公开(公告)号：US5667644A

公开(公告)日：1997-09-16

申请号：US599242

申请日：1996-02-09

申请人： Tomoyuki Mori ,  Kouichi Fujita ,  Yuuji Kajita ,  Masaki Takai

发明人： Tomoyuki Mori ,  Kouichi Fujita ,  Yuuji Kajita ,  Masaki Takai

IPC分类号： C07C45/74 ,  C07C45/82

CPC分类号： C07C45/74 ,  Y02P20/127

摘要： A method for producing a dimerized aldehyde, which comprises subjecting a feed aldehyde to a condensation reaction and a dehydration reaction in the presence of a basic catalyst, wherein the feed aldehyde is the one having one or two hydrogen atoms at the .alpha.-position, an organic feed stream containing the feed aldehyde is supplied to a reactive distillation column, and the condensation reaction and the dehydration reaction are carried out simultaneously in the reactive distillation column.

摘要翻译： 一种生产二聚醛的方法，其包括在碱性催化剂存在下使进料醛进行缩合反应和脱水反应，其中进料醛是在α-位具有一个或两个氢原子的进料醛， 将含有进料醛的有机进料流供给反应性蒸馏塔，在反应蒸馏塔中同时进行缩合反应和脱水反应。

公开(公告)号：US5936130A

公开(公告)日：1999-08-10

申请号：US926481

申请日：1997-09-10

申请人： Tomoyuki Mori ,  Masaki Takai ,  Tomohiko Inoue ,  Kazuyuki Yokoyama

发明人： Tomoyuki Mori ,  Masaki Takai ,  Tomohiko Inoue ,  Kazuyuki Yokoyama

IPC分类号： C01G55/00 ,  B01J31/24 ,  B01J31/40 ,  C07C45/50 ,  C07C47/055

CPC分类号： B01J31/1845 ,  B01J31/2404 ,  B01J31/4046 ,  B01J31/4053 ,  C07C45/50 ,  B01J2231/321 ,  B01J2531/822 ,  B01J31/0235 ,  B01J31/04 ,  B01J31/26 ,  Y02P20/584

摘要： A process for producing a rhodium complex solution, which comprises contacting an aqueous solution of a water-soluble rhodium compound and an organic solvent solution of a water-insoluble tertiary organic phosphorus compound, preferably in the presence of a C.sub.2-8 carboxylic acid, in a gas atmosphere containing carbon monoxide, followed by two phase separation, and recovering an organic solvent phase containing a rhodium-tertiary organic phosphorus compound complex. As the above aqueous solution of a rhodium compound, an aqueous solution having rhodium extracted into an aqueous phase from a waste catalyst liquid separated from a hydroformylation reaction step by oxidation treatment in the presence of a recovery accelerator such as a carboxylic acid, an amine, ammonia or an inorganic acid, is used, whereby recycling of rhodium represented by hydroformylation reaction/recovery of the catalyst/regeneration of the catalyst, is made possible, and a cumbersome step of preparing a complex catalyst from an inorganic salt or the like, or a step of preparing a soluble salt from a metal or oxide by combustion in water of the recovered catalyst, can be omitted.

摘要翻译： 一种制备铑络合物溶液的方法，其包括使水溶性铑化合物的水溶液与水不溶性叔有机磷化合物的有机溶剂溶液，优选在C2-8羧酸存在下，在 含有一氧化碳的气体气氛，然后进行两相分离，并回收含有铑 - 叔有机磷化合物络合物的有机溶剂相。 作为上述铑化合物的水溶液，通过在回收促进剂如羧酸，胺等存在下，通过氧化处理，从加氢甲酰化反应步骤中分离出的废催化剂液体将含有铑的水溶液萃取到水相中， 氨或无机酸，从而可以通过加氢甲酰化反应/催化剂的回收/催化剂的再生来代替的铑的回收成为可能，并且从无机盐等制备复合催化剂的繁琐步骤，或 可以省略通过在回收的催化剂的水中燃烧而从金属或氧化物制备可溶性盐的步骤。

公开(公告)号：US5672766A

公开(公告)日：1997-09-30

申请号：US568970

申请日：1995-12-07

申请人： Tomoyuki Mori ,  Masaki Takai ,  Tomohiko Inoue

发明人： Tomoyuki Mori ,  Masaki Takai ,  Tomohiko Inoue

IPC分类号： C07C45/50

CPC分类号： C07C45/50

摘要： A method for producing aldehydes, which comprises reacting an olefinic unsaturated compound with carbon monoxide and hydrogen for hydroformylation in the presence of a rhodium-phosphite complex catalyst to obtain a reaction product solution containing the rhodium-phosphite complex catalyst and an aldehyde product, and separating from the reaction product solution at least one component selected from the group consisting of carbon monoxide, hydrogen, an unreacted olefinic unsaturated compound, the aldehyde product, a solvent, a medium-boiling by-product and a high-boiling by-product by a separating operation, wherein at least one separating operation is carried out substantially in the absence of water, and the temperature and the residence time in the separating operation are selected to be within such ranges that value P calculated from the following formula (1) would be at most 1: P=5.0.times.10.sup.3 .times.exp�-5000/(T.sub.1 +273)!.times..theta.T.sub.1(1) where T.sub.1 is the maximum temperature (.degree.C.) in the separating operation, and .theta.T.sub.1 is the residence time (minutes) of the liquid in the separating operation.

摘要翻译： 一种生产醛的方法，其包括使烯属不饱和化合物与一氧化碳和氢气在铑 - 亚磷酸盐配合物催化剂存在下进行加氢甲酰化反应，得到含有铑 - 亚磷酸盐配合物催化剂和醛产物的反应产物溶液，并分离 从反应产物溶液中选择一种或多种选自一氧化碳，氢气，未反应的烯属不饱和化合物，醛产物，溶剂，中沸腾副产物和高沸点副产物的至少一种组分 分离操作，其中基本上在没有水的情况下进行至少一个分离操作，并且将分离操作中的温度和停留时间选择为在下式（1）计算出的值P为 最多1：P = 5.0×103×exp [-5000 /（T1 + 273）]×θT1（1）其中T1是分离中的最高温度（℃） 操作，θT1是分离操作中液体的停留时间（分钟）。

公开(公告)号：US5648554A

公开(公告)日：1997-07-15

申请号：US632356

申请日：1996-04-10

申请人： Tomoyuki Mori ,  Masaki Takai ,  Tomohiko Inoue

发明人： Tomoyuki Mori ,  Masaki Takai ,  Tomohiko Inoue

IPC分类号： C07C45/50 ,  C07C45/80

CPC分类号： C07C45/80 ,  C07C45/50

摘要： A method for producing aldehydes, which comprises reacting an olefinic unsaturated compound with carbon monoxide and hydrogen in a liquid phase in the presence of a Group 8 metal-phosphite complex catalyst, wherein a reaction product solution containing the complex catalyst and a high boiling by-product, obtained by the reaction, is intimately contacted with an extraction solution containing a polar solvent, to have either the complex catalyst or the high boiling by-product extracted selectively, followed by phase separation to separate a layer of the extraction solution from a layer of the reaction product solution.

摘要翻译： 一种生产醛的方法，其包括使烯属不饱和化合物与一氧化碳和氢在液相中在8族金属 - 亚磷酸盐配合物催化剂存在下反应，其中含有配合催化剂和高沸点副产物的反应产物溶液， 通过反应获得的产物与含有极性溶剂的提取溶液紧密接触，以选择性地提取复合催化剂或高沸点副产物，然后进行相分离以从层中分离提取溶液层 的反应产物溶液。

公开(公告)号：US20060106181A1

公开(公告)日：2006-05-18

申请号：US11300290

申请日：2005-12-15

申请人： Masaki Takai ,  Yoshiyuki Tanaka

发明人： Masaki Takai ,  Yoshiyuki Tanaka

IPC分类号： C08F20/10 ,  C07C69/52

CPC分类号： C07C41/16 ,  C07C67/10 ,  Y02P20/582 ,  C07C69/78 ,  C07C43/215 ,  C07C43/15 ,  C07C43/1785 ,  C07C43/23

摘要： A method for producing an allyl compound having a compositional formula different from that of an allyl starting material compound, which comprises reacting the allyl starting material compound with an oxygen nucleophilic agent in the presence of a catalyst containing at least one transition metal compound containing a transition metal selected from the group consisting of transition metals belonging to Group 8 to Group 10 of the Periodic Table and a multidentate phosphite compound.

公开(公告)号：US07423168B2

公开(公告)日：2008-09-09

申请号：US10649767

申请日：2003-08-28

申请人： Masaki Takai ,  Yoshiyuki Tanaka

发明人： Masaki Takai ,  Yoshiyuki Tanaka

IPC分类号： C07C69/76 ,  C07C41/06

CPC分类号： C07C41/16 ,  C07C41/06 ,  C07C67/10 ,  C07C69/78 ,  C07C43/15 ,  C07C43/215

摘要： A method for producing an allyl compound having a compositional formula different from that of an allyl starting material compound, which comprises reacting the allyl starting material compound with an oxygen nucleophilic agent having a structure different from that of the allyl starting material compound in the presence of a catalyst containing at least one transition metal compound containing a transition metal selected from the group consisting of transition metals belonging to Group 8 to Group 10 of the Periodic Table and a monodentate phosphite compound having a structure of the following formula (1): P(OR1)(OR2)(OR3)  (1) wherein R1, R2 and R3 are respectively independently an alkyl group which may have a substituent, carbon chains of R1, R2 and R3 may have at least one carbon-carbon double bond or triple bond, and at least two optional groups of R1, R2 and R3 may bond to each other to form at least one cyclic structure.

摘要翻译： 一种具有与烯丙基原料化合物不同的组成式的烯丙基化合物的制备方法，该方法包括使烯丙基原料化合物与具有与烯丙基原料化合物不同的结构的氧亲核剂在存在 含有至少一种含有选自属于周期表第8族至第10族的过渡金属的过渡金属的过渡金属化合物和具有下式（1）的结构的单齿亚磷酸酯化合物的催化剂： 在线公式描述=“在线公式”end =“lead”？> P（OR ^{2 ）（OR 2 < / SUP>）（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1，R 2，和 R 3分别独立地是可以具有取代基的烷基，R 1，R 2和R 3的碳链， / SUP>可能在l 东一个碳 - 碳双键或三键，并且R 1，R 2和R 3的至少两个任选基团可以键合到 彼此形成至少一个循环结构。}

公开(公告)号：US07173157B2

公开(公告)日：2007-02-06

申请号：US10650697

申请日：2003-08-29

申请人： Masaki Takai ,  Yoshiyuki Tanaka

发明人： Masaki Takai ,  Yoshiyuki Tanaka

IPC分类号： C07C41/06 ,  C07C69/76

CPC分类号： C08G63/52 ,  C07C41/16 ,  C07C67/10 ,  C07C209/66 ,  C07C2601/14 ,  C08G63/87 ,  C07C69/78 ,  C07C211/35 ,  C07C43/215 ,  C07C43/15

摘要： An allyl compound having a formula different from that of an allyl starting compound is prepared by a process of reacting the allyl starting compound with a nucleophilic agent in the presence of a catalyst containing at least one transition metal compound containing a transition metal selected from the group consisting of elements belonging to Group 8 to Group 10 of the Periodic Table and at least one bidentate coordinated phosphite compound selected from the group consisting of compounds having the following formulae (I) to (III): wherein A1 to A3 are respectively independently a diarylene group having a branched alkyl group at the ortho-position, R1 to R6 are respectively independently an alkyl group which may have a substituent or an aryl group which may have a substituent (including a heterocyclic compound forming an aromatic 6Π electron cloud on the upper and lower sides of the ring, hereinafter the same), and Z1 to Z3 are respectively independently an optionally substituted alkylene group, an optionally substituted arylene group, an optionally substituted alkylene-arylene group or an optionally substituted diarylene group.

摘要翻译： 通过使烯丙基起始化合物与亲核剂在含有至少一种含有过渡金属的过渡金属的催化剂存在下反应的方法来制备具有与烯丙基起始化合物不同的烯丙基化合物， 由属于元素周期表第8至10族的元素和至少一种选自具有下式（I）至（III）的化合物的二齿配位的亚磷酸酯化合物组成：其中A 1〜 分别独立地为在邻位具有支链烷基的二亚芳基，R 1至R 6分别独立地为 可以具有取代基的烷基或可具有取代基的芳基（包括在环的上侧和下侧形成芳香族6Pi电子云的杂环化合物，以下相同），Z 1 到Z 3 分别独立地为任选取代的亚烷基，任选取代的亚芳基，任选取代的亚烷基 - 亚芳基或任选取代的亚芳基。

公开(公告)号：US06610891B1

公开(公告)日：2003-08-26

申请号：US09454817

申请日：1999-12-03

申请人： Lionel O'Young ,  Masaki Takai ,  Tooru Tsukahara ,  Akio Nakanishi

发明人： Lionel O'Young ,  Masaki Takai ,  Tooru Tsukahara ,  Akio Nakanishi

IPC分类号： C07C4549

CPC分类号： C07C45/50 ,  B01J31/185 ,  B01J2231/321 ,  B01J2531/80 ,  B01J2531/822 ,  Y02P20/582 ,  C07C47/02

摘要： A method of producing aldehydes in a hydroformylation system wherein an olefinic compound is reacted with hydrogen and carbon monoxide in a hydroformylation reaction in the presence of a catalyst is provided. The hydroformylation system includes a reactor and a downstream catalyst process path. The temperature in the reactor and downstream catalyst process path is less than approximately 100° C., and preferably less than approximately 85° C., and most preferably less than approximately 80° C., such that formation of high boiler components from the reaction are substantially minimized. Further, the method of the present invention reduces degradation or decomposition of the catalyst, and in particular the ligand compound.

摘要翻译： 提供了一种在加氢甲酰化体系中生产醛的方法，其中烯烃化合物在氢化甲酰化反应中在催化剂存在下与氢气和一氧化碳反应。 加氢甲酰化体系包括反应器和下游催化剂​​工艺路径。 反应器和下游催化剂​​工艺路径中的温度小于约100℃，优选小于约85℃，最优选小于约80℃，从而形成来自反应的高沸点组分 基本上最小化。 此外，本发明的方法减少了催化剂，特别是配体化合物的降解或分解。

公开(公告)号：US20080057139A1

公开(公告)日：2008-03-06

申请号：US11892784

申请日：2007-08-27

申请人： Yuji Yoshinari ,  Masaki Takai ,  Makoto Hatori

发明人： Yuji Yoshinari ,  Masaki Takai ,  Makoto Hatori

IPC分类号： A61K33/00 ,  A61P17/00 ,  A61Q19/00

CPC分类号： A61Q19/007 ,  A61K8/19 ,  A61K9/08 ,  A61K33/00 ,  A61K47/02 ,  A61Q19/00 ,  A61K2300/00

摘要： The skin-care water, which is able to safely improve skin health conditions, such as dry skin, contains water from which polyvalent cations are removed and to which sodium ions are added, and may contain fragrant materials according to need. When the skin-care water is applied to skin, for example, by means of taking a bath, it improves moisture retention of skin, moisture content of skin, elasticity, texture density and the like without providing side effects, as is often not the case when a skin-care water containing chemical substances is used. Accordingly, the skin-care water is useful as a moisturizing agent for skin, and an improving agent for dry skin, itchy feeling, skin scale and atopic dermatitis.

摘要翻译： 能够安全地改善皮肤健康状况（例如皮肤干燥）的护肤水含有从其中除去多价阳离子并加入钠离子的水，并且可以根据需要含有芳香物质。 当皮肤护理用水例如通过洗澡时，可以改善皮肤的保湿性，皮肤含水量，弹性，质地密度等，而不会产生副作用 当使用含有化学物质的护肤水时。 因此，护肤水可用作皮肤的保湿剂，以及用于干性皮肤，瘙痒感，皮肤鳞片和特应性皮炎的改善剂。

公开(公告)号：US06291717B1

公开(公告)日：2001-09-18

申请号：US09457742

申请日：1999-12-10

申请人： Masaki Takai ,  Iwao Nakajima ,  Tooru Tsukahara ,  Yoshiyuki Tanaka ,  Hisao Urata ,  Akio Nakanishi

发明人： Masaki Takai ,  Iwao Nakajima ,  Tooru Tsukahara ,  Yoshiyuki Tanaka ,  Hisao Urata ,  Akio Nakanishi

IPC分类号： C07C4550

CPC分类号： C07F9/025 ,  B01J31/185 ,  B01J2231/321 ,  B01J2531/822 ,  C07C45/50 ,  Y02P20/584 ,  C07C47/02

摘要： A process for producing an aldehyde, which comprises a reaction step of producing an aldehyde by reacting an olefinic compound with carbon monoxide and hydrogen in the presence of a rhodium complex catalyst comprising at least rhodium and an organic phosphite in a reaction zone, a separation step of obtaining a catalyst solution containing the rhodium complex catalyst by separating the aldehyde from a reaction solution taken from the reaction zone, and a recycling step of recycling the catalyst solution into the reaction zone, wherein the aldehyde is separated from the reaction solution in such a manner as to make an aldehyde concentration from 0.5 to 99 wt % in the catalyst solution.

摘要翻译： 一种生产醛的方法，其包括在反应区中在至少包含铑和有机亚磷酸酯的铑络合物催化剂的存在下使烯属化合物与一氧化碳和氢气反应制备醛的反应步骤，分离步骤 通过从取自反应区的反应溶液中分离醛获得含有铑络合物催化剂的催化剂溶液，以及将催化剂溶液再循环到反应区中的再循环步骤，其中醛与反应溶液分离 以使催化剂溶液中醛浓度为0.5〜99重量％。