摘要:
An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
摘要翻译:本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式(I)表示或其药学上可接受的盐或溶剂化物:其中X = CH或N; Z = O或S; L = 0或S; M = CR10R11,其中R10和R11 = H,烷基或烷氧基,NR12,其中R12 = H或烷基; R1,R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H,卤素,烷氧基等; 并且R 9 =任选被-T-R 15或-NR 16 R 17取代的烷基,其中T = O,S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环,或-NR 18 R 19,其中R 18和R 19 = H,任选取代的烷基,或任选取代的碳环或杂环,或任选取代的碳环或杂环。
摘要:
An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
摘要翻译:本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式(I)表示或其药学上可接受的盐或溶剂化物:其中X = CH或N; Z = O或S; L = O或S; M = CR10R11,其中R10和R11 = H,烷基或烷氧基,NR12,其中R12 = H或烷基; R1,R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H,卤素,烷氧基等; 并且R 9 =任选被-R 14,-T-R 15或-NR 16 R 17取代的烷基,其中T = O,S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环,或-NR 18 R 19,其中R 18和R 19 = H,任选取代的烷基,或任选取代的碳环或杂环,或任选取代的碳环或杂环。
摘要:
An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X═CH or N; Z═O or S; L=O or S; M=CR10R11, wherein R10 and R11═H, alkyl, or alkoxy, NR12 wherein R12═H or alkyl; R1, R2, and R3═H or optionally substituted alkoxy; R4═H; R5-8═H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19═H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
摘要翻译:本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式(I)表示或其药学上可接受的盐或溶剂合物:其中X = CH或N; Z = O或S; L = O或S; M = CR10R11,其中R10和R11 = H,烷基或烷氧基,NR12,其中R12 = H或烷基; R1,R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H,卤素,烷氧基等; 并且R 9 =任选被-R 14,-T-R 15或-NR 16 R 17取代的烷基,其中T = O,S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环,或-NR 18 R 19,其中R 18和R 19 = H,任选取代的烷基,或任选取代的碳环或杂环,或任选取代的碳环或杂环。
摘要:
An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
摘要翻译:本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式(I)表示或其药学上可接受的盐或溶剂化物:其中X = CH或N; Z = O或S; L = O或S; 其中R 10和R 11 = H,烷基或烷氧基,NR(R 11) 其中R 12 = H或烷基; R 1,R 2和R 3 = H或任选取代的烷氧基; R 4 = H; R 5〜8 = H,卤素,烷氧基等; 和R 9 =任选被-R 14,-TR 15或-NR 16 R 15取代的烷基, 其中T = O,S或NH; R 14是任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环,或-NR 18 R 19其中R 18, R 00和R 19 = H,任选取代的烷基,或任选取代的碳环或杂环,或任选取代的碳环或杂环。
摘要:
A manufacturing method produces a liquid ejecting head including first and second flow path members having liquid flow paths that communicate with each other. An integrally-molded member is surrounds the second flow path member on the second flow path member side of the first flow path member to join the first and second flow path members together. A holding process defines a space portion for forming the integrally-molded member in a frame section. The frame section is brought into contact with a contact surface of a recessed portion in the face of the second flow path member opposite the first flow path member, with the first and second flow path members contacting each other such that the liquid flow paths communicate with each other. A molding process fills the space portion with resin, thereby molding the integrally-molded member, and joins the first and second flow path members together.
摘要:
There is provided a method of manufacturing a liquid ejecting head which includes a head main body having nozzles ejecting a liquid supplied via a liquid supply passage, a first supply member having a first liquid supply passage forming a part of the liquid supply passage, a second supply member disposed on a downstream side of the first supply member and having a second liquid supply passage communicating with the first liquid supply passage and forming a part of the liquid supply passage, a filter disposed between the first and second supply members so as to cross the liquid supply passage, and an integrally molded member fixing the first and second supply members by a resin in a state where the filter is nipped between the first and second supply members. The method includes: forming a supporting protrusion protruding toward the filter and supporting the filter on an inner wall surface of at least one of the first and second supply members; and forming the integrally molded member in the state where the filter is nipped between the first and second supply members and a pressure difference is caused between the first and second supply members on both sides of the filter so that a pressure is lower on the side of the supporting protrusion.
摘要:
A liquid ejecting head includes: a head body which ejects a liquid supplied from a liquid storing member via a liquid supply path; a first supply member which is provided with a first liquid supply path forming a part of the liquid supply path; a second supply member which is provided with a second liquid supply path communicating with the first liquid supply path and forming a part of the liquid supply path, and which supplies the liquid to the head body; and a filter which is sandwiched between the first and second liquid supply paths, wherein a sandwiching portion including the first and second supply members and sandwiching the filter includes an inclination portion that is inclined to the downstream side so as to face the outside of the liquid supply path. A liquid ejecting apparatus includes the liquid ejecting head.
摘要:
A method of manufacturing a liquid ejecting head is disclosed. The head includes first and second supply members forming parts of a liquid supply passage. The liquid ejecting head includes a filter disposed between the first and second supply members so as to cross the liquid supply passage, and an integrally molded member fixing the first and second supply members by a resin in a state where the filter is nipped between the first and second supply members. The method includes: disposing the filter in one of the first and second supply members; nipping the filter by the first and second supply members in a state where the filter is sucked, adsorbed, and positioned via a suction hole of the first or second supply member; and forming the integrally molded member in the state where the filter is nipped between the first and second supply members.
摘要:
[Object] To provide a liquid container allowing improvement of its dimensional precision. [Solving Means] An ink cartridge 22 as a liquid container includes a case 23 having a case body 30 and a lid case 32, and a moving member 36 attached to a surface of a flexible ink pack 25 housed in the case 23. The moving member 36 assumes different positional attitudes inside the case 23 in accordance with the volume of the ink pack 25 that is gradually reduced as the ink therein is consumed, so as to be detected by a detector provided in a printer when the moving member 36 assumes a positional attitude indicating that the ink pack 25 has become empty of ink. The case body 30, lid case 32, and moving member 36 are molded of a material containing at least polylactic acid to achieve a low mold shrinkage rate.
摘要:
The object of the invention is to provide a video switchover detection circuit that reduces the circuit scale and allows high-accuracy detection with a smaller-scale configuration.According to the invention, the video switchover detection circuit comprises a PLL circuit composed of a phase comparator, an LPF, a VCO, and a frequency divider. In the phase comparator, the phase of an external HD as an input signal obtained by shaping the pulse of a horizontal synchronization signal is compared with the phase of an internal HD as a reference signal obtained by dividing the frequency of the output pulse of the VCO in the PLL circuit. In case the phases of the signals differ from each other, an error signal is output from the phase comparator. A first counter counts the period in which the error signal is active, or the time when the phase difference persists. A horizontal synchronization decision section determines the lock state of the horizontal synchronization signal depending on the length of the phase difference duration and in case out of synchronization is detected, a video switchover detection signal is output from an output circuit.