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62 条记录 (耗时 0.019 秒)

    Preparation of pyrroles from dialkoxytetrahydrofurans
    1.
    发明授权
    Preparation of pyrroles from dialkoxytetrahydrofurans 失效
    从二烷氧基四氢呋喃制备吡咯

    公开(公告)号：US4906758A

    公开(公告)日：1990-03-06

    申请号：US231259

    申请日：1988-08-12

    申请人： Wolfgang Hoelderich ,  Michael Hesse ,  Hardo Siegel

    发明人： Wolfgang Hoelderich ,  Michael Hesse ,  Hardo Siegel

    IPC分类号： C07D207/32 ,  C07D207/323 ,  C07B43/04

    CPC分类号： C07D207/323 ,  Y02P20/582

    摘要： Pyrroles of the formula I ##STR1## are prepared by a process in which a dialkoxytetrahydrofuran of the formula II ##STR2## where R.sup.2 to R.sup.5 in the formulae (I) and (II) are identical or different and are each hydrogen, a straight-chain or branched alkyl or alkenyl radical of not more than 12 carbon atoms, a cycloalkyl or cycloalkenyl radical of 5 to 8 carbon atoms, an aryl, alkylaryl or aralkyl radical of 6 to 16 carbon atoms, and two non-adjacent radicals R.sup.6 to R.sup.9 are alkoxy and the other two radicals R.sup.6 to R.sup.9 are hydrogen, is reacted with ammonia or a primary amine H.sub.2 NR.sup.1, where R.sup.1 in formula (I) is hydrogen, alkyl, aryl, alkylaryl, aralkyl or cycloalkyl, in the presence of an acidic, solid, heterogeneous catalyst. Zeolites, for example those of the pentasil type or faujasite type, or phosphates, acidic oxides, phosphoric acid or boric acid on a carrier can be used as the solid heterogeneous catalysts.

    摘要翻译： 式I（I）的吡咯可以通过其中式II（II）的二烷氧基四氢呋喃与式（I）和（II）中的R 2至R 5相同或不同的方法制备， 每个氢，不超过12个碳原子的直链或支链烷基或烯基，5-8个碳原子的环烷基或环烯基，6-16个碳原子的芳基，烷芳基或芳烷基， 相邻的基团R6至R9为烷氧基，另外两个基团R6至R9为氢，与氨或伯胺H 2 N R 1反应，其中式（I）中的R 1为氢，烷基，芳基，烷基芳基，芳烷基或环烷基， 酸性，固体，非均相催化剂的存在。 作为固体多相催化剂，可以使用沸石，例如pentasil类型或八面沸石型沸石，或载体上的磷酸盐，酸性氧化物，磷酸或硼酸。

    Preparation of unsaturated monoesters
    2.
    发明授权
    Preparation of unsaturated monoesters 失效
    制备不饱和单酯

    公开(公告)号：US5196571A

    公开(公告)日：1993-03-23

    申请号：US815649

    申请日：1991-12-30

    申请人： Wolfgang Hoelderich ,  Hardo Siegel

    发明人： Wolfgang Hoelderich ,  Hardo Siegel

    IPC分类号： C07C67/02

    CPC分类号： C07C67/02 ,  C07C67/297 ,  Y02P20/582

    摘要： Unsaturated monoesters of the formula (I) ##STR1## are prepared from diesters of the formula (II) ##STR2## where the radicals R.sup.1 to R.sup.5 in the formulae (I) and (II) are identical to each other and each is hydrogen, straight-chain or branched alkyl or alkenyl of from 1 to 10 carbon atoms, cycloalkyl or cycloalkylene of from 5 to 8 carbon atoms, aryl, alkylaryl or aralkyl, by reaction in the presence of a zeolite and/or phosphate as a catalyst with the elimination of a carboxylic acid R.sup.6 COOH where R.sup.6 is hydrogen or alkyl of from 1 to 6 carbon atoms, n being an integer from 1 to 10.

    摘要翻译： 式（I）的不饱和一元素由式（Ⅱ）的二酯制备，其中式（I）和（II）中的基团R 1至R 5彼此相同，各自为氢， 具有1至10个碳原子的直链或支链烷基或烯基，5至8个碳原子的环烷基或亚环烷基，芳基，烷基芳基或芳烷基，通过在沸石和/或磷酸盐作为催化剂存在下与 消除羧基R6COOH，其中R6是氢或1至6个碳原子的烷基，n是1到10的整数。

    Preparation of 1,4-alkylenediamines
    4.
    发明授权
    Preparation of 1,4-alkylenediamines 失效
    1,4-亚烷基二胺的制备

    公开(公告)号：US5254738A

    公开(公告)日：1993-10-19

    申请号：US657632

    申请日：1991-02-19

    申请人： Ulrich Koehler ,  Hardo Siegel ,  Matthias Irgang

    发明人： Ulrich Koehler ,  Hardo Siegel ,  Matthias Irgang

    IPC分类号： B01J23/889 ,  B01J27/185 ,  C07B61/00 ,  C07C209/48 ,  C07C211/09 ,  C07C211/27

    CPC分类号： C07C209/48

    摘要： A process for the preparation of a 1,4-alkylenediamine of the general formula I ##STR1## in which the substituents R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1 -C.sub.10 -alkyl, phenyl or benzyl, by reacting a succinic dinitrile of the general formula II ##STR2## in which R.sup.1 and R.sup.2 have the meanings stated, with hydrogen at a temperature of from 30.degree. to 250.degree. C. and a pressure of from 50 to 350 bar in contact with a hydrogenation catalyst, wherein the hydrogenation catalyst used contains cobalt oxide and one or more oxides of the elements iron, nickel, manganese, chromium, molybdenum, tungsten, and phosphorus and one or more oxides of elements in the alkali metal group, alkaline earth metal group, and rare earth group of the Periodic Table, and of scandium, and/or of yttrium.

    摘要翻译： 制备通式I（I）的1,4-亚烷基二胺的方法，其中取代基R 1和R 2独立地为氢，C 1 -C 10 - 烷基，苯基或苄基，通过使琥珀酸二腈与 其中R1和R2具有所述含义的通式II（II），氢气在30℃至250℃的温度和50至350巴的压力下与氢化催化剂接触， 其中使用的氢化催化剂包含氧化钴和一种或多种元素铁，镍，锰，铬，钼，钨和磷的氧化物和一种或多种碱金属组元素，碱土金属组和稀有元素中的元素氧化物 周期表地球组，钪和/或钇。

    Sterically hindered 4-amino-piperidine with a low dimer content, its production and use
    8.
    发明授权
    Sterically hindered 4-amino-piperidine with a low dimer content, its production and use 失效
    四聚体含量低的4-氨基哌啶，其生产和使用

    公开(公告)号：US6013803A

    公开(公告)日：2000-01-11

    申请号：US180580

    申请日：1998-11-12

    申请人： Manfred Julius ,  Harald Rust ,  Alfred Krause ,  Hardo Siegel ,  Wolfgang Siegel ,  Tom Witzel

    发明人： Manfred Julius ,  Harald Rust ,  Alfred Krause ,  Hardo Siegel ,  Wolfgang Siegel ,  Tom Witzel

    IPC分类号： C07B63/04 ,  C07D211/58 ,  C07D211/72 ,  C07D221/20 ,  C08K5/3435

    CPC分类号： C08K5/3435 ,  C07D211/58

    摘要： The invention relates to a process for reducing the dimerization of piperidines of the formula I ##STR1## where R.sup.1 to R.sup.4 are C.sub.1 - to C.sub.6 -alkyl, R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together are a CH.sub.2 chain having 2 to 5 carbon atoms, which comprises adding to the piperidine from 0.001 to 0.2% by weight of a reducing agent of the formula MXH.sub.4-m Y.sub.m, where M is an alkali metal, NR.sub.4, where R are identical or different C.sub.1 -C.sub.4 -alkyl groups, or an equivalent of an alkaline earth metal or an equivalent of zinc, X is boron or aluminum, Y is H or CN and m is 0 or 1. The invention also relates to a mixture of piperidines of the formula I, from 0.001 to 0.2% by weight of a reducing agent and from 1 to 1000 ppm of dimers of the piperidines of the formula I, and to the preparation of hindered amine light stabilizers therefrom.

    摘要翻译： PCT No.PCT / EP97 / 02763 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月28日PCT公布。 出版物WO97 / 46528 日期1997年12月11日本发明涉及一种降低式Ⅰ哌啶的二聚的方法，其中R 1至R 4为C 1至C 6烷基，R 1和R 2和/或R 3和R 4一起为具有2至 5个碳原子，其包括向所述哌啶中添加0.001至0.2重量％的式MXH4-mYm的还原剂，其中M是碱金属，NR4，其中R是相同或不同的C 1 -C 4 - 烷基， 或当量的碱土金属或当量的锌，X为硼或铝，Y为H或CN，m为0或1.本发明还涉及式I的哌啶的混合物，为0.001至0.2 重量％的还原剂和1至1000ppm式I的哌啶的二聚体，以及由其制备受阻胺光稳定剂。

    Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds
    10.
    发明授权
    Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds 失效
    取代的2-羟基丙酸的氨基酚衍生物和含有这些化合物的治疗剂

    公开(公告)号：US5118685A

    公开(公告)日：1992-06-02

    申请号：US677307

    申请日：1984-12-03

    申请人： Albrecht Franke ,  Wolfgang Spiegler ,  Hardo Siegel ,  Claus D. Mueller ,  Gerda von Philipsborn ,  Dieter Lenke ,  Josef Gries

    发明人： Albrecht Franke ,  Wolfgang Spiegler ,  Hardo Siegel ,  Claus D. Mueller ,  Gerda von Philipsborn ,  Dieter Lenke ,  Josef Gries

    IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

    CPC分类号： C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

    摘要： Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, and antiarrhythmic agents containing these compounds.

    摘要翻译： 具有下式的氨基丙醇衍生物：其中R 1和R 2相同或不同，并且各自为氢，烷基，环烷基，烯基，炔基或羟烷基，各自不超过6个碳原子，烷氧基烷基，烷硫基烷基或二烷基氨基烷基，各自为 不超过9个碳原子，或苯基烷基或苯氧基烷基，其中烷基不超过6个碳原子，苯基是未取代的或被不多于3个碳原子的烷基或烷氧基取代，或者R1和 R2与连接它们的氮原子一起形成可被一个或两个苯基和/或羟基取代的5元至7元饱和杂环，并且可以含有氧或氮原子作为另外的杂原子 并且这样的另外的氮原子可以被1至3个碳原子的烷基或苯基取代，并且 - ＆C 1 H e是噻吩-2-基，噻吩-3-基，吡啶-2-基，吡啶-2-基， 吡啶-4-基，呋喃-2-基，1-烷基吡咯-2-基，1-烷基 1-吡咯-3-基或1-烷基吡唑-4-基，具有1至3个碳原子的烷基，以及它们与酸的生理上可耐受的加成盐，和含有这些化合物的抗心律不齐剂。