公开(公告)号：US20190203270A1

公开(公告)日：2019-07-04

申请号：US16319499

申请日：2016-07-24

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Ido AMIT ,  David LARA-ASTIASO ,  Meital GURY

IPC: C12Q1/6811 ,  C12Q1/6818 ,  C12Q1/6876

CPC classification number: C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6818 ,  C12Q1/6876 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N33/6875 ,  C12Q2522/101 ,  C12Q2563/185

Abstract: Methods of analyzing DNA molecules in a cell sample are provided. The DNA molecules have DNA binding moiety signatures which are defined by at least two non-identical DNA binding moieties. Kits for analyzing the DNA are also provided.

公开(公告)号：US20190194653A1

公开(公告)日：2019-06-27

申请号：US16330774

申请日：2017-09-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Diego JAITIN ,  David LARA-ASTIASO ,  Assaf WEINER ,  Ido YOFE

IPC: C12N15/11 ,  C12N15/10 ,  C12N9/22 ,  C12Q1/6883

CPC classification number: C12N15/11 ,  C12N9/22 ,  C12N15/102 ,  C12N15/1093 ,  C12N15/63 ,  C12N2310/20 ,  C12N2800/80 ,  C12Q1/6883

Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.