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公开(公告)号：US20160333105A1
公开(公告)日：2016-11-17
申请号：US15165131
申请日：2016-05-26
Applicant: UCB PHARMA S.A.
Inventor： Ralph Adams , Emma Dave , David Paul Humphreys
Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.
Abstract translation: 本发明提供了一种多价抗体或其重/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 其中至少一个选自CH 2，CH 3及其组合的结构域，条件是重链含有不超过一个CH1结构域并且仅含有两个可变结构域，以及包含位于两个可变结构域之间的恒定区片段的轻链， 不是同源对，其中所述重链和轻链对齐以提供由第一同源对可变结构域形成的第一结合位点和由第二同源对可变结构域形成的第二结合位点。
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2.发明授权Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind CD154 and uses thereof 有权结合蛋白质，包括特异性结合CD154的抗体，抗体衍生物和抗体片段及其用途公开(公告)号：US09321840B2
公开(公告)日：2016-04-26
申请号：US14309118
申请日：2014-06-19
Applicant: UCB PHARMA S.A. , BIOGEN IDEC MA INC.
Inventor： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
CPC classification number: C07K16/2875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/734 , C07K2317/76 , C07K2317/92
Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
Abstract translation: 本发明提供特异性结合CD154（CD40L）蛋白的结合蛋白，包括抗体，抗体衍生物和抗体片段。 本发明还提供了嵌合，人源化或完全人抗体，抗体衍生物或抗体片段，其特异性结合包含根据SEQ ID NO：1的可变重链序列的人源化Fab片段的表位，并包含可变轻链序列 根据SEQ ID NO：2特异性结合。 本发明的CD154结合蛋白可以引起相对于第二抗-CD154抗体降低的效应子功能。 本发明的CD154结合蛋白可用于诊断和治疗方法，例如治疗和预防包括由CD154-CD40相互作用介导的不期望的免疫应答的疾病。
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公开(公告)号：US20150147331A1
公开(公告)日：2015-05-28
申请号：US14489837
申请日：2014-09-18
Applicant: UCB PHARMA S.A.
Inventor： Ralph Adams , Andrew George Popplewell , Stephen Edward Rapecki , Simon Peter Tickle
IPC: C07K16/24
CPC classification number: C07K16/244 , A61K47/60 , A61K2039/505 , C07K16/464 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
Abstract translation: 本发明涉及对IL-17的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：US20200048372A1
公开(公告)日：2020-02-13
申请号：US16508967
申请日：2019-07-11
Applicant: UCB PHARMA S.A.
Inventor： Ralph Adams , Laura Hancock , Sam Philip Heywood
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab′ fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
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公开(公告)号：US20140024077A1
公开(公告)日：2014-01-23
申请号：US13928458
申请日：2013-06-27
Applicant: UCB Pharma S.A.
Inventor： Richard Evan Gelinas , Mitra Choudhury Singhal , Yi Zhang , Andrew George Popplewell , Ralph Adams
IPC: C07K16/24
CPC classification number: A61K39/3955 , A61K2039/505 , C07K16/248 , C07K2316/96 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08617847B2
公开(公告)日：2013-12-31
申请号：US13632702
申请日：2012-10-01
Applicant: UCB Pharma S.A.
Inventor： Ralph Adams , Andrew George Popplewell , Stephen Edward Rapecki
IPC: C12P21/08
CPC classification number: C07K16/468 , A61K39/3955 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。
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公开(公告)号：US20130243772A1
公开(公告)日：2013-09-19
申请号：US13672077
申请日：2012-11-08
Applicant: UCB PHARMA S.A.
Inventor： Ralph Adams , Pallavi Bhatta , Sam Phillip Heywood , David Paul Humphreys
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：US20130102030A1
公开(公告)日：2013-04-25
申请号：US13632702
申请日：2012-10-01
Applicant: UCB PHARMA S.A.
Inventor： Ralph Adams , Andrew George Popplewell , Stephen Edward Rapecki
IPC: C07K16/46
CPC classification number: C07K16/468 , A61K39/3955 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。
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公开(公告)号：US12091450B2
公开(公告)日：2024-09-17
申请号：US16717671
申请日：2019-12-17
Applicant: UCB PHARMA S.A.
Inventor： David Paul Humphreys , Ralph Adams , James Heads , Shirley Jane Peters
IPC: C07K16/00 , A61K39/395 , C07K16/24 , C12P21/08
CPC classification number: C07K16/24 , A61K39/39591 , C07K16/00 , C07K2317/40 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/94
Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
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10.发明申请公开(公告)号：US20150322147A1
公开(公告)日：2015-11-12
申请号：US14706234
申请日：2015-05-07
Applicant: UCB Pharma S.A.
Inventor： Ralph Adams , Andrew George Popplewell , Stephen Edward Rapecki
IPC: C07K16/24 , A61K39/395
CPC classification number: C07K16/468 , A61K39/3955 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。
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