous pressure, hydraulic conductivity, hyaluronic acid secretion, and extracellular matrix assembly are provided. Methods of treating glaucoma and treating excess intraocular pressure with synthetic thyroid hormones and compositions therefore are also provided.
-
公开(公告)号：US06555582B1
公开(公告)日：2003-04-29
申请号：US09371592
申请日：1999-08-10
IPC分类号： A61K31195
CPC分类号： A61K31/195 , A61K45/06 , Y10S514/913
摘要： The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for effect on intraocular pressure, aqueous pressure, hydraulic conductivity, hyaluronic acid secretion, and extracellular matrix assembly are provided. Methods of treating glaucoma and treating excess intraocular pressure with synthetic thyroid hormones and compositions therefore are also provided.
-
公开(公告)号：US5883294A
公开(公告)日：1999-03-16
申请号：US877792
申请日：1997-06-18
申请人： Thomas S. Scanlan , Grazia Chiellini , Hikari Yoshihara , James Apriletti , John D. Baxter , Ralff C. J. Ribeiro
发明人： Thomas S. Scanlan , Grazia Chiellini , Hikari Yoshihara , James Apriletti , John D. Baxter , Ralff C. J. Ribeiro
IPC分类号： A61P3/04 , A61K31/192 , A61K31/216 , A61P3/06 , A61P5/14 , A61P9/00 , A61P9/10 , A61P19/10 , A61P25/24 , C07C59/68 , C07C59/70 , C07C59/84 , C07C59/90 , C07C69/734 , C07C69/738 , C07C59/56
摘要： Selective thyroid hormone agonists are disclosed that are highly selective for the TR.beta. subtype with high binding affinity. Methods of using such agonists and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.
摘要翻译： 公开了对具有高结合亲和力的TRβ亚型具有高选择性的选择性甲状腺激素激动剂。 还公开了使用这些激动剂和含有它们的药物组合物的方法，以及它们制备的新方法。
-
公开(公告)号：US4675297A
公开(公告)日：1987-06-23
申请号：US532107
申请日：1983-09-14
IPC分类号： C07K14/575 , C12N1/20 , C07H21/04 , C12N1/00 , C12N15/00 , C12P19/34 , C12P21/00 , C12P21/02
CPC分类号： C07K14/57554 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A DNA sequence encoding bovine prolactin and optionally including condons for the preceding 10 amino acids is used to construct expression systems to obtain recombinant production of these proteins.
摘要翻译： 使用编码牛催乳素并任选地包含前10个氨基酸的宽带的DNA序列构建表达系统以获得这些蛋白质的重组产生。
-
公开(公告)号：US4322499A
公开(公告)日：1982-03-30
申请号：US972430
申请日：1978-12-22
IPC分类号： C07K14/665 , C12N1/00
CPC分类号： C07K14/665
摘要： A technique suitable for cloning a cDNA having a base sequence coding for the ACTH/LPH precursor is disclosed. The invention is exemplified by the cloning of a cDNA fragment comprising a base sequence coding for the endorphin region. The fragment, hereinafter termed the endorphin gene cDNA sequence, was obtained from cultured mouse pituitary tumor cells known to produce the ACTH/LPH precursor protein.
摘要翻译： 公开了一种适用于克隆编码ACTH / LPH前体碱基序列的cDNA的技术。 通过克隆包含编码内啡肽区域的碱基序列的cDNA片段来举例说明本发明。 该片段（以下称为内啡肽基因cDNA序列）从已知产生ACTH / LPH前体蛋白的培养的小鼠垂体肿瘤细胞获得。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.069 秒)
