公开(公告)号：US20110105747A1

公开(公告)日：2011-05-05

申请号：US12987610

申请日：2011-01-10

申请人： Yasunari FUJIWARA ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Niwa ,  Kazuhide Nakamura

发明人： Yasunari FUJIWARA ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Niwa ,  Kazuhide Nakamura

IPC分类号： C07D401/12 ,  C07D215/233 ,  C07D413/12 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂化物：其中X = CH或N; Z = O或S; L = 0或S; M = CR10R11，其中R10和R11 = H，烷基或烷氧基，NR12，其中R12 = H或烷基; R1，R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H，卤素，烷氧基等; 并且R 9 =任选被-T-R 15或-NR 16 R 17取代的烷基，其中T = O，S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19，其中R 18和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US20080312221A1

公开(公告)日：2008-12-18

申请号：US12175361

申请日：2008-07-17

申请人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

发明人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

IPC分类号： A61K31/47 ,  C07D215/233 ,  C07D413/12 ,  A61K31/541 ,  A61P35/00 ,  A61K31/5377 ,  C07D417/12

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂化物：其中X = CH或N; Z = O或S; L = O或S; M = CR10R11，其中R10和R11 = H，烷基或烷氧基，NR12，其中R12 = H或烷基; R1，R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H，卤素，烷氧基等; 并且R 9 =任选被-R 14，-T-R 15或-NR 16 R 17取代的烷基，其中T = O，S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19，其中R 18和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US08324245B2

公开(公告)日：2012-12-04

申请号：US12987610

申请日：2011-01-10

申请人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

发明人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X═CH or N; Z═O or S; L=O or S; M=CR10R11, wherein R10 and R11═H, alkyl, or alkoxy, NR12 wherein R12═H or alkyl; R1, R2, and R3═H or optionally substituted alkoxy; R4═H; R5-8═H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19═H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂合物：其中X = CH或N; Z = O或S; L = O或S; M = CR10R11，其中R10和R11 = H，烷基或烷氧基，NR12，其中R12 = H或烷基; R1，R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H，卤素，烷氧基等; 并且R 9 =任选被-R 14，-T-R 15或-NR 16 R 17取代的烷基，其中T = O，S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19，其中R 18和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US07425564B2

公开(公告)日：2008-09-16

申请号：US10480632

申请日：2002-06-21

申请人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

发明人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

IPC分类号： A61K31/47

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂化物：其中X = CH或N; Z = O或S; L = O或S; 其中R 10和R 11 = H，烷基或烷氧基，NR（R 11） 其中R 12 = H或烷基; R 1，R 2和R 3 = H或任选取代的烷氧基; R 4 = H; R 5〜8 = H，卤素，烷氧基等; 和R 9 =任选被-R 14，-TR 15或-NR 16 R 15取代的烷基， 其中T = O，S或NH; R 14是任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19其中R 18， R 00和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US08500255B2

公开(公告)日：2013-08-06

申请号：US12712010

申请日：2010-02-24

申请人： Hiroshige Owaki ,  Hiroyuki Kobayashi ,  Kazuhide Nakamura

发明人： Hiroshige Owaki ,  Hiroyuki Kobayashi ,  Kazuhide Nakamura

IPC分类号： B41J2/175

CPC分类号： B41J2/16 ,  B41J2/1637

摘要： A manufacturing method produces a liquid ejecting head including first and second flow path members having liquid flow paths that communicate with each other. An integrally-molded member is surrounds the second flow path member on the second flow path member side of the first flow path member to join the first and second flow path members together. A holding process defines a space portion for forming the integrally-molded member in a frame section. The frame section is brought into contact with a contact surface of a recessed portion in the face of the second flow path member opposite the first flow path member, with the first and second flow path members contacting each other such that the liquid flow paths communicate with each other. A molding process fills the space portion with resin, thereby molding the integrally-molded member, and joins the first and second flow path members together.

摘要翻译： 制造方法产生包括具有彼此连通的液体流路的第一和第二流路部件的液体喷射头。 一体模制构件围绕第一流路构件的第二流动通道构件侧上的第二流动通道构件，以将第一和第二流路构件连接在一起。 保持工艺限定了用于在框架部分中形成整体模制构件的空间部分。 框架部分与第二流路部件的与第一流路部件相对的面的凹部的接触表面接触，第一和第二流路部件彼此接触，使得液体流动路径与 彼此。 模制工艺用树脂填充空间部分，从而模制整体模制的构件，并将第一和第二流路构件连接在一起。

公开(公告)号：US20110031641A1

公开(公告)日：2011-02-10

申请号：US12853171

申请日：2010-08-09

申请人： Hiroyuki Kobayashi ,  Katsuhiro Okubo ,  Kazuhide Nakamura ,  Nobuyoshi Uji

发明人： Hiroyuki Kobayashi ,  Katsuhiro Okubo ,  Kazuhide Nakamura ,  Nobuyoshi Uji

IPC分类号： B29C45/14

CPC分类号： B29C45/14467 ,  B29C45/14836 ,  B29C45/34 ,  B29L2031/14 ,  B29L2031/767

摘要： There is provided a method of manufacturing a liquid ejecting head which includes a head main body having nozzles ejecting a liquid supplied via a liquid supply passage, a first supply member having a first liquid supply passage forming a part of the liquid supply passage, a second supply member disposed on a downstream side of the first supply member and having a second liquid supply passage communicating with the first liquid supply passage and forming a part of the liquid supply passage, a filter disposed between the first and second supply members so as to cross the liquid supply passage, and an integrally molded member fixing the first and second supply members by a resin in a state where the filter is nipped between the first and second supply members. The method includes: forming a supporting protrusion protruding toward the filter and supporting the filter on an inner wall surface of at least one of the first and second supply members; and forming the integrally molded member in the state where the filter is nipped between the first and second supply members and a pressure difference is caused between the first and second supply members on both sides of the filter so that a pressure is lower on the side of the supporting protrusion.

摘要翻译： 提供了一种制造液体喷射头的方法，该喷射头包括：头主体，其具有喷射经由液体供应通道供应的液体的喷嘴;第一供应构件，具有形成液体供应​​通道的一部分的第一液体供应通道， 供给部件配置在第一供给部件的下游侧，具有与第一供液通路连通并形成液体供给通路的一部分的第二液体供给通路，配置在第一供给部件和第二供给部件之间， 液体供应通道，以及在过滤器被夹持在第一和第二供应构件之间的状态下用树脂固定第一和第二供应构件的整体模制件。 该方法包括：形成朝向过滤器突出的支撑突起，并且将过滤器支撑在第一和第二供应构件中的至少一个的内壁表面上; 并且在过滤器被夹持在第一和第二供应构件之间的状态下形成整体模制构件，并且在过滤器的两侧上的第一和第二供应构件之间产生压力差，使得在过滤器的侧面上的压力较低 支撑突起。

公开(公告)号：US08820905B2

公开(公告)日：2014-09-02

申请号：US13010218

申请日：2011-01-20

申请人： Hiroyuki Kobayashi ,  Munehide Kanaya ,  Katsuhiro Okubo ,  Nobuyoshi Uji ,  Kazuhide Nakamura

发明人： Hiroyuki Kobayashi ,  Munehide Kanaya ,  Katsuhiro Okubo ,  Nobuyoshi Uji ,  Kazuhide Nakamura

IPC分类号： B41J2/175 ,  B41J2/14

CPC分类号： B41J2/14233 ,  B41J2002/14362 ,  B41J2002/14403

摘要： A liquid ejecting head includes: a head body which ejects a liquid supplied from a liquid storing member via a liquid supply path; a first supply member which is provided with a first liquid supply path forming a part of the liquid supply path; a second supply member which is provided with a second liquid supply path communicating with the first liquid supply path and forming a part of the liquid supply path, and which supplies the liquid to the head body; and a filter which is sandwiched between the first and second liquid supply paths, wherein a sandwiching portion including the first and second supply members and sandwiching the filter includes an inclination portion that is inclined to the downstream side so as to face the outside of the liquid supply path. A liquid ejecting apparatus includes the liquid ejecting head.

摘要翻译： 液体喷射头包括：头体，其经由液体供给路径喷射从液体存储部件供给的液体; 第一供给部件，设置有形成液体供给路径的一部分的第一液体供给路径; 第二供应构件，其具有与第一液体供应路径连通并形成液体供应​​路径的一部分的第二液体供应路径，并将液体供应到头部主体; 以及夹在所述第一和第二液体供给路径之间的过滤器，其中包括所述第一和第二供应构件并夹持所述过滤器的夹持部分包括倾斜部分，所述倾斜部分向下游侧倾斜以面对所述液体的外部 供应路径。 液体喷射装置包括液体喷射头。

公开(公告)号：US08171635B2

公开(公告)日：2012-05-08

申请号：US12853163

申请日：2010-08-09

申请人： Hiroyuki Kobayashi ,  Katsuhiro Okubo ,  Kazuhide Nakamura ,  Nobuyoshi Uji

发明人： Hiroyuki Kobayashi ,  Katsuhiro Okubo ,  Kazuhide Nakamura ,  Nobuyoshi Uji

IPC分类号： B21D53/76 ,  B23P17/00 ,  B41J2/015

CPC分类号： B41J2/175 ,  B41J2/17563 ,  Y10T29/49401

摘要： A method of manufacturing a liquid ejecting head is disclosed. The head includes first and second supply members forming parts of a liquid supply passage. The liquid ejecting head includes a filter disposed between the first and second supply members so as to cross the liquid supply passage, and an integrally molded member fixing the first and second supply members by a resin in a state where the filter is nipped between the first and second supply members. The method includes: disposing the filter in one of the first and second supply members; nipping the filter by the first and second supply members in a state where the filter is sucked, adsorbed, and positioned via a suction hole of the first or second supply member; and forming the integrally molded member in the state where the filter is nipped between the first and second supply members.

摘要翻译： 公开了一种液体喷射头的制造方法。 头包括形成液体供应​​通道的部分的第一和第二供应构件。 液体喷射头包括设置在第一和第二供应构件之间以过渡液体供应通道的过滤器，以及在过滤器被夹持在第一和第二供应构件之间的状态下通过树脂固定第一和第二供应构件的整体模制构件 和第二供应成员。 该方法包括：将过滤器设置在第一和第二供应构件之一中; 在过滤器被吸入，吸附和经由第一或第二供应构件的抽吸孔定位的状态下，通过第一和第二供应构件夹持过滤器; 并且在过滤器被夹持在第一和第二供应构件之间的状态下形成一体模制构件。

公开(公告)号：US20080036828A1

公开(公告)日：2008-02-14

申请号：US11735090

申请日：2007-04-13

申请人： Hisashi Koike ,  Kazuhide Kubota ,  Kazuyo Haraguchi ,  Mitsuto Yanagisawa ,  Kazuhide Nakamura ,  Kentaro Miyazaki ,  Yuki Ono

发明人： Hisashi Koike ,  Kazuhide Kubota ,  Kazuyo Haraguchi ,  Mitsuto Yanagisawa ,  Kazuhide Nakamura ,  Kentaro Miyazaki ,  Yuki Ono

IPC分类号： B41J2/175

CPC分类号： B41J2/17509 ,  B41J2/17513 ,  B41J2/17566

摘要： [Object] To provide a liquid container allowing improvement of its dimensional precision. [Solving Means] An ink cartridge 22 as a liquid container includes a case 23 having a case body 30 and a lid case 32, and a moving member 36 attached to a surface of a flexible ink pack 25 housed in the case 23. The moving member 36 assumes different positional attitudes inside the case 23 in accordance with the volume of the ink pack 25 that is gradually reduced as the ink therein is consumed, so as to be detected by a detector provided in a printer when the moving member 36 assumes a positional attitude indicating that the ink pack 25 has become empty of ink. The case body 30, lid case 32, and moving member 36 are molded of a material containing at least polylactic acid to achieve a low mold shrinkage rate.

摘要翻译： 提供一种能够提高其尺寸精度的液体容器。 [解决方案]作为液体容器的墨盒22包括具有壳体30和盖壳体32的壳体23和安装在容纳在壳体23中的柔性墨盒25的表面上的移动部件36。 移动构件36根据随着其中的墨水被消耗而逐渐减小的墨盒25的体积而在壳体23内呈现不同的位置态度，以便当移动构件36被设置在打印机中时由检测器检测到 呈现指示墨水包25已经变空的位置姿态。 壳体30，盖壳体32和移动部件36由至少含有聚乳酸的材料模制，以实现低的模具收缩率。

公开(公告)号：US06847409B2

公开(公告)日：2005-01-25

申请号：US10048506

申请日：2001-05-30

申请人： Takehiko Sakai ,  Daijiro Kawai ,  Kazuhide Nakamura

发明人： Takehiko Sakai ,  Daijiro Kawai ,  Kazuhide Nakamura

IPC分类号： H04N5/268 ,  G06F3/14 ,  G09G5/12 ,  H03L7/095 ,  H04N7/18

CPC分类号： G06F3/14 ,  G09G5/12 ,  G09G2320/103 ,  G09G2320/106 ,  H03L7/095

摘要： The object of the invention is to provide a video switchover detection circuit that reduces the circuit scale and allows high-accuracy detection with a smaller-scale configuration.According to the invention, the video switchover detection circuit comprises a PLL circuit composed of a phase comparator, an LPF, a VCO, and a frequency divider. In the phase comparator, the phase of an external HD as an input signal obtained by shaping the pulse of a horizontal synchronization signal is compared with the phase of an internal HD as a reference signal obtained by dividing the frequency of the output pulse of the VCO in the PLL circuit. In case the phases of the signals differ from each other, an error signal is output from the phase comparator. A first counter counts the period in which the error signal is active, or the time when the phase difference persists. A horizontal synchronization decision section determines the lock state of the horizontal synchronization signal depending on the length of the phase difference duration and in case out of synchronization is detected, a video switchover detection signal is output from an output circuit.

摘要翻译： 本发明的目的是提供一种视频切换检测电路，其减小电路规模，并允许以较小规模配置的高精度检测。根据本发明，视频切换检测电路包括由相位比较器 ，LPF，VCO和分频器。 在相位比较器中，将通过对水平同步信号的脉冲进行整形而获得的输入信号的外部HD的相位与内部HD的相位进行比较，作为通过将VCO的输出脉冲的频率除以 在PLL电路中。 在信号的相位彼此不同的情况下，从相位比较器输出误差信号。 第一个计数器对错误信号有效的时间段或相位差持续的时间进行计数。 水平同步决定部根据相位差持续时间的长短来决定水平同步信号的锁定状态，在检测到不同步的情况下，从输出电路输出视频切换检测信号。