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    p53 activator peptides
    8.
    发明授权
    p53 activator peptides 有权
    p53激活肽

    公开(公告)号：US08343760B2

    公开(公告)日：2013-01-01

    申请号：US12996196

    申请日：2009-06-05

    申请人： Wuyuan Lu ,  Davide Zella ,  Min Liu ,  Changqing Li

    发明人： Wuyuan Lu ,  Davide Zella ,  Min Liu ,  Changqing Li

    IPC分类号： C12N5/00 ,  C12N15/00 ,  C12P21/06 ,  C07H21/04 ,  A61K38/00 ,  A61K38/04

    CPC分类号： C07K14/43522

    摘要： The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides as well as methods of treating abnormal conditions, such as malignant tumors, with the methods comprising administering the pharmaceutical compositions of the present invention to a subject in need of treatment thereof.

    摘要翻译： 本发明涉及活化p53的新型多肽，以及编码这些p53活化肽的多核苷酸。 本发明还涉及包含p53激活剂肽的药物组合物以及治疗异常病症如恶性肿瘤的方法，包括将本发明的药物组合物施用于需要治疗的受试者。

    Medical catheter assembly including multi-piece connector
    10.
    发明申请
    Medical catheter assembly including multi-piece connector 失效
    医用导管组件包括多片连接器

    公开(公告)号：US20090182272A1

    公开(公告)日：2009-07-16

    申请号：US12383354

    申请日：2009-03-23

    申请人： Changqing Li ,  Gray Wood ,  Herbert Alan Sundheimer ,  Laddvanh Bouphvichith ,  Patrice A. Weststrate ,  Laurence D. Brenner

    发明人： Changqing Li ,  Gray Wood ,  Herbert Alan Sundheimer ,  Laddvanh Bouphvichith ,  Patrice A. Weststrate ,  Laurence D. Brenner

    IPC分类号： A61M25/16 ,  A61M29/00

    CPC分类号： A61J15/0026 ,  A61J15/0019 ,  A61J15/0034 ,  A61M25/0014 ,  A61M39/0247 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/12 ,  A61M2039/1027 ,  A61M2039/1033 ,  A61M2039/1077 ,  F16L33/225

    摘要： A medical catheter assembly including a multi-piece connector. In one embodiment, the medical catheter assembly is a PEG implanting assembly comprising a tubular dilator and a silicone feeding tube having an internal bolster at its rear end. The assembly also comprises a multi-piece connector comprising an inner ring, a fitting and an outer ring. The inner ring has an outer diameter greater than the inner diameter of the feeding tube and is coaxially disposed within the feeding tube by a friction-fit. The fitting comprises a front portion, an intermediate portion and a rear portion, the intermediate portion including a shoulder having an outer diameter greater than the inner diameter of the feeding tube. The front portion of the fitting is inserted through the rear end of the dilator and is secured to the dilator by a plurality of barbs. The shoulder and the rear portion of the fitting are inserted into the feeding tube through its rear end, with the rear portion of the fitting being inserted into the inner ring and secured thereto by mating threads. The outer ring is inserted over the feeding tube and is positioned between the shoulder and the inner ring, the outer ring being sized to securely retain the feeding tube between the outer ring and the inner ring and between the outer ring and the shoulder.

    摘要翻译： 一种医疗导管组件，包括多片连接器。 在一个实施例中，医疗导管组件是PEG植入组件，其包括管状扩张器和在其后端具有内部枕垫的硅胶进料管。 组件还包括多片连接器，其包括内环，配件和外环。 内圈的外径大于进料管的内径，并通过摩擦配合同轴地设置在进料管内。 该配件包括前部，中间部分和后部，中间部分包括具有大于供给管内径的外径的肩部。 配件的前部插入穿过扩张器的后端，并通过多个倒钩固定到扩张器。 配件的肩部和后部通过其后端插入进料管中，配件的后部插入内圈并通过配合螺纹固定在其上。 外环被插入进料管上并且位于肩部和内圈之间，外圈的尺寸设计成将进料管牢固地保持在外圈和内圈之间以及在外圈和肩部之间。